Effect of Contrast-Enhanced Echocardiograms on the Prognosis of Infective Endocarditis

Objective - Infective endocarditis (IE) is an infectious disease of the cardiac valves where bacteria colonize the valves; typically, via the formation of vegetations. Recent research has shown that the microbubbles in a contrast-enhanced ultrasound (CEUS) examination can move and dislodge bacterial vegetations in vitro. This study investigated whether CEUS resulted in faster resolution of IE in vivo by dislodging the vegetations. Methods - This IRB approved retrospective study reviewed 36 patients who were diagnosed with IE via echocardiography. Data was sourced from patients within the Jefferson University Hospital’s Cardiology EMR system by searching for contrast and vegetation from January 1st, 2013 – January 1st, 2018. Fifteen patients were not given contrast, whereas 21 patients were given contrast via agitated saline (n=16) or an ultrasound contrast agent (n=5). All patients received an echocardiogram after blood cultures confirmed an infection, but before resolution of infection (defined by negative blood cultures). A student’s t-test was used for analyses. Results - The study population was heterogeneous in terms of sex (67.5% male) and race (70% Caucasian, 25% African American, and 5% Asian), with an average age of 51±20 years, and an average BMI of 29.65±7.43 in the contrast group and 27.67±3.16 in the non-contrast group (p=0.37). Following ultrasound, no patients had documented stroke, pulmonary embolism, or systemic blood clot, which physicians could have attributed to a thrombus resulting from dislodging of bacterial vegetation. Overall, blood cultures did not clear faster in patients receiving CEUS compared to those undergoing standard echocardiography, (2.63±2.69 days vs. 1.34 ±1.11 days, p=0.09). CEUS also did not shorten the admission length in patients with IE, (16.9±7.7 days vs. 19.9±12.1 days; p=0.36). Conclusion - Based on this limited sample size, patients who underwent CEUS did not have a different prognosis when compared to patients who received a non-contrast echocardiogram

X-ray Timing of PSR J1852+0040 in Kesteven 79: Evidence of Neutron Stars Weakly Magnetized at Birth

The 105-ms X-ray pulsar J1852+0040 is the central compact object (CCO) in SNR Kes 79. We report a sensitive upper limit on its radio flux density of 12 uJy at 2 GHz using the NRAO GBT. Timing using XMM and Chandra over a 2.4 yr span reveals no significant change in its spin period. The 2 sigma upper limit on the period derivative leads, in the dipole spin-down formalism, to an energy loss rate E-dot < 7e33 ergs/s, surface magnetic field strength B_p < 1.5e11 G, and characteristic age tau_c = P/2P-dot > 8 Myr. This tau_c exceeds the age of the SNR by 3 orders of magnitude, implying that the pulsar was born spinning at its current period. However, the X-ray luminosity of PSR J1852+0040, L(bol) ~ 3e33(d/7.1 kpc)^2 ergs/s is a large fraction of E-dot, which challenges the rotation-powered assumption. Instead, its high blackbody temperature, 0.46+/-0.04 keV, small blackbody radius ~ 0.8 km, and large pulsed fraction, ~ 80%, may be evidence of accretion onto a polar cap, possibly from a fallback disk made of supernova debris. If B_p < 1e10 G, an accretion disk can penetrate the light cylinder and interact with the magnetosphere while resulting torques on the neutron star remain within the observed limits. A weak B-field is also inferred in another CCO, the 424-ms pulsar 1E 1207.4-5209, from its steady spin and soft X-ray absorption lines. We propose this origin of radio-quiet CCOs: the B-field, derived from a turbulent dynamo, is weaker if the NS is formed spinning slowly, which enables it to accrete SN debris. Accretion excludes neutron stars born with both B_p 0.1 s from radio pulsar surveys, where B_p 40 Myr) or recycled pulsars. Finally, such a CCO, if born in SN 1987A, could explain the non-detection of a pulsar there.Comment: 8 pages, 3 figures, to appear in The Astrophysical Journa

Discovery of the Putative Pulsar and Wind Nebula Associated with the TeV Gamma-ray Source HESS J1813-178

