The Successful Relaunch of Scientia Pharmaceutica Continues Achieving Success

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Preparation of clinical-grade recombinant canarypox-human immunodeficiency virus vaccine-loaded human dendritic cells

Preclinical data are reported that support a human immunodeficiency virus (HIV) vaccine strategy using recombinant canarypox-HIV vectors (ALVAC-HIV) to load human dendritic cells (DCs) with HIV antigens. Clinical-grade DCs were infected with good manufacturing practice-grade ALVAC-HIV vaccine constructs. ALVAC infection, HIV gene expression, and DC viability and function were monitored by use of immunohistochemistry, flow cytometry, blastogenesis assays, antigen-specific interferon (IFN)-γ enzyme-linked immunospot assay, and enzyme-linked immunosorbent assay protein detection. The vaccines infected both immature and mature DCs, and intracellular HIV-1 Gag protein was detected within hours. ALVAC-HIV induced DC maturation that was mediated by tumor necrosis factor-α and induced DC apoptosis that was directly related to the length of vaccine exposure. Of importance, the infected DCs remained functional in T cell stimulation assays and induced HIV antigen-specific CD8+ T cell production of IFN-γ from cells of HIV-1-infected individuals. These data support an ongoing HIV vaccine trial comparing conventional vaccine delivery routes with ex vivo vaccine-loaded autologous DCs for immunogenicity in HIV-1-uninfected volunteers

Sonoluminescing air bubbles rectify argon

The dynamics of single bubble sonoluminescence (SBSL) strongly depends on the percentage of inert gas within the bubble. We propose a theory for this dependence, based on a combination of principles from sonochemistry and hydrodynamic stability. The nitrogen and oxygen dissociation and subsequent reaction to water soluble gases implies that strongly forced air bubbles eventually consist of pure argon. Thus it is the partial argon (or any other inert gas) pressure which is relevant for stability. The theory provides quantitative explanations for many aspects of SBSL.Comment: 4 page

Discovering neutrinoless double-beta decay in the era of precision neutrino cosmology

We evaluate the discovery probability of a combined analysis of proposed neutrinoless double-beta decay experiments in a scenario with normal ordered neutrino masses. The discovery probability strongly depends on the value of the lightest neutrino mass, ranging from zero in case of vanishing masses and up to 80-90% for values just below the current constraints. We study the discovery probability in different scenarios, focusing on the exciting prospect in which cosmological surveys will measure the sum of neutrino masses. Uncertainties in nuclear matrix element calculations partially compensate each other when data from different isotopes are available. Although a discovery is not granted, the theoretical motivations for these searches and the presence of scenarios with high-discovery probability strongly motivates the proposed international, multi-isotope experimental program

Banksy Got Back? Problems with Chains of Unauthorized Derivative Works and Arrangements in Cover Songs Under a Compulsory License

This Article will analyze the scope of copyright ownership in relation to chains of unauthorized derivative works and chains of arrangement rights in cover versions of musical recordings. In particular, the analysis will focus on the gray area in the law where an unauthorized derivative work (“D1”) is created by an author and another author creates a second derivative work (“D2”) based off of D1. In situations such as these, does the creator of the original derivative work have any rights in their creation if their derivative work was unauthorized