Predictive value of MRI-detected tumor deposits in locally advanced rectal cancer

BackgroundAlthough tumor deposits (TDs) are not the same as lymph nodes, the prognosis of patients with TDs is similar or worse than that of patients with metastatic lymph nodes. TDs are mostly assessed by the histology of samples after surgery, thus, not helpful for preoperative treatment strategies. The primary objective of this study was to detect TDs by MRI and evaluate its predictive value.Materials and methodsA total of 114 patients with rectal cancer were retrospectively analyzed. Clinicopathological and MRI data mainly including MRI- detected TDs (mTDs), tumor border configuration (TBC) on MRI, MRI-detected extramural vascular invasion (mEMVI), MRI-detected lymph node metastasis (mLN), MRI T stage, MRI N stage, the range of rectal wall involved by the tumor, peritoneal reflection invasion, tumor length, tumor location, cord sign at the tumor edge, nodular protrusion at the tumor edge, maximal extramural depth and pathology-proven lymph node involvement (pLN) were evaluated. The correlation of MRI factors with postoperative distant metastasis (PDM) and pLN were analyzed by univariate analysis and multivariate logistic regression analysis, and nomograms were established based on the latter. The diagnostic efficiency was evaluated by the receiver operating characteristic curve (ROC) and area under the curve (AUC).ResultsA total of 38 cases of pLN, 13 of PDM and 17 of pathology-proven TDs (pTDs) were found. Ten cases of PDM and 22 cases of pLN in 30 mTDs cases were also found. Chi-square test showed that mTDs, mLN, TBC, mEMVI, MRI T stage, nodular protrusion, cord sign, maximal extramural depth and peritoneal reflection invasion were correlated with PDM and pLN (P<0.05). mTDs and peritoneal reflection invasion were independent risk factors for PDM (odds ratio: 10.15 and 8.77, P<0.05), mTDs and mLN were independent risk factors for pLN (odds ratio: 5.50 and 5.91, P<0.05), and Hosmer-Lemeshow test showed that the results of two models were not statistically significant, suggesting that the fit was good. On this basis, two nomograms for predicting PDM and pLN were confirmed by Bootstrap self-sampling, and the C-indices of the two nomograms were 0.837 and 0.817, respectively. The calibration curves and ROC curves of the two nomograms showed that the correlation between the predicted and the actual incidence of PDM and pLN was good. The DeLong test showed that the predictive efficiency of the nomogram in predicting pLN was better than that of mLN (P=0.0129).ConclusionmTDs are a risk factor for PDM and lymph node metastasis. The two nomograms based on mTDs showed a good performance in predicting PDM and lymph node metastasis, possessing a certain clinical value

Mars Cruise Orbit Determination from Combined Optical Celestial Techniques and X-ray Pulsars

WOS: 000402822000004The precise autonomous navigation for deep space exploration by combination of multi-source observation data is a key issue for probe control and scientific applications. In this paper, the performance of an integrated Optical Celestial Navigation (OCN) and X-ray Pulsars Autonomous Navigation (XNAV) system is investigated for the orbit of Mars Pathfinder. Firstly, OCN and XNAV single systems are realised by an Unscented Kalman Filter (UKF). Secondly, the integrated system is simulated with a Federated Kalman Filter (FKF), which can do the information fusion of the two subsystems of UKF and inherits the advantages of each subsystem. Thirdly, the performance of our system is evaluated by analysing the relationship between observation errors and navigation accuracy. The results of the simulation experiments show that the biases between the nominal and our calculated orbit are within 5 km in all three axes under complex error conditions. This accuracy is also better than current ground-based techniques.National Keystone Basic Research Program (MOST 973) [2012CB72000]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [41374012, 11173050, 11373059]; Shanghai Science and Technology Commission Project [12DZ2273300]This work was supported by the National Keystone Basic Research Program (MOST 973) (Grant no. 2012CB72000), National Natural Science Foundation of China (No. 41374012, 11173050 and 11373059), and Shanghai Science and Technology Commission Project (No. 12DZ2273300)

Effect of lunar gravity models on Chang'E-2 orbit determination using VLBI tracking data

The precise orbit determination of Chang'E-2 is the most important issue for successful mission and scientific applications, while the lunar gravity field model with big uncertainties has large effect on Chang'E-2 orbit determination. Recently, several new gravity models have been produced using the latest lunar satellites tracking data, such as LP165P, SGM150J, GL0900D and GRGM900C. In this paper, the four gravity models mentioned above were evaluated through the power spectra analysis, admittance and coherence analysis. Effect of four lunar gravity models on Chang'E-2 orbit determination performance is investigated and assessed using Very Long Baseline Interferometry (VLBI) tracking data. The overlap orbit analysis, the posteriori data residual, and the orbit prediction are used to evaluate the orbit precision between successive arcs. The LP165P model has better orbit overlap performance than the SGM150J model for Chang'E-2100 km × 100 km orbit and the SGM150J model performs better for Chang'E-2100 km × 15 km orbit, while GL0900D and GRGM900C have the best orbit overlap results for the two types of Chang'E-2 orbit. For the orbit prediction, GRGM900C has the best orbit prediction performance in the four models