We present a Chandra X-ray observation of G12.82-0.02, a shell-like radio supernova remnant coincident with the TeV gamma-ray source HESS J1813-178. We resolve the X-ray emission from the co-located ASCA source into a point source surrounded by structured diffuse emission that fills the interior of the radio shell. The morphology of the diffuse emission strongly resembles that of a pulsar wind nebula. The spectrum of the compact source is well-characterized by a power-law with index Gamma approx 1.3, typical of young and energetic rotation-powered pulsars. For a distance of 4.5 kpc, consistent with the X-ray absorption and an association with the nearby star formation region W33, the 2-10 keV X-ray luminosities of the putative pulsar and nebula are L(PSR) = 3.2E33 ergs/s and L(PWN) = 1.4E34 ergs/s, respectively. Both the flux ratio of L(PWN)/L(PSR) = 4.3 and the total luminosity of this system predict a pulsar spin-down power of Edot > 1E37 ergs/s, placing it within the ten most energetic young pulsars in the Galaxy. A deep search for radio pulsations using the Parkes telescope sets an upper-limit of approx 0.07 mJy at 1.4 GHz for periods >~ 50 ms. We discuss the energetics of this source, and consider briefly the proximity of bright H2 regions to this and several other HESS sources, which may produce their TeV emission via inverse Compton scattering.Comment: 7 pages, 6 figure, Latex, emulateapj style. To appear in the Astrophysical Journa

VLBA measurement of the transverse velocity of the magnetar XTE J1810-197

We have obtained observations of the magnetar XTE J1810-197 with the Very Long Baseline Array at two epochs separated by 106 days, at wavelengths of 6 cm and 3.6 cm. Comparison of the positions yields a proper motion value of 13.5+-1.0 mas/yr at an equatorial position angle of 209.4+-2.4 deg (east of north). This value is consistent with a lower-significance proper motion value derived from infrared observations of the source over the past three years, also reported here. Given its distance of 3.5+-0.5 kpc, the implied transverse velocity corrected to the local standard of rest is 212+-35 km/s (1 sigma). The measured velocity is slightly below the average for normal young neutron stars, indicating that the mechanism(s) of magnetar birth need not lead to high neutron star velocities. We also use Australia Telescope Compact Array, Very Large Array, and these VLBA observations to set limits on any diffuse emission associated with the source on a variety of spatial scales, concluding that the radio emission from XTE J1810-197 is >96% pulsed.Comment: Accepted for publication in The Astrophysical Journal. Six pages, 2 figure

PSR J2229+6114: Discovery of an Energetic Young Pulsar in the Error Box of the EGRET Source 3EG J2227+6122

We report the detection of radio and X-ray pulsations at a period of 51.6 ms from the X-ray source RX/AX J2229.0+6114 in the error box of the EGRET source 3EG J2227+6122. An ephemeris derived from a single ASCA observation and multiple epochs at 1412 MHz from Jodrell Bank indicates steady spin-down with P-dot = 7.83 x 10^(-14) s/s. From the measured P and P-dot we derive spin-down power E-dot = 2.2 x 10^(37) erg/s, magnetic field B = 2.0 x 10^(12) G, and characteristic age P/2P-dot = 10,460 yr. An image from the Chandra X-ray Observatory reveals a point source surrounded by centrally peaked diffuse emission that is contained within an incomplete radio shell. We assign the name G106.6+2.9 to this new supernova remnant, which is evidently a pulsar wind nebula. For a distance of 3 kpc estimated from X-ray absorption, the ratio of X-ray luminosity to spin-down power is ~8 x 10^(-5), smaller than that of most pulsars, but similar to the Vela pulsar. If PSR J2229+6114 is the counterpart of 3EG J2227+6122 then its efficiency of gamma-ray production, if isotropic, is 0.016 (d/3 kpc)^2. It obeys an established trend of gamma-ray efficiency among known gamma-ray pulsars which, in combination with the demonstrated absence of any other plausible counterpart for 3EG J2227+6122, makes the identification compelling. If confirmed, this identification bolsters the pulsar model for unidentified Galactic EGRET sources.Comment: 5 pages, 4 figures, accepted by The Astrophysical Journal Letter

The Next Geminga: Deep Multiwavelength Observations of a Neutron Star Identified with 3EG J1835+5918

We describe Chandra, HST, and radio observations that reveal a radio-quiet but magnetospherically active neutron star in the error circle of the high-energy gamma-ray source 3EG J1835+5918, the brightest of the unidentified EGRET sources at high Galactic latitude. A Chandra ACIS-S spectrum of the ultrasoft X-ray source RX J1836.2+5925, suggested by Mirabal & Halpern as the neutron star counterpart of 3EG J1835+5918, requires two components: a blackbody of T~3x10^5 K and a hard tail that can be parameterized as a power law of photon index Gamma~2. An upper limit of d < 800 pc can be derived from the blackbody fit under an assumption of R = 10 km. Deep optical imaging with the HST STIS CCD failed to detect this source to a limit of V > 28.5, thus f_X/f_V > 6000 and d > 250 pc assuming the X-ray fitted temperature for the full surface. Repeated observations with the 76 m Lovell telescope at Jodrell Bank place an upper limit of < 0.1 mJy on the flux density at 1400 MHz for a pulsar with P > 0.1 s, and < 0.25 mJy for a ~10 ms pulsar at the location of RX J1836.2+5925. All of this evidence points to an older, possibly more distant version of the highly efficient gamma-ray pulsar Geminga, as the origin of the gamma-rays from 3EG J1835+5918.Comment: 4 pages, 4 figures, accepted for publication in ApJ Letter

