Patient characteristics and surgery-related factors associated with patient-reported recovery at 1 and 6 months after colorectal cancer surgery

Predictors for postoperative recovery after colorectal cancer surgery are usually investigated in relation to length of stay (LoS), readmission, or 30-day morbidity. This study describes patient characteristics and surgery-related factors associated with patient-reported recovery 1 and 6 months after surgery. In total, 153 consecutively included patients who were recovering from colorectal cancer surgery reported their level of recovery using the Postoperative Recovery Profile. Multiple logistic regression analysis was used to calculate associations with recovery, defined as good or poor, divided into five recovery dimensions: physical symptoms, physical functions, psychological, social and activity. Better preoperative health predicted good recovery regarding three dimensions 1 month after surgery. Regarding all dimensions 1 month after surgery, poor recovery was predicted by a poor recovery on the day of discharge within corresponding dimensions. Higher age was associated with good recovery 6 months after surgery, while chemotherapy showed negative associations. Overall, a majority of factors had a negative impact on recovery, but without any obvious relation to one specific dimension or point in time. Those factors were: high Body Mass Index, comorbidity, abdominoperineal resection, loop ileostomy, colostomy and LoS. This study illustrates the complexity of postoperative recovery and a need for individualised follow-up strategies

Synthesis and Structural Characterization of Hydrolysis Products within the Uranyl Iminodiacetate and Malate Systems

The interplay of hydrolysis and chelation by organic ligands results in the formation of novel uranium species in aqueous solutions. Many of these molecular complexes have been identified by spectroscopic and potentiometric techniques, but a detailed structural understanding of these species is lacking. Identification of possible uranyl hydrolysis products in the presence of organic functional groups has been achieved by the crystallization of molecular species into a solid-state compound, followed by structural and chemical characterization of the material. The structures of three novel molecular complexes containing either iminodiacetate (<i>ida</i>) (Na₃[(UO₂)₃(OH)₃(ida)₃]·8H₂O (<b>1</b>)) or malate (<i>mal</i>) (K­(<i>pip</i>)₂[(UO₂)₃O­(<i>mal</i>)₃]·6H₂O (<b>2a</b>) (<i>pip</i> = C₄N₂H₁₂), (<b>2b</b>) (<i>pip</i>)₃[(UO₂)₃O­(<i>mal</i>)₃]·H₂O, and (<i>pip</i>)₆[(UO₂)₁₁(O)₄(OH)₄(<i>mal</i>)₆(CO₃)₂]·23H₂O (<b>3</b>)) ligands have been determined by single-crystal X-ray diffraction and have been chemically characterized by IR, Raman, and NMR spectroscopies. A major structural component in compounds <b>1</b> and <b>2</b> is a trimeric 3:3 uranyl <i>ida</i> or <i>mal</i> species, but different bridging groups between the metal centers create variations in the structural topologies of the molecular units. Compound <b>3</b> contains a large polynuclear cluster with 11 U atoms, which is composed of trimeric and pentameric building units chelated by <i>mal</i> ligands and linked through hydroxyl groups and carbonate anions. The characterized compounds represent novel structural topologies for U⁶⁺ hydrolysis products that may be important molecular species in near-neutral aqueous systems

Synthesis and Structural Characterization of Hydrolysis Products within the Uranyl Iminodiacetate and Malate Systems

The interplay of hydrolysis and chelation by organic ligands results in the formation of novel uranium species in aqueous solutions. Many of these molecular complexes have been identified by spectroscopic and potentiometric techniques, but a detailed structural understanding of these species is lacking. Identification of possible uranyl hydrolysis products in the presence of organic functional groups has been achieved by the crystallization of molecular species into a solid-state compound, followed by structural and chemical characterization of the material. The structures of three novel molecular complexes containing either iminodiacetate (<i>ida</i>) (Na₃[(UO₂)₃(OH)₃(ida)₃]·8H₂O (<b>1</b>)) or malate (<i>mal</i>) (K­(<i>pip</i>)₂[(UO₂)₃O­(<i>mal</i>)₃]·6H₂O (<b>2a</b>) (<i>pip</i> = C₄N₂H₁₂), (<b>2b</b>) (<i>pip</i>)₃[(UO₂)₃O­(<i>mal</i>)₃]·H₂O, and (<i>pip</i>)₆[(UO₂)₁₁(O)₄(OH)₄(<i>mal</i>)₆(CO₃)₂]·23H₂O (<b>3</b>)) ligands have been determined by single-crystal X-ray diffraction and have been chemically characterized by IR, Raman, and NMR spectroscopies. A major structural component in compounds <b>1</b> and <b>2</b> is a trimeric 3:3 uranyl <i>ida</i> or <i>mal</i> species, but different bridging groups between the metal centers create variations in the structural topologies of the molecular units. Compound <b>3</b> contains a large polynuclear cluster with 11 U atoms, which is composed of trimeric and pentameric building units chelated by <i>mal</i> ligands and linked through hydroxyl groups and carbonate anions. The characterized compounds represent novel structural topologies for U⁶⁺ hydrolysis products that may be important molecular species in near-neutral aqueous systems