Additional file 1: Table S1. of Early versus late tracheostomy after decompressive craniectomy for stroke

Bivariate analysis for ventilator associated pneumonia. Table S2. Outcome analysis with and without tracheostomy using proposed propensity score. (DOCX 15 kb

Summary of diagnostic testing results by village over the 24-month study period.

<p>Summary of diagnostic testing results by village over the 24-month study period.</p

Comparison of predicted confirmed malaria case rates (CMCR) at specified test positivity rates (TPR) using both linear and exponential growth regression models.

<p>Comparison of predicted confirmed malaria case rates (CMCR) at specified test positivity rates (TPR) using both linear and exponential growth regression models.</p

Regression models of diagnostic test positivity rates (TPR) as predictors of confirmed malaria case rate (CMCR).

<p>Regression models of diagnostic test positivity rates (TPR) as predictors of confirmed malaria case rate (CMCR).</p

Linear (red) and exponential (green) models of the relationship between confirmed malaria case rate and test positivity rate at 6-month measurement intervals.

<p>Linear (red) and exponential (green) models of the relationship between confirmed malaria case rate and test positivity rate at 6-month measurement intervals.</p

Sensitivity models exploring the quantitative relationship between test positivity rate (TPR) and confirmed malaria case rate (CMCR).

<p>Sensitivity models exploring the quantitative relationship between test positivity rate (TPR) and confirmed malaria case rate (CMCR).</p

sj-docx-2-cho-10.1177_18632521241229954 – Supplemental material for Optimizing calibration of modern skeletal maturity systems

Supplemental material, sj-docx-2-cho-10.1177_18632521241229954 for Optimizing calibration of modern skeletal maturity systems by Ryan J Furdock, Andrew J Moyal, Alexander Benedick, Feng-Chang Lin, Yajing Hao, Daniel R Cooperman, James O Sanders and Raymond W Liu in Journal of Children’s Orthopaedics</p

Shared TH2 between Malawi and the Gambia.

<p>Shared TH2 between Malawi and the Gambia.</p

TH2 and TH3 Pairings from Malawi and the Gambia.

<p>(a) This figure shows all TH2-x/TH3-y haplotype pairings comparing observed and expected. Those that are that are statistically over and under represented based upon our contingency table analysis (p≤0.00009 for Malawi and p≤0.003 for the Gambia) are colored blue. (b) The data shown are for those pairings in Malawi (blue) and the Gambia (green) that are either observed >5 times in our data, or those predicted to occur >5 times based upon our contingency analysis. Each pairing is represented a unique symbol. Of note, three pairings (TH2-1/TH3-1, TH2-6/TH3-1, and TH2-3/TH3-2) were over represented in both populations. In both figures, the diagonal line represents if there were non-random association of pairings based on predicted and observed values. Points above the line represent pairing over represented in the population, while those represented below the line are those under represented in the population. A complete list of these significant pairings is provided in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0062427#pone.0062427.s005" target="_blank">Table S2</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0062427#pone.0062427.s006" target="_blank">S3</a>.</p

Calculated ΔΔG of observed polymorphic amino mutations from the ancestral amino acid residue compared relative to median of all possible mutations at each position.

<p>Free energy changes of polymorphisms in TH2 and TH3 are shown relative to the median change from all 19 substitutions from the predicted ancestral allele determined from <i>Plasmodium sp.</i> phylogeny. Mutations that have higher energy than the median are shown in red, while those with lower energy are shown in blue. Positive values represent increases in free energy and thermodynamic instability while negative values represent decline in free energy and greater stability. Neutral sequence where energetics have no effect would be expected to occur 50/50 above and below the median, while conservation of intramolecular function would be expected to minimize entropy and lead to lower energy states. Intermolecular interactions can lead to selection for less favorable states which are significantly enriched in the observed polymorphisms (17 increased vs 5 decreased, p = 0.00845).</p