Presentation_2_First-line monodrug chemotherapy in low-risk gestational trophoblastic neoplasia: a network meta-analysis.pptx

ObjectiveThe efficacy of the first-line monodrug chemotherapy has been generally established for low-risk GTN. Most patients can achieve a complete response after the first-line monodrug chemotherapy. However, which monodrug chemotherapy regimen is better for individual patients with GTN is not yet certain. This study aimed to assess the efficacy of first-line monodrug chemotherapy in low-risk gestational trophoblastic neoplasia (GTN).MethodDatabases, including PubMed, Embase, Web of Science, and Cochrane Library, were searched from inception to November 1, 2022, for case–control studies on first-line monodrug chemotherapy in GTN. Network meta-analysis was performed to compare the efficacy outcome of six monodrug chemotherapy regimens in GTN, with a complete response rate as the endpoint.ResultTwenty-four studies were considered eligible, including 9 randomized controlled trials (RCTs) and 15 non-RCTs. A total of 3344 patients with low-risk GTN were involved. Six monodrug chemotherapy regimens were included and analyzed. In descending order of efficacy, these six regimens were VP-16 (5 days), ACT-D (5 days), MTX (5 days), ACT-D (1.25 mg/m2), MTX (8 days), and MTX (30–50 mg/m2) in all study, and five regimens were ACT-D (5 days), MTX (5 days), ACT-D (1.25 mg/m2), MTX (8 days), and MTX (30–50 mg/m2) in RCT.ConclusionAmong the six first-line monodrug chemotherapy regimens for low-risk GTN in all study, VP-16 (5 days) was the best in terms of efficacy. And five regimens in RCT, ACT-D was the best. However, the finding needs to be validated through more high-quality clinical studies.</p

Table_1_First-line monodrug chemotherapy in low-risk gestational trophoblastic neoplasia: a network meta-analysis.docx

ObjectiveThe efficacy of the first-line monodrug chemotherapy has been generally established for low-risk GTN. Most patients can achieve a complete response after the first-line monodrug chemotherapy. However, which monodrug chemotherapy regimen is better for individual patients with GTN is not yet certain. This study aimed to assess the efficacy of first-line monodrug chemotherapy in low-risk gestational trophoblastic neoplasia (GTN).MethodDatabases, including PubMed, Embase, Web of Science, and Cochrane Library, were searched from inception to November 1, 2022, for case–control studies on first-line monodrug chemotherapy in GTN. Network meta-analysis was performed to compare the efficacy outcome of six monodrug chemotherapy regimens in GTN, with a complete response rate as the endpoint.ResultTwenty-four studies were considered eligible, including 9 randomized controlled trials (RCTs) and 15 non-RCTs. A total of 3344 patients with low-risk GTN were involved. Six monodrug chemotherapy regimens were included and analyzed. In descending order of efficacy, these six regimens were VP-16 (5 days), ACT-D (5 days), MTX (5 days), ACT-D (1.25 mg/m2), MTX (8 days), and MTX (30–50 mg/m2) in all study, and five regimens were ACT-D (5 days), MTX (5 days), ACT-D (1.25 mg/m2), MTX (8 days), and MTX (30–50 mg/m2) in RCT.ConclusionAmong the six first-line monodrug chemotherapy regimens for low-risk GTN in all study, VP-16 (5 days) was the best in terms of efficacy. And five regimens in RCT, ACT-D was the best. However, the finding needs to be validated through more high-quality clinical studies.</p

Presentation_1_First-line monodrug chemotherapy in low-risk gestational trophoblastic neoplasia: a network meta-analysis.pptx

ObjectiveThe efficacy of the first-line monodrug chemotherapy has been generally established for low-risk GTN. Most patients can achieve a complete response after the first-line monodrug chemotherapy. However, which monodrug chemotherapy regimen is better for individual patients with GTN is not yet certain. This study aimed to assess the efficacy of first-line monodrug chemotherapy in low-risk gestational trophoblastic neoplasia (GTN).MethodDatabases, including PubMed, Embase, Web of Science, and Cochrane Library, were searched from inception to November 1, 2022, for case–control studies on first-line monodrug chemotherapy in GTN. Network meta-analysis was performed to compare the efficacy outcome of six monodrug chemotherapy regimens in GTN, with a complete response rate as the endpoint.ResultTwenty-four studies were considered eligible, including 9 randomized controlled trials (RCTs) and 15 non-RCTs. A total of 3344 patients with low-risk GTN were involved. Six monodrug chemotherapy regimens were included and analyzed. In descending order of efficacy, these six regimens were VP-16 (5 days), ACT-D (5 days), MTX (5 days), ACT-D (1.25 mg/m2), MTX (8 days), and MTX (30–50 mg/m2) in all study, and five regimens were ACT-D (5 days), MTX (5 days), ACT-D (1.25 mg/m2), MTX (8 days), and MTX (30–50 mg/m2) in RCT.ConclusionAmong the six first-line monodrug chemotherapy regimens for low-risk GTN in all study, VP-16 (5 days) was the best in terms of efficacy. And five regimens in RCT, ACT-D was the best. However, the finding needs to be validated through more high-quality clinical studies.</p

Average weight of enzymes in the compressed Archaea graphs, and average importance of enzymes in the compressed part shared by two domains.

<p>Average weight of enzymes in the compressed Archaea graphs, and average importance of enzymes in the compressed part shared by two domains.</p

Correlation of weights between domains.

<p>Correlation of weights between domains.</p

Constructing weighted metabolic networks.

<p>The metabolism of each species is a specific instantiation of the super-metabolism. Nodes in grey mean that they do not occur in a specific genome.</p

Correlation between taxonomic and isoenzymatic weights.

<p>Correlation between taxonomic and isoenzymatic weights.</p

Isoenzymatic weight in a section of glycolysis.

<p>The weights for <i>Archaea</i> are in red, the weights for <i>Eubacteria</i> are in blue.</p

The correlations of compression results between domains.

<p>The correlations of compression results between domains.</p

A example of weighted graph compression based on node weights.

<p>Node weights are in the parenthesis.</p