Instantons on Quivers and Orientifolds

We compute the prepotential for gauge theories descending from ${\cal N}=4$ SYM via quiver projections and mass deformations. This accounts for gauge theories with product gauge groups and bifundamental matter. The case of massive orientifold gauge theories with gauge group SO/Sp is also described. In the case with no gravitational corrections the results are shown to be in agreement with Seiberg-Witten analysis and previous results in the literature.Comment: 28 pages, revised version, references added, some typos correcte

The Vela Pulsar and its Synchrotron Nebula

(Abridged) We present high-resolution Chandra X-ray observations of PSR B0833-45, the 89 ms pulsar associated with the Vela supernova remnant. We have acquired two observations separated by one month to search for changes in the pulsar and its environment following an extreme glitch in its rotation frequency. We find a well-resolved nebula with a toroidal morphology remarkably similar to that observed in the Crab Nebula, along with an axial Crab-like jet. Between the two observations the flux from the pulsar is found to be steady to within 0.75%; the 3 sigma limit on the fractional increase in the pulsar's X-ray flux is < ~10^-5 of the inferred glitch energy. We use this limit to constrain parameters of glitch models and neutron star structure. We do find a significant increase in the flux of the nebula's outer arc; if associated with the glitch, the inferred propagation velocity is > 0.7c, similar to that seen in the brightening of the Crab Nebula wisps. We propose an explanation for the X-ray structure of the Vela synchrotron nebula based on a model originally developed for the Crab Nebula. In a departure from the Crab model, the magnetization parameter "sigma" of the Vela pulsar wind is allowed to be of order unity; this is consistent with the simplest MHD transport of magnetic field from the pulsar to the nebula, where B < 4 X 10^-4 G. We review effects that may enhance the probability of alignment between the spin axis and space velocity of a pulsar, and speculate that short-period, slowly moving pulsars are just the ones best-suited to producing synchrotron nebulae with such aligned structures.Comment: 16 pages with 8 figures, uses LaTex, emulateapj.sty. Refereed version. To appear in The Astrophysical Journa

Imaging X-ray, Optical, and Infrared Observations of the Transient Anomalous X-ray Pulsar XTE J1810-197

We report X-ray imaging, timing, and spectral studies of XTE J1810-197, a 5.54s pulsar discovered by Ibrahim et al. (2003) in recent RXTE observations. In a set of short exposures with the Chandra HRC camera we detect a strongly modulated signal (55+/-4% pulsed fraction) with the expected period located at (J2000) 18:09:51.08, -19:43:51.7, with a uncertainty radius of 0.6 arcsec (90% C.L.). Spectra obtained with XMM-Newton are well fitted by a two-component model that typically describes anomalous X-ray pulsars (AXPs), an absorbed blackbody plus power law with parameters kT = 0.67+/-0.01 keV, Gamma=3.7+/-0.2, N_H=(1.05+/-0.05)E22 cm^-2, and Fx(0.5-10 keV) = 3.98E-11 ergs/cm2/s. Alternatively, a 2T blackbody fit is just as acceptable. The location of CXOU J180951.1-194351 is consistent with a point source seen in archival Einstein, Rosat, & ASCA images, when its flux was nearly two orders-of-magnitude fainter, and from which no pulsations are found. The spectrum changed dramatically between the "quiescent" and "active" states, the former can be modeled as a softer blackbody. Using XMM timing data, we place an upper limit of 0.03 lt-s on any orbital motion in the period range 10m-8hr. Optical and infrared images obtained on the SMARTS 1.3m telescope at CTIO show no object in the Chandra error circle to limits V=22.5, I=21.3, J=18.9, & K=17.5. Together, these results argue that CXOU J180951.1-194351 is an isolated neutron star, one most similar to the transient AXP AX J1844.8-0256. Continuing study of XTE J1810-197 in various states of luminosity is important for understanding and possibly unifying a growing class of isolated, young neutron stars that are not powered by rotation.Comment: 12 pages, 7 figures, AAS LaTex, uses emulateapj5.sty. Updated to include additional archival data and a new HRC observation. To appear in The Astrophysical Journa