The effect of hydroalcoholic extracts of Zizipus vulgaris L. on burn healing

زمینه و هدف: از قدیم میوه عناب جهت ترمیم زخم سوختگی مورد استفاده قرار می گرفته است ولی این امر از نظر علمی مورد بررسی قرار نگرفته است. این مطالعه به منظور بررسی اثرات عصاره ی میوه ی عناب بر فرآیند التیام زخم سوختگی در موش Balb/c انجام شده است. روش بررسی: این مطالعه تجربی بر روی 40 سر موش Balb/c به وزن تقریبی 3±30 گرم انجام شد. پس از ایجاد زخم های سوختگی به مساحت 5/1سانتیمتر مربع و تایید سوختگی درجه دو موش ها در چهار گروه کنترل، تحت درمان با وازلین و تحت درمان با عصاره های 1 و 10 عناب تقسیم شدند. در گروه های تحت درمان، 1 گرم پماد روزی 2 بار، تا التیام کامل استعمال شد. سپس چهار گروه از نظر مساحت زخم و وضعیت هیستوپاتولوژی مقایسه شدند. یافته ها: بر اساس آزمون کروسکال والیس تفاوت معنی داری بین درصد بهبودی زخم در 4 گروه وجود داشت (001/0

Ulcerative Keratitis in Gastrointestinal Stromal Tumor Patients Treated with Perifosine

Perifosine is a novel alkylphospholipid with antiproliferative properties attributed to protein kinase B inhibition. The authors describe a form of ulcerative keratitis in 5 patients with advanced gastrointestinal stromal tumor (GIST) enrolled in a phase I/II trial of perifosine in combination with imatinib. Interventional case series. Five patients (1 man, 4 women) with imatinib-resistant metastatic GIST who received a combination of imatinib and perifosine orally. The medical records were reviewed retrospectively. Ocular toxicity and ulcerative keratitis associated with perifosine. The ocular symptoms included redness, irritation, tearing, photophobia, and a gradual decrease in vision. Slit-lamp biomicroscopy in each case revealed a peripheral, paralimbal, ring-shaped, superficial corneal stromal infiltration and ulcerative keratitis, reminiscent of the autoimmune keratitis in conditions such as rheumatoid arthritis. The ulcerative keratitis was unilateral in 3 and bilateral in 2 patients; it was National Cancer Institute grade II (symptoms interfering with function but not interfering with activities of daily living) in all patients. All 5 patients had imatinib-resistant metastatic GIST and had continued on the highest dose of imatinib tolerated and initiated therapy with perifosine 100 mg daily or 900 mg weekly. A combination of topical steroids, topical antibiotics, and lubricating drops were used to manage ulcerative keratitis. In the first 3 patients, ulcerative keratitis initially was treated with topical antibiotics without improvement, but subsequently they improved significantly after topical steroids were added. A vision-threatening form of ulcerative keratitis may occur in patients taking perifosine. It is possible that imatinib in combination with perifosine contributes to this corneal toxicity; however, the authors are unaware of this ocular toxicity having been reported for imatinib when used without perifosine. The visual loss associated with perifosine may be reversible if detected and treated early and with judicious early use of topical steroids, topical antibiotic coverage, and lubrication