A Comprehensive Method of Estimating Electric Fields from Vector Magnetic Field and Doppler Measurements

Photospheric electric fields, estimated from sequences of vector magnetic field and Doppler measurements, can be used to estimate the flux of magnetic energy (the Poynting flux) into the corona and as time-dependent boundary conditions for dynamic models of the coronal magnetic field. We have modified and extended an existing method to estimate photospheric electric fields that combines a poloidal-toroidal (PTD) decomposition of the evolving magnetic field vector with Doppler and horizontal plasma velocities. Our current, more comprehensive method, which we dub the "{\bf P}TD-{\bf D}oppler-{\bf F}LCT {\bf I}deal" (PDFI) technique, can now incorporate Doppler velocities from non-normal viewing angles. It uses the \texttt{FISHPACK} software package to solve several two-dimensional Poisson equations, a faster and more robust approach than our previous implementations. Here, we describe systematic, quantitative tests of the accuracy and robustness of the PDFI technique using synthetic data from anelastic MHD (\texttt{ANMHD}) simulations, which have been used in similar tests in the past. We find that the PDFI method has less than $1$ error in the total Poynting flux and a $10$ error in the helicity flux rate at a normal viewing angle $(\theta=0$) and less than $25$ and $10$ errors respectively at large viewing angles ($\theta<60^\circ$). We compare our results with other inversion methods at zero viewing angle, and find that our method's estimates of the fluxes of magnetic energy and helicity are comparable to or more accurate than other methods. We also discuss the limitations of the PDFI method and its uncertainties.Comment: 56 pages, 10 figures, ApJ (in press

Photospheric Electric Fields and Energy Fluxes in the Eruptive Active Region NOAA 11158

How much electromagnetic energy crosses the photosphere in evolving solar active regions? With the advent of high-cadence vector magnetic field observations, addressing this fundamental question has become tractable. In this paper, we apply the "PTD-Doppler-FLCT-Ideal" (PDFI) electric field inversion technique of Kazachenko et al. (2014) to a 6-day HMI/SDO vector magnetogram and Doppler velocity sequence, to find the electric field and Poynting flux evolution in active region NOAA 11158, which produced an X2.2 flare early on 2011 February 15. We find photospheric electric fields ranging up to $2$ V/cm. The Poynting fluxes range from $[-0.6$ to $2.3]\times10^{10}$ ergs$\cdot$cm$^{-2}$s$^{-1}$, mostly positive, with the largest contribution to the energy budget in the range of $[10^9$-$10^{10}]$ ergs$\cdot$cm$^{-2}$s$^{-1}$. Integrating the instantaneous energy flux over space and time, we find that the total magnetic energy accumulated above the photosphere from the initial emergence to the moment before the X2.2 flare to be $E=10.6\times10^{32}$ ergs, which is partitioned as $2.0$ and $8.6\times10^{32}$ ergs, respectively, between free and potential energies. Those estimates are consistent with estimates from preflare non-linear force-free field (NLFFF) extrapolations and the Minimum Current Corona estimates (MCC), in spite of our very different approach. This study of photospheric electric fields demonstrates the potential of the PDFI approach for estimating Poynting fluxes and opens the door to more quantitative studies of the solar photosphere and more realistic data-driven simulations of coronal magnetic field evolution.Comment: 51 pages, 10 figures, accepted by ApJ on August 11, 201

Epidemiology and potential preventative measures for viral infections in children with malignancy and those undergoing hematopoietic cell transplantation.

In pediatric patients with malignancy and those receiving hematopoietic stem cell transplants, bacterial and fungal infections have been the focus of fever and neutropenia episodes for decades. However, improved diagnostic capabilities have revealed viral pathogens as a significant cause of morbidity and mortality. Because of limited effective antiviral therapies, prevention of viral infections is paramount. Pre-exposure and post-exposure prophylaxis and antiviral suppressive therapeutic approaches are reviewed. Additionally, infection control practices specific to this patient population are discussed. A comprehensive approach utilizing each of these can be effective at reducing the negative impact of viral infections

Racial and Ethnic Differences in Directâ toâ Consumer Genetic Tests Awareness in HINTS 2007: Sociodemographic and Numeracy Correlates

To examine the association of 1) race/ethnicity and 2) numeracy with awareness of DTC genetic tests. Secondary analysis of 6,754 Hispanic, black, and white adult respondents to the National Cancer Institute’s 2007 Health Information National Trends Survey (HINTS). Logistic regression was used to examine sociodemographic predictors of DTC genetic tests awareness including race/ethnicity, income, education, and gender. Next, two numeracy variables were added to the model. After controlling for sociodemographic variables, black respondents were significantly less likely to have heard of DTC genetic tests compared to white respondents (ORâ =â 0.79; CI: 0.65â 0.97). When numeracy variables were added to the model, the effect of black race was no longer significant (ORâ =â 0.84; CI: 0.69â 1.04). Hispanic respondents did not significantly differ from white respondents in awareness of DTC genetic tests. Other significant correlates of DTC genetic tests awareness in the full model included education, income, age, and numeracy variables including degree to which people use medical statistics and numbers to make health decisions, and preference for words or numbers when discussing â the chance of something happening.â Although black respondents were generally less aware of DTC genetic tests than white respondents, this relationship appears to be partially mediated by numeracy.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146912/1/jgc40440.pd

Response to Letter Written by Shelly Cummings, MS, CGC of Myriad Genetics Laboratories, Inc. Regarding the Paper, â Racial and Ethnic Differences in Directâ toâ Consumer Genetic Tests Awareness in HINTS 2007: Sociodemographic and Numeracy Correlates.â J Genet Counsel (2012) 21:440â 447

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/147095/1/jgc40154.pd

G Protein Coupled Receptors in Embryonic Stem Cells: A Role for Gs-Alpha Signaling

Background: Identification of receptor mediated signaling pathways in embryonic stem (ES) cells is needed to facilitate strategies for cell replacement using ES cells. One large receptor family, largely uninvestigated in ES cells, is G protein coupled receptors (GPCRs). An important role for these receptors in embryonic development has been described, but little is known about GPCR expression in ES cells. Methodology/Principal Findings: We have examined the expression profile of 343 different GPCRs in mouse ES cells demonstrating for the first time that a large number of GPCRs are expressed in undifferentiated and differentiating ES cells, and in many cases at high levels. To begin to define a role for GPCR signaling in ES cells, the impact of activating Gs-alpha, one of the major alpha subunits that couples to GPCRs, was investigated. Gs-alpha activation resulted in larger embryoid bodies (EBs), due, in part, to increased cell proliferation and prevented the time-related decline in expression of transcription factors important for maintaining ES cell pluripotency. Significance/Conclusions: These studies suggest that Gs-alpha signaling contributes to ES cell proliferation and pluripotency and provide a framework for further investigation of GPCRs in ES cells