Spitzer 70 Micron Source Counts in GOODS-North

We present ultradeep Spitzer 70 μm observations of GOODS-North (Great Observatories Origins Deep Survey). For the first time, the turnover in the 70 μm Euclidean-normalized differential source counts is observed. We derive source counts down to a flux density of 1.2 mJy. From the measured source counts and fluctuation analysis, we estimate a power-law approximation of the faint 70 μm source counts of dN/dS ∝ S^−1.6, consistent with that observed for the faint 24 μm sources. An extrapolation of the 70 μm source counts to zero flux density implies a total extragalactic background light (EBL) of 7.4 ± 1.9 nW m^−2 sr^−1. The source counts above 1.2 mJy account for about 60% of the estimated EBL. From fluctuation analysis, we derive a photometric confusion level of σc = 0.30 ± 0.15 mJy (q = 5) for the Spitzer 70 μm band

Deep Herschel view of obscured star formation in the Bullet cluster

We use deep, five band (100–500 μm) data from the Herschel Lensing Survey (HLS) to fully constrain the obscured star formation rate, SFR_(FIR), of galaxies in the Bullet cluster (z = 0.296), and a smaller background system (z = 0.35) in the same field. Herschel detects 23 Bullet cluster members with a total SFRFIR = 144±14 M_☉ yr^(-1). On average, the background system contains brighter far-infrared (FIR) galaxies, with ~50% higher SFRFIR (21 galaxies; 207 ± 9 M_☉ yr^(-1)). SFRs extrapolated from 24 μm flux via recent templates (SFR_(24 µm)) agree well with SFRFIR for ~60% of the cluster galaxies. In the remaining ~40%, SFR24 µm underestimates SFR_(FIR) due to a significant excess in observed S_(100)/S_(24) (rest frame S_(75)/S_(18)) compared to templates of the same FIR luminosity

Sustained release of antimicrobials from double-layer nanofiber mats for local treatment of periodontal disease, evaluated using a new micro flow-through apparatus

Periodontal disease is a widespread chronic condition associated with degradation of periodontal tissues that requires more effective approaches for its treatment. Thus, the aim was to develop a nanodelivery system for local application of antimicrobials, with evaluation in vitro using a newly developed micro flow-through apparatus that simulates local in-vivo conditions in the periodontal pocket: small resting volume, and low gingival crevicular fluid flow rate. We successfully developed a double-layer nanofiber mat composed of a chitosan/ poly(ethylene) oxide nanofiber layer with 30% ciprofloxacin, and a poly(ε-caprolactone) nanofiber layer with 5% metronidazole. The precisely designed composition enabled sustained in-vitro release of the antimicrobials according to their specific drug release mechanisms. The rate-limiting step of ciprofloxacin release was its own low solubility at pH 7.4, when there was excess of solid drug present in the delivery system. In contrast, sustained release of metronidazole was due to slow penetration of dissolution medium through the hydrophobic poly(ε-caprolactone) nanofiber layer. The double-layer nanofiber mat developed showed antibacterial activity against Escherichia coli and Aggregatibacter actinomycetemcomitans based on plate antibiogram assays. The antimicrobial concentrations released from the nanofiber mats determined using the developed apparatus were above the minimal inhibitory concentrations against the periodontal pathogens for up to 7 days, which is valuable information for prediction of the efficacy of the nanodelivery system. Although this apparatus was specifically designed for characterization of formulations associated with treatments for periodontal disease, its applicability is much wide, as for development of any delivery system for application at target sites that have similar local conditions

The Spitzer Archival Far-InfraRed Extragalactic Survey

We present the Spitzer Archival Far-InfraRed Extragalactic Survey (SAFIRES). This program produces refined mosaics and source lists for all far-infrared extragalactic data taken during the more than six years of the cryogenic operation of the Spitzer Space Telescope. The SAFIRES products consist of far-infrared data in two wavelength bands (70 um and 160 um) across approximately 180 square degrees of sky, with source lists containing far-infrared fluxes for almost 40,000 extragalactic point sources. Thus, SAFIRES provides a large, robust archival far-infrared data set suitable for many scientific goals.Comment: 7 pages, 6 figures, published in ApJ

New Optical Insights into the Mass Discrepancy of Galaxy Clusters: The Cases of A1689 and A2218

We analyze the internal structures of clusters A1689 and A2218 by applying a recent development of the method of wavelet analysis, which uses the complete information obtained from optical data, i.e. galaxy positions and redshifts. We find that both clusters show the presence of structures superimposed along the line of sight with different mean redshifts and smaller velocity dispersions than that of the system as a whole, suggesting that the clusters could be cases of the on-going merging of clumps. In the case of A2218 we find an acceptable agreement between our estimate of optical virial mass and X-ray and gravitational lensing masses. On the contrary, in the case of A1689 we find that our mass estimates are smaller than X-ray and gravitational lensing ones at both small and large radii. In any case, at variance with earlier claims, there is no evidence that X-ray mass estimates are underestimated.Comment: 8 pages, 2 eps figures, Use LaTeX2e, accepted by Astrophysical Journal, in press November 1997, Vol.49

