Detecting chiral gravity with the pure pseudospectrum reconstruction of the cosmic microwave background polarized anisotropies

We consider the possible detection of parity violation at the linear level in gravity using polarized anisotropies of the cosmic microwave background. Since such a parity violation would lead to non-zero TB and EB correlations, this makes those odd-parity angular power spectra a potential probe of parity violation in the gravitational sector. These spectra are modeled incorporating the impact of lensing and we explore their possible detection in the context of small-scale (balloon-borne or ground-based) experiments and a future satellite mission dedicated to B-mode detection. We assess the statistical uncertainties on their reconstruction using mode-counting and a (more realistic) pure pseudospectrum estimator approach. Those uncertainties are then translated into constraints on the level of parity asymmetry. We found that detecting chiral gravity is impossible for ongoing small-scale experiments. However, for a satellite-like mission, a parity asymmetry of at least 50% could be detected at 68% of confidence level, and a parity asymmetry of 100% is measurable with at least a confidence level of 95%. We also assess the impact of a possible miscalibration of the orientation of the polarized detectors, leading to spurious TB and EB cross-correlations. We show that in the context of pseudospectrum estimation of the angular power spectra, self-calibration of this angle could significantly reduce the statistical significance of the measured level of parity asymmetry (by e.g. a factor ~2.4 for a miscalibration angle of 1 degree). For chiral gravity and assuming a satellite mission dedicated to primordial B-mode, a non detection of the TB and EB correlation would translate into an upper bound on parity violation of 39% at 95% confidence level for a tensor-to-scalar ratio of 0.2, excluding values of the (imaginary) Barbero-Immirzi parameter comprised between 0.2 and 4.9 at 95% CL.Comment: 21 pages, 6 figures, accepted for publication in Phys. Rev. D (typos and references corrected

Weyl chamber flow on irreducible quotients of products of PSL(2,R)

International audienceWe study the topological dynamics of the action of the diagonal subgroup on quotients Gamma\PSL(2,R)*PSL(2,R), where Gamma is an irreducible lattice. Closed orbits are described and a set of points of dense orbit is explicitly given. Such properties are expressed using the Furstenberg boundary of the symmetric space H*H

Safety and clinical activity of the Notch inhibitor, crenigacestat (LY3039478), in an open-label phase I trial expansion cohort of advanced or metastatic adenoid cystic carcinoma

Background Deregulated Notch signaling is implicated in multiple cancers. The phase I trial (I6F-MC-JJCA) investigated the safety and anti-tumor activity of crenigacestat (LY3039478), a selective oral Notch inhibitor, in an expansion cohort of patients with adenoid cystic carcinoma (ACC) who received the dose-escalation-recommended phase 2 dose (RP2D), established previously (Massard C, et al., Annals Oncol 2018, 29:1911-17). Methods Patients with advanced or metastatic cancer, measurable disease, ECOG-PS ≤1, and baseline tumor tissue were enrolled. Primary objectives were to identify a safe RP2D, confirm this dose in expansion cohorts, and document anti-tumor activity. Secondary objectives included safety and progression-free survival (PFS). The ACC expansion cohort received the RP2D regimen of 50 mg crenigacestat thrice per week in a 28-day cycle until disease progression or other discontinuation criteria were met. Results Twenty-two patients with ACC were enrolled in the expansion cohort (median age of 60 years). Median treatment duration was 3 cycles with 6 patients remaining on treatment. There were no objective responses; 1 (5%) patient had an unconfirmed partial response. Disease control rate was 73% and 4 patients had stable disease ≥6 months. Median PFS was 5.3 months (95%CI: 2.4-NE)) for the 22 patients; and 7.7 months (95%CI: 4.0-NR) and 2.4 months (95%CI: 1.1-NE) in the subgroup of patients in second-line (n = 7) or ≥ third-line (n = 9), respectively. Frequent treatment-related-adverse events (all grades) included diarrhea, fatigue, vomiting, decreased appetite, dry mouth, and dry skin. There were no new safety signals. Conclusion The crenigacestat RP2D regimen induced manageable toxicity and limited clinical activity, without confirmed responses, in heavily pretreated patients with ACC

Translational Medicine is developing in China: A new venue for collaboration

Translational Medicine is an emerging area comprising multidisciplinary Research from basic sciences to medical applications well summarized by the Bench-to-Beside concept; this entails close collaboration between clinicians and basic scientists across institutes. We further clarified that Translational Medicine should be regarded as a two-way road: Bench-to-Bedside and Bedside-to-Bench, to complement testing of novel therapeutic strategies in humans with feedback understanding of how they respond to them. It is, therefore, critical and important to define and promote Translational Medicine among clinicians, basic Researchers, biotechnologists, politicians, ethicists, sociologists, investors and coordinate these efforts among different Countries, fostering aspects germane only to this type of Research such as, as recently discussed, biotechnology entrepreneurship. Translational Medicine as an inter-disciplinary science is developing rapidly and widely and, in this article, we will place a special emphasis on China

First case of human gongylonemosis in France

Gongylonema spp. are cosmopolitan spirurid nematodes that are common parasites of wild and domesticated mammals and birds. Gongylonema pulchrum Molin, 1857 is most common in ruminants, where it invades mucosa and submucosa of the mouth, tongue, oesophagus and forestomachs. It extremely rarely occurs in man, and fewer than 60 cases have been reported worldwide. We report a case from the Alsace region, which appears to be the first case of human gongylonemosis described in France. Les nématodes du genre Gongylonema sont des spiruridés cosmopolites parasites fréquents dans de nombreux mammifères et oiseaux sauvages ou domestiques. Gongylonema pulchrum Molin, 1857 est l’espèce la plus souvent rapportée chez les ruminants, dans la muqueuse et la sous-muqueuse de leur bouche, langue, œsophage et rumen. Il n’est que très exceptionnellement retrouvé chez l’homme. Moins de 60 cas ont été décrits à travers le monde. Nous rapportons dans cet article le premier cas français, découvert en Alsace