Part of the graphic output of the deconvolution analysis in a male control subject, the upper panel shows the original serum PRL concentrations (µg/L) and the fitted concentration curve (interrupted line).

<p>Asterisks denote pulse onsets, and the rhomboids the time of waveform switch. Time 0 min is 0900 hr. The second panel shows the secretion rate in µg/L.min. The third panel represents the secretion rate within bursts (normalized secretion over time) for the daytime (interrupted line) and nighttime (continuous line), stressing the difference in time at which the maximal secretion rate is reached. The lowest plot shows the statistical distribution of the interpulse delays.</p

Multiple linear regression between age, gender and total logarithmically transformed PRL secretion, calculated by deconvolution analysis.

<p>Data were obtained in 74 healthy subjects, who underwent 24-h blood sampling at 10-min intervals. Male subjects are shown as triangles, female subjects as circles. Data points above the regression plane are open, below they are closed.</p

Cosinor analysis of the 24-h serum prolactin profiles in healthy subjects.

<p>Data are shown as mean ± SEM. Statistical comparisons were made with the Student's t-test for unpaired data.</p

Multiple linear regression between age, gender and mean serum PRL concentration.

<p>Data were obtained in 74 healthy subjects, who underwent 24-h blood sampling at 10-min intervals. Male subjects are shown as triangles, female subjects as circles. Data points above the regression plane are open, below they are closed.</p

Multiple linear regression between age, BMI and the acrophase of the PRL rhythm.

<p>Data points above the regression plane are open, below the plane they are closed. There were no gender differences in acrophase.</p

Box plots of the pulsatile PRL secretion during day time and during the period with lights off (2300 -0700 h).

<p>Differences between men and women were calculated with the Kolmogorov-Smirnov test.</p

Baseline subject characteristics.

<p>Data are shown as median and range. Statistical evaluation was done with the Kolmogorov-Smirnov test.</p

Multiple linear regression between age, gender and maximal PRL concentration in the 24-h serum profile.

<p>Data were obtained in 74 healthy subjects, who underwent 24-h blood sampling at 10-min intervals. Male subjects are shown as triangles, female subjects as circles. Data points above the regression plane are open, below they are closed.</p

Twenty-four hour serum PRL concentration profiles in 41 healthy women and 33 healthy men.

<p>Blood samples were drawn every 10 min. Data are shown as mean, and the bars represent the SEM. The period with lights off (shown as the black horizontal bar) was between 2300 and 0700 h.</p

Overview of association metrics of ACTH and TSH.

<p>The shaded area around the white lines marks the 95% confidence interval of the mean, the thin lines show the individual results. The metrics point at a relation at two optima at lags −42 and 22.</p