Evaluation of antiplasmodial effects of the ethanolic leaf extract of Salacia lehmbachii on Plasmodium berghei infected mice

Salacia lehmbachii leaves are used in Nigerian traditional medicine for the treatment of malaria and other diseases. The ethanolic extract was tested for its activities against suppressive, prophylactic and established infections in Plasmodium berghei infected albino mice at dose levels of 100, 200 and 400 mg/kg; while chloroquine (10 mg/kg) was used as positive control. The extract exhibited significant dose-related antiplasmodial activities on parasites with the used-dose levels, showing significant mean survival time. The results, therefore, co-relate with claims by traditional users for the treatment of malaria and other feverish conditions; and could serve as source of potential new antimalarial  agents. DOI: http://dx.doi.org/10.5281/zenodo.55610

EFFICACY OF PHENYTOIN SODIUM IN THE MANAGEMENT OF POST OPERATIVE PAIN

Postoperative pain in three groups of Nigerian patients, comprising 15 cases each of minor, intermediate and major surgical operations, was treated with phenytoin sodium, dihydrocodeine and paracetamol respectively. The aim of the study was to determine the efficacy of phenytoin sodium as a postoperative analgesic agent. Analgesia was assessed using the results of verbal rating scale scores namely, PID (pain intensity difference), SPID (sum of pain intensity difference) and TOTPAR (total pain relief) and a modified global rating scale. The results showed phenytoin sodium to be superior to paracetamol in the treatment of all grades of postoperative pain. It was equipotent to dihydrocodeine in mild and moderate pain, while dihydrocodeine was superior in severe pain. It is concluded that Phenytoin sodium is an efficacious analgesic agent in mild to moderate postoperative pain

Urethral prolapse: A case report and commentrary on management

Urethral prolapse is a relatively uncommon condition manifesting itself as a circumferential protrusion of the distal urethra through the external urethral meatus. The exact etiology remains unknown. It is diagnosed at examination under anesthesia and may be complicated by strangulation. Treatment ranges from conservative to surgical approaches. Herein we present the case of a pre-pubertal girl with a strangulated prolapse, to our knowledge the first case of urethral prolapse reported in Nigeria. Le prolapsus urétral est relativement rare se manifestant comme une protrusion circulaire de l'urètre distal par le méat urétral externe. L'étiologie exacte demeure inconnue. On diagnostique le prolapsus urétral à l'examen sous l'anesthésie et il peut être compliqué d'étranglement. Le traitement est conservateur ou chirurgical. Nous présentons le cas d'une fille pré-pubère avec un prolapsus étranglé, à notre connaissance il s'agit du premier cas de prolapsus urétral enregistré au Nigéria African Journal of Urology Vol. 13 (1) 2007: pp. 50-5

Evaluation of antiplasmodial effects of the ethanolic leaf extract of Salacia lehmbachii on Plasmodium berghei infected mice

Salacia lehmbachii leaves are used in Nigerian traditional medicine for the treatment of malaria and other diseases. The ethanolic extract was tested for its activities against suppressive, prophylactic and established infections in Plasmodium berghei infected albino mice at dose levels of 100, 200 and 400 mg/kg; while chloroquine (10 mg/kg) was used as positive control. The extract exhibited significant dose-related antiplasmodial activities on parasites with the used-dose levels, showing significant mean survival time. The results, therefore, co-relate with claims by traditional users for the treatment of malaria and other feverish conditions; and could serve as source of potential new antimalarial  agents. DOI: http://dx.doi.org/10.5281/zenodo.55610