The <i>A</i>_<i>570</i> values of every PS₇-sPS₃ group.

<p>^a-f Column date without the same superscripts differ significantly (<i>P</i> <0.05). Values are mean ± S.D, <i>n</i> = 4/group.</p><p>The <i>A</i>_<i>570</i> values of every PS₇-sPS₃ group.</p

The highest virus inhibitory rates in all prescription groups.

<p>^a-h Bars marked without the same letters differ significantly (<i>P</i> <0.05).</p

The <i>A</i>₅₇₀ values of every PS₆-sPS₄ group.

<p>^a-d Column date without the same superscripts differ significantly (<i>P</i> <0.05). Values are mean ± S.D, <i>n</i> = 4/group.</p><p>The <i>A</i>₅₇₀ values of every PS₆-sPS₄ group.</p

The <i>A</i>₅₇₀ values of every PS₉-sPS₁ group.

<p>^a-f Column date without the same superscripts differ significantly (<i>P</i> <0.05). Values are mean ± S.D, <i>n</i> = 4/group.</p><p>The <i>A</i>₅₇₀ values of every PS₉-sPS₁ group.</p

The morbidity, mortality and cure rate in every group.

<p>^a-b Bars in the same index marked without the same letters differ significantly (<i>P</i> <0.05).</p

The changes of fluorescence in every group.

<p>A) Virus control group. B) Experimental group. C) Cell control group.</p

Additional file 3 of MHC class I links with severe pathogenicity in C57BL/6N mice infected with SARS-CoV-2/BMA8

Additional file 3 The sequence of Ace2 gene of BALB/c mice

The FT-IR spectra of SP, CP and sCP.

<p>The FT-IR spectra of SP, CP and sCP.</p

The changes of NDV structure in every group.

<p>A) Virus control group. B) Experimental group after incubation of 30 min. C) Experimental group after incubation of 60 min. D) Experimental group after incubation of 120 min.</p

Additional file 1 of MHC class I links with severe pathogenicity in C57BL/6N mice infected with SARS-CoV-2/BMA8

Additional file 1 TableS1. The list of RT-qPCR primers used in this study. Fig.S1Acquisition of SARS-CoV-2 mouse-adapted strain BMA8. Fig.S2The effects of BMA8 strain on pathogenicity of infected mice. Fig.S3 The NP expression in lung tissues of infected mice. Fig. S4 The effects of BMA8 strain infection on the expression of inflammation-related genes in lung tissues of C57BL/6N and BALB/c mice at 0 dpi and 3 dpi, including Ifnb1, Cxcl10, Ccl2, Il6, Tnf, Ifit3, Irf7, Gbp5 and Isg15.Fig. S5 The expression levels of ACE2 protein in lung and kidney tissues of C57BL/6N and BALB/c mice; β-actin was used as a loading control. Fig. S6 Effects of H-2Kb mAbs on body weight and survival rate of mice infected with BMA8 strain. Fig. S7 Effects of H-2Kb mAbs on pathogenicity of BMA8 strain in C57BL/6N mice. Fig. S8 The expression of NP in lung tissues of infected mice. Fig. S9 The effects of BMA8 strain infection on the expression of inflammation-related genes in lung tissues of C57BL/6N and BALB/c mice with or without H-2Kb mAbs treatment, including Ifnb1, Cxcl9, Cxcl10, Ccl2, Ccl3, Ccl5, Il6, Tnf, Ifit3, Mx1 and Irf7