1 research outputs found
EFEKTIVITAS NANOEMULSI SEBAGAI PENGHANTAR UBIQUINONE (Q10) DIBANDINGKAN DENGAN EMULSI PADA SEDIAAN KOSMETIKA ANTI AGING (Menggunakan Fase Minyak Olive Oil)
Ubiquinone (Q10) is an endogenous antioxidant. It is lipophilic and practically
insoluble in water. To improve its solubility and penetration, it was formulated
into O/W nanoemulsion. The resulting Q10 nanoemulsion was then physically
characterized for its viscosity, surface tension, morphology, droplet size, and
polydispersity index. In addition, it was conducted a penetration test of Q10 and
effectiveness Q10 as anti aging in nanoemulsion delivery system compared to
Q10 in emulsion using male Wistar rats. From the characterization results, that the
viscosity of Q10 nanoemulsion (10.5 CPas) < Q10 emulsion (16 CPas), the
morphology of droplet Q10 nanoemulsion and Q10 emulsion that are spherical,
and it was found that the droplet size of Q10 nanoemulsion (70.07 ± 12.42 nm) <
Q10 emulsion (21.063 ± 3,57μm), The penetration rate of Q10 in nanoemulsion
and emulsion was observed at 2 hours, 4 hours, and 6 hours after treatment. The
result was known that the penetration rate of Q10 in nanoemulsion (174.49 μm/h)
> Q10 in emulsion (20.429 μm/h). Effectivness as anti aging using the number of
fibroblast and collagen density. The number of fibroblasts were obtained in Q10
nanoemulsion (39 ± 6,04) > Q10 emulsion (23 ± 2,07). Collagen density test
results on Q10 nanoemulsi (1.8 ± 0.44)> Q10 emulsion (1.6 ± 0.54)