21 research outputs found
Effect of fibre treatments on interfacial shear strength of hemp fibre reinforced polylactide and unsaturated polyester composites
Surface treatment of hemp fibres was investigated as a means of improving interfacial shear strength (IFSS) of hemp fibre reinforced polylactide (PLA) and unsaturated polyester (UPE) composites. Fibres were treated with sodium hydroxide, acetic anhydride, maleic anhydride and silane. A combined treatment using sodium hydroxide and silane was also carried out. IFSS of PLA/hemp fibre samples increased after treatment, except in the case of maleic anhydride treatment. Increased IFSS could be explained by better bonding of PLA with treated fibres and increased PLA transcrystallinity. The highest IFSS was 11.4 MPa which was obtained for the PLA/alkali treated fibre samples. IFSS of UPE/hemp fibre samples increased for all treated fibres. This is believed to be due to the improvement of chemical bonding between the treated fibres and the UPE as supported by FT-IR results. The highest IFSS (20.3 MPa) was found for the combined sodium hydroxide and silane treatment fibre/UPE samples
Influence of loading rate, alkali fibre treatment and crystallinity on fracture toughness of random short hemp fibre reinforced polylactide bio-composites
Plane-strain fracture toughness (KIc) of random short hemp fibre reinforced polylactide (PLA) bio-composites was investigated along with the effect of loading rate, fibre treatment and PLA crystallinity. Fracture toughness testing was carried out at loading rates varying from 0.5 to 20 mm/min using single-edge-notched bending specimens with 0 to 30 wt% fibre. KQ (trial KIc) of composites decreased as loading rate increased, until stabilising to give KIc values at a loading rate of 10 mm/min and higher. The reduction of crazing and stress whitening, as well as a more direct crack path observed in PLA samples combined with reduced plastic deformation observed in composites provided explanation for this reduction. KIc of composites was found to decrease with increased fibre content and fibre treatment with sodium hydroxide. Studies controlling the degree of PLA crystallinity by heat treatment or âannealingâ showed that reduction of KIc can be attributed to increased crystallinity
Hemp fibre reinforced poly(lactic acid) composites
The potential of hemp fibre as a reinforcing material for Poly(lactic acid) (PLA) was investigated. Good interaction between hemp fibre and PLA resulted in increases of 100% for Youngâs modulus and 30% for tensile strength of composites containing 30 wt% fibre. Different predictive ârule of mixturesâ models (e.g. Parallel, Series and Hirsch) were assessed regarding the dependence of tensile properties on fibre loading. Limited agreement with models was observed. Differential scanning calorimetry (DSC) and x-ray diffraction (XRD) studies showed that hemp fibre increased the degree of crystallinity in PLA composites
Effect of various chemical treatments on the fibre structure and tensile properties of industrial hemp fibres
Industrial hemp fibres were treated with sodium hydroxide, acetic anhydride, maleic anhydride and silane to investigate the influence of treatment on the fibre structure and tensile properties. It was observed that the average tensile strength of sodium hydroxide treated fibres slightly increased compared with that of untreated fibres, which was believed to be as a result of increased cellulose crystallinity. The average tensile strength of acetic anhydride, maleic anhydride, silane and combined sodium hydroxide and silane treated fibres slightly decreased compared with that of untreated fibres, which was believed to be as a result of decreased cellulose crystallinity. However, the average Youngâs modulus of all treated fibres increased compared with untreated fibres. This was considered to be as a result of densification of fibre cell walls due to the removal of non-cellulosic components during treatment
Fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin with gemtuzumab ozogamicin improves event-free survival in younger patients with newly diagnosed aml and overall survival in patients with npm1 and flt3 mutations
Purpose
To determine the optimal induction chemotherapy regimen for younger adults with newly diagnosed AML without known adverse risk cytogenetics.
Patients and Methods
One thousand thirty-three patients were randomly assigned to intensified (fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin [FLAG-Ida]) or standard (daunorubicin and Ara-C [DA]) induction chemotherapy, with one or two doses of gemtuzumab ozogamicin (GO). The primary end point was overall survival (OS).
