A Mixed-Method Investigation into Therapeutic Yoga as an Adjunctive Treatment for People Recovering from Substance Use Disorders

© 2020, The Author(s). Mind Body Connect (MBC) is a charity which uses therapeutic yoga as a vehicle of change for marginalized populations. Alongside MBC, Sheffield Hallam University’s SHU Strength researchers carried out this study aiming to: (1) Gauge the impact of therapeutic yoga classes upon the mood state of people with a Substance Use Disorder (SUD) and (2) Explore the perceived benefits of therapeutic yoga class participation. An adapted shortened Profile of Mood States (POMS) was completed before and after each yoga class. A comparison of means with paired sample T-Test and Cohen’s D was then carried out. Participants who attended 6+ classes were interviewed. Findings were then converged. Before and after measurements of anger, sadness, tiredness, worry, confusion, energy and relaxation were taken, Classes were held at SHU for service users from a Phoenix Future’s (PF) rehabilitation centre. A single yoga class significantly relaxed participants and reduced negative mood states. Interview data covered a range of perceived benefits including the use of yogic down-regulation techniques as daily coping strategies. The MBC yoga programme appears beneficial as an adjunctive therapy for PF residents. Future SHU Strength research shall focus on the mid-long-term exercise habits of the recovery community and the impact of the MBC yoga programme upon the early recovery period of detoxification

Does the Human Assisted Reproductive Technology Act 2004 need a review?

The use of assisted reproductive technologies (ART) in New Zealand is governed by the Human Assisted Reproductive Technology Act 2004 (the HART Act), which provides for all procedures currently undertaken by fertility clinics and other centres involved with ART. Although the Act has provided good coverage for the use of ART over the last 16 years, it did not have a revision clause. Here, we explore whether the HART Act should be reviewed, and outline the important considerations that need to be taken into account to ensure that the legislation is up to date with current issues and technologies

Hope: Valuing lives and persons with degenerative conditions — Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is a life-shortening genetic condition involving progressive muscular wasting for which there is no hope of recovery at present. The lives of people with DMD, cherished by their families, are systematically marginalised and undervalued by healthcare bureaucracies while enrolment in clinical trials of new treatments offers possibilities of longer-term biomedical solutions. How is hope preserved under such circumstances and what activities can promote a full and meaningful life for those with DMD Ethnographic research within the DMD community in Aotearoa New Zealand provided a basis for addressing these questions and for understanding different concepts of hope and social suffering, the value of life in DMD and disability studies, and how these are shaped by regimes of governmentality

The Ursinus Weekly, December 19, 1974

SFARC: Alive and very well • The Great Wismer rip-off • Letters to the editor • Two U.C. men named to boards • Basketball begins • Doom or defense? • Grappling goings-on • U.C. tuition increase called modest • An open letter to the student body of Ursinus • Alumni publish • The Ursinus Weaklyhttps://digitalcommons.ursinus.edu/weekly/1028/thumbnail.jp

The Ursinus Weekly, February 13, 1975

Forum will host Jessica Savitch • Lorelei: Midnite at the oasis • Forum review: Morgenthau delivers informative address on complex topic • Classics performed by Temple orchestra • U.C. Chaplain plans Lenten experiences • Purloined pitchers • Music groups active • Phlash! • Interaction between Ursinus past and present • We place ourselves at your disposal • 1975 interview schedule • The old gold remains • New addition to education faculty • The travails of Knorft • Millions for Ursinus • Bears beat Hopkins; Lose to Muhlenberg • Hockey team returns with memories of Great Britain • Spring flicks at Union • Girls\u27 basketball • Distinguished wrestler named coach • Swimmers splash alonghttps://digitalcommons.ursinus.edu/weekly/1029/thumbnail.jp

The Ursinus Weekly, October 17, 1974

N.A.B. named • Freshmen elect officers: Larry Dalaker president • Alumna corner: Color Day • Editorial • Bears are back • Letters to the editor: R.S.W. cut down; Wismer cut down; M.J.H. cut down; And again; Finally, thank you • Salinger myth dissolvedhttps://digitalcommons.ursinus.edu/weekly/1022/thumbnail.jp

136 HIV-1 Nef regulates activity of endoplasmic reticulum chaperone calnexin

HIV-1 Nef promotes viral replication by downmodulating a number of cell surface transmembrane proteins, such as CD4, MHC-I and MHC-II, which are targeted by Nef to various degradation pathways. Nef is also responsible for downregulation of cellular cholesterol transporter ABCA1, and this effect contributes to development of atherosclerosis in HIV infected patients. Surprisingly, in contrast to CD4 and MHC I, to which Nef has to bind to exert downregulation, binding to ABCA1 turned out to be unnecessary for inactivation of ABCA1 by Nef. Here, we identified a novel mechanism by which Nef influences activity of host cell and viral proteins. We show that Nef interacts with an endoplasmic reticulum chaperone calnexin, which is essential for folding and maturation of glycosylated proteins. Nef disrupts calnexin interaction with ABCA1, thus impairing functionality of this protein, but increases affinity and enhances interaction of calnexin with gp160, promoting maturation and functionality of viral Env proteins. Knock-down of calnexin lead to reduced fusion activity of HIV-1 envelope and reduced virion infectivity, as well as to defective cholesterol efflux, which is mediated by ABCA1. However, gp160 and ABCA1 interacted with calnexin differently: while gp160 binding to calnexin was dependent on glycosylation, interaction of ABCA1 with calnexin was glycosylation-independent. Therefore, Nef binds to calnexin and stimulates interaction between calnexin and gp160 at the expense of ABCA1 and probably other ER proteins. These results provide a mechanistic explanation for previously unexplained effect of Nef on functionality of ABCA1, and suggest a mechanism for upregulation of HIV infectivity by Nef through stimulation of Env maturation