Concert recording 2017-10-11

[Track 1]. Fantasy on Acteon / J.B. Arban -- [Track 2]. Fantasiestücke. I. Zart und mit Ausdruck [Track 3]. II. Lebhaft, leicht / Robert Schumann -- [Track 4]. El Moncayo / Jan Hadermann -- [Track 5]. Concerto for tuba. I. Allegro moderato / John Williams -- [Track 6]. Sonata in F minor. I. Triste [Track 7]. II. Allegro / G.F. Telemann -- [Track 8]. Suite no. 3 for solo cello, BWV 1009. Prelude / J.S. Bach -- [Track 9]. Fantasy for tuba / Malcolm Arnold -- [Tracks 10-12]. Sonata in F major / Benedetto Marcello

Concert recording 2018-04-29a

[Track 1]. Toccata / Girolamo Frescobaldi arranged by Joseph Skillen -- [Track 2]. Winds. I. Khamsin [Track 3]. II. Zephyrs [Track 4]. III. Bora [Track 5]. IV. Doldrums [Track 6]. V. Sirocco / Rodger Vaughan -- [Track 7]. David and Goliath / Michael Forbes -- [Track 8]. Down in the river / traditional arranged by David Gluck -- [Track 9]. Ball of fire / Steven Smalley -- [Track 10]. Ludus / Vaclav Nelhybel -- [Track 11]. Let love be heard / Jake Runestad arranged by Cody Hutchison -- [Track 12]. Meltdown / Jonathan Sass

Concert recording 2018-02-19

[Track 1]. The barber of Seville overture / Gioachino Rossini arranged by Hutchison -- [Track 2]. Capriccio for tuba and marimba / William Penn -- [Track 3]. Galgenlieder, op. 129. I. Das Geburtslied [Track 4]. II. Das Hemmed [Track 5]. III. Die zwei Wurzeln IV. Die Luft [Track 6]. V. Fisches Nachtgesang (tuba solo) [Track 7]. VI. Igel und Agel [Track 8]. VII. Die beiden Esel [Track 9]. VIII. Das Gebet / Jan Koetsier -- [Track 10]. Concerto per tuba e 4 corni. I. Introduction - allegro [Track 11]. II. Adagio [Track 12]. III. Allegro con spirito / Corrado Maria Saglietti -- [Track 13]. David and Goliath / Mike Forbes

Concert recording 2017-03-06

[Track 1]. Triumph of the demon gods / John Stevens -- [Track 2]. Sonata in F minor. Andante cantabile / Georg Philipp Telemann -- [Track 3]. Sonata in F minor. Allegro / Georg Philipp Telemann -- [Track 4]. Sketches. Spirited / Michael McFarland -- [Track 5]. Sketches. Slow and expressive / Michael McFarland -- [Track 6]. Sonata for unaccompanied euphonium. Introduction and allegro / Fred Clinard -- [Track 7]. Sonata for unaccompanied euphonium. Song / Fred Clinard -- [Track 8]. Tuba concerto. Allegro moderato / Edward Gregson -- [Track 9]. Sonata 1 in F major. Largo Allegro / Benedetto Marcello -- [Track 10]. Suite for cello no. 4, BWV 1010. Bourree 1 Bourree II / Johann Sebastian Bach -- [Track 11]. Summer isles / Philip Sparke -- [Track 12]. Tuba suite. Prelude Hornpipe Sarabande Bourree Mazurka / Gordon Jacob -- [Track 13]. Soliloquy IX / Christopher Wiggins -- [Track 14]. Suite for unaccompanied tuba / Walter Hartley

Concert recording 2017-11-28

[Track 1]. Bill Bailey / Hughie Cannon arranged by James Garrett -- [Track 2]. Second suite. I. March [Track 3]. II. Song without words, I\u27ll love my love / Gustav Holst arranged by Cody Hutchison -- [Track 4]. Deutschland uber alles / Franz Joseph Haydn arranged by Eugene Anderson -- [Track 5]. Geleit from Three pieces / Johannes Brahms translated by William R. Lee -- [Track 6]. Belle of Chicago march / John Philip Sousa arranged by Skip Gray -- [Track 7]. Three preludes from op. 34. No. 14 [Track 8]. No. 7 [Track 9]. No. 16 / Dmitri Shostakovich arranged by Rauch -- [Track 10]. Tuba Sunday / traditional arranged by Gerald Sloan -- [Track 11]. Quartet for tubas / Sy Brandon -- [Track 12.] Cherokee / John Schooley -- [Track 13]. Moondance / John Stevens -- [Track 14]. Amazing grace / traditional arranged by David Uber

Concert recording 2014-11-18

[Track 01]. Mars from The planets / Gustav Holst ; arranged by David Butler -- [Track 02]. Consortium / John Cheetham -- [Track 03]. Axis / Kevin McKenzie -- [Track 04]. Scherzo from A midsummer night\u27s dream / Felix Mendelssohn ; arranged by Michael Forbes -- [Track 05]. Nocturne / Rimsky-Korsakov -- [Track 06]. Ave Maria / Franz Biebl ; arranged by Mark Jenkins -- [Track 07]. Fearful symmetry / Kenyon Wilson

Concert recording 2018-02-09

[Track 1]. Marche á huit instrumens á vent / Nannette Streicher -- [Track 2]. Dixtuor pour instruments á vent. I. Allegro moderato II. Moderato [Track 3]. III. Andante - Allegro scherzando [Track 4]. IV. Cantabile [Track 5]. V. Allegro risoluto / Claude Arrieu, née Louise Marie Simon -- [Track 6]. Octet for windinstruments / Tera de Marez Oyens -- [Track 7]. The unfortunate traveller, suite for brass band. I. Introduction II. Scherzo [Track 8]. III. Interlude [Track 9]. IV. March / Imogen Holst

Targeted Disruption of the PME-1 Gene Causes Loss of Demethylated PP2A and Perinatal Lethality in Mice

Phosphoprotein phosphatase 2A (PP2A), a major serine-threonine protein phosphatase in eukaryotes, is an oligomeric protein comprised of structural (A) and catalytic (C) subunits to which a variable regulatory subunit (B) can associate. The C subunit contains a methyl ester post-translational modification on its C-terminal leucine residue, which is removed by a specific methylesterase (PME-1). Methylesterification is thought to control the binding of different B subunits to AC dimers, but little is known about its physiological significance in vivo.Here, we show that targeted disruption of the PME-1 gene causes perinatal lethality in mice, a phenotype that correlates with a virtually complete loss of the demethylated form of PP2A in the nervous system and peripheral tissues. Interestingly, PP2A catalytic activity over a peptide substrate was dramatically reduced in PME-1(-/-) tissues, which also displayed alterations in phosphoproteome content.These findings suggest a role for the demethylated form of PP2A in maintenance of enzyme function and phosphorylation networks in vivo