Infrared Properties of Radio-Selected Submillimeter Galaxies in the Spitzer First Look Survey Verification Field

We report on submillimeter and infrared observations of 28 radio-selected galaxies in the Spitzer First Look Survey Verification field (FLSV). All of the radio-selected galaxies that show evidence for emission at 850um with SCUBA have Spitzer counterparts at 24um, while only half of the radio-selected galaxies without 850um emission have detectable counterparts at 24um. The data show a wide range of infrared colors (S70/S24 < 5--30, S8/S3.6 < 0.3--4), indicative of a mixture of infrared-warm AGN and cooler starburst dominated sources. The galaxies showing 850um emission have Spitzer flux densities and flux density ratios consistent with the range of values expected for high-redshift (z=1--4) ultraluminous infrared galaxies.Comment: Accepted for Spitzer ApJS Special Edition, 12 pages including 4 figures and 1 tabl

Obscured and unobscured active galactic nuclei in the Spitzer Space Telescope First Look Survey

Selection of active galactic nuclei (AGN) in the infrared allows the discovery of AGN whose optical emission is extinguished by dust. In this paper, we use the Spitzer Space Telescope First Look Survey (FLS) to assess what fraction of AGN with mid-infrared luminosities comparable to quasars are missed in optical quasar surveys due to dust obscuration. We begin by using the Sloan Digital Sky Survey (SDSS) database to identify 54 quasars within the 4 deg^2 extragalactic FLS. These quasars occupy a distinct region in mid-infrared color space by virtue of their strong, red, continua. This has allowed us to define a mid-infrared color criterion for selecting AGN candidates. About 2000 FLS objects have colors consistent with them being AGN, but most are much fainter in the mid-infrared than the SDSS quasars, which typically have 8 micron flux densities, S(8.0), ~1 mJy. We have investigated the properties of the 43 objects with S(8.0) >= 1 mJy satisfying our AGN color selection. This sample should contain both unobscured quasars, and AGN which are absent from the SDSS survey due to extinction in the optical. After removing 16 known quasars, three probable normal quasars, and eight spurious or confused objects from the initial sample of 43, we are left with 16 objects which are likely to be obscured quasars or luminous Seyfert-2 galaxies. This suggests the numbers of obscured and unobscured AGN are similar in samples selected in the mid-infrared at S(8.0)~1 mJy.Comment: To appear in the ApJS Spitzer Special Issu

Characterization of Extragalactic 24micron Sources in the Spitzer First Look Survey

In this Letter, we present the initial characterization of extragalactic 24um sources in the Spitzer First Look Survey (FLS) by examining their counterparts at 8um and R-band. The color-color diagram of 24-to-8 vs. 24-to-0.7um is populated with 18,734 sources brighter than the 3sigma flux limit of 110uJy, over an area of 3.7sq.degrees. The 24-to-0.7um colors of these sources span almost 4 orders of magnitudes, while the 24-to-8um colors distribute at least over 2 orders of magnitudes. In addition to identifying ~30% of the total sample with infrared quiescent, mostly low redshift galaxies, we also found that: (1) 23% of the 24um sources (~1200/sq.degrees) have very red 24-to-8 and 24-to-0.7 colors and are probably infrared luminous starbursts with L(IR)>3x10^(11)Lsun at z>1. In particular, 13% of the sample (660/sq.degrees) are 24um detected only, with no detectable emission in either 8um or R-band. These sources are the candidates for being ULIRGs at z>2. (2) 2% of the sample (85/sq.degrees) have colors similar to dust reddened AGNs, like Mrk231 at z~0.6-3. (3) We anticipate that some of these sources with extremely red colors may be new types of sources, since they can not be modelled with any familiar type of spectral energy distribution. We find that 17% of the 24um sources have no detectable optical counterparts brighter than R limit of 25.5mag. Optical spectroscopy of these optical extremely faint 24um sources would be very difficult, and mid-infrared spectroscopy from the Spitzer would be critical for understanding their physical nature (Abridged).Comment: Accepted for publication in ApJ (Spitzer Special Issue

Invasive fungal infections in patients with acute myeloid leucemia and in those submitted to allogeneic hemopoieticstem cell transplant: who is at highest risk ?

Invasive fungal infections (IFIs) are a growing cause of morbidity and mortality in patients with acute myeloid leukemia (AMLs) and in recipients of allogeneic hemopoietic stem cell transplantation (allo-HSCTs) (1–6). It is widely debated if either allo-HSCTs or AMLs are to be considered at higher risk, but no data comparing the two categories of patients have been reported in literature so far. This cohort study has been conducted from January 1999 to December 2003 in hematology wards located throughout Italy. The study was aimed at evaluating the incidence and mortality for IFIs in adult AMLs and in patients submitted to all types of allo-HSCT procedures; a comparison between the two categories of patients was carried out