5,277 research outputs found

    Their Sleep Is To Be Desecrated : California\u27s Central Valley Project and the Wintu People of Northern California, 1938- 1943

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    The morning of July 14, 1944, was intended to be a moment of celebration for the City of Redding, California. Secretary of the Interior Harold L. Ickes had been scheduled to arrive in the booming city to dedicate Shasta Dam, a national reclamation project of great pride to local citizens and construction workers. Just days prior, however, the dedication ceremony had been canceled due to the inability of Ickes to leave Washington D.C.. Instead, a small group of U.S. Bureau of Reclamation (BOR) officials, Sacramento Municipal Utility District (SMUD) officials, and local city officials quietly gathered within the dam\u27s $19,400,000 power plant. A BOR official flipped a switch to start one of the plant\u27s two massive generators, sending a surge of 120,000 watts of hydroelectricity into California\u27s transmission lines and the Pacific, Gas, and Electric (PG&E) distribution system. This energy would fuel the West\u27s war industries and the federal defense effort in World War II. Though without fanfare, the switching event signaled the official start of commercial production of power from the world\u27s second largest dam and keystone of the Central Valley Project (CVP). From Washington, D.C., the event was heralded by BOR Commissioner Harry W. Bashore as a milestone in the fulfillment of visions Californians have had for nearly 100 years.

    Housing Wealth and Retirement Timing

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    We use data from the Health and Retirement Study (HRS) and the Office of Housing Enterprise Oversight to measure the effect of changes in housing wealth on retirement timing. Using cross-MSA variation in house-price movements to identify wealth effects on retirement timing, we find evidence that such wealth effects are present. According to some specifications the rate of transition into retirement increases in the presence of positive housing wealth shocks. In addition, we use data on expected age of retirement to measure the impact of housing wealth shocks on expectations about retirement timing. Using renters as a control for heterogeneity in local amenities and using individual fixed effects to control for unobserved individual heterogeneity, we find that a 10% increase in housing wealth is associated with a reduction in expected retirement age of between 3.5 and 5 months.

    Development of a micrometeoroid accelerator Final report

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    Design and performance of arc plasma micrometeoroid accelerator system

    Characterization of the ZFX family of transcription factors that bind downstream of the start site of CpG island promoters

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    Our study focuses on a family of ubiquitously expressed human C₂H₂ zinc finger proteins comprised of ZFX, ZFY and ZNF711. Although their protein structure suggests that ZFX, ZFY and ZNF711 are transcriptional regulators, the mechanisms by which they influence transcription have not yet been elucidated. We used CRISPR-mediated deletion to create bi-allelic knockouts of ZFX and/or ZNF711 in female HEK293T cells (which naturally lack ZFY). We found that loss of either ZFX or ZNF711 reduced cell growth and that the double knockout cells have major defects in proliferation. RNA-seq analysis revealed that thousands of genes showed altered expression in the double knockout clones, suggesting that these TFs are critical regulators of the transcriptome. To gain insight into how these TFs regulate transcription, we created mutant ZFX proteins and analyzed them for DNA binding and transactivation capability. We found that zinc fingers 11–13 are necessary and sufficient for DNA binding and, in combination with the N terminal region, constitute a functional transactivator. Our functional analyses of the ZFX family provides important new insights into transcriptional regulation in human cells by members of the large, but under-studied family of C₂H₂ zinc finger proteins

    ミスト蒸発冷却の研究とその応用

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    博士(工学)大阪市立大
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