Results
There was no difference in remission rate after two courses between FLAG-Ida + GO and DA + GO (complete remission [CR] + CR with incomplete hematologic recovery 93% v 91%) or in day 60 mortality (4.3% v 4.6%). There was no difference in OS (66% v 63%; P = .41); however, the risk of relapse was lower with FLAG-Ida + GO (24% v 41%; P < .001) and 3-year event-free survival was higher (57% v 45%; P < .001). In patients with an NPM1 mutation (30%), 3-year OS was significantly higher with FLAG-Ida + GO (82% v 64%; P = .005). NPM1 measurable residual disease (MRD) clearance was also greater, with 88% versus 77% becoming MRD-negative in peripheral blood after cycle 2 (P = .02). Three-year OS was also higher in patients with a FLT3 mutation (64% v 54%; P = .047). Fewer transplants were performed in patients receiving FLAG-Ida + GO (238 v 278; P = .02). There was no difference in outcome according to the number of GO doses, although NPM1 MRD clearance was higher with two doses in the DA arm. Patients with core binding factor AML treated with DA and one dose of GO had a 3-year OS of 96% with no survival benefit from FLAG-Ida + GO.
Conclusion
Overall, FLAG-Ida + GO significantly reduced relapse without improving OS. However, exploratory analyses show that patients with NPM1 and FLT3 mutations had substantial improvements in OS. By contrast, in patients with core binding factor AML, outcomes were excellent with DA + GO with no FLAG-Ida benefit
Improvement of mechanical performance of industrial hemp fibre reinforced polylactide biocomposites
In this work, mechanical properties of chemically treated random short fibre and aligned long hemp fibre reinforced PLA composites were investigated over a range of fibre content (0â40 wt.%). It was found that tensile strength, Youngâs modulus and impact strength of short hemp fibre reinforced PLA composites increased with increased fibre content. Alkali and silane fibre treatments were found to improve tensile and impact properties which appears to be due to good fibre/matrix adhesion and increased matrix crystallinity. A 30 wt.% alkali treated fibre reinforced PLA composite (PLA/ALK) with a tensile strength of 75.5 MPa, Youngâs modulus of 8.18 GPa and impact strength of 2.64 kJ/m2 was found to be the best. However, plane-strain fracture toughness and strain energy release rate decreased with increased fibre content. The mechanical properties of the PLA/ALK composites were increased further due to alignment of long fibres
Characterisation of hemp fibre reinforced Poly(Lactic Acid) composites
In this work, the mechanical properties including tensile strength, flexural strength, impact strength and fracture toughness of the PLA/hemp composites were investigated over a range of fibre content (0-30 wt.%). It was observed that, the tensile strength and Young's modulus of the composites increased with increased fibre content. The flexural strength did not increase with fibre reinforcement, however, the flexural modulus of the composites increased significantly. Impact strength of the composites increased up to 20 wt. % fibre loading, however, further increased fibre loading caused a reduction of impact strength. KIc and GIc values decreased with increased fibre content
Flexural properties of hemp fibre reinforced polylactide and unsaturated polyester composites
In this work, flexural strength and flexural modulus of chemically treated random short and aligned long hemp fibre reinforced polylactide and unsaturated polyester composites were investigated over a range of fibre content (0â50 wt%). Flexural strength of the composites was found to decrease with increased fibre content; however, flexural modulus increased with increased fibre content. The reason for this decrease in flexural strength was found to be due to fibre defects (i.e. kinks) which could induce stress concentration points in the composites during flexural test, accordingly flexural strength decreased. Alkali and silane fibre treatments were found to improve flexural strength and flexural modulus which could be due to enhanced fibre/matrix adhesion
Analysis of mechanical properties of hemp fibre reinforced unsaturated polyester composites
Different chemically treated hemp fibre reinforced unsaturated polyester composites were investigated over a range of fibre content (0â60 wt%). Although Youngâs modulus of all the short fibre reinforced unsaturated polyester composites was found to be higher than that of unreinforced unsaturated polyester; however, tensile strength of the composites exceeded that of the unsaturated polyester matrix only for the combined alkali- and silane-treated fibre composites at 40 wt% fibre content. The decrease in tensile strength of the composites could be attributed to stress concentrations caused by the fibres in conjunction with the brittle matrix. Impact strength of all the treated fibre composites was higher than that of the untreated fibre composites at all fibre contents. KIc and GIc of the composites decreased initially and thenincreased as the fibre content increased because more and more fibres being available to pull-out. The mechanical properties of the composites were increased further due to the alignment of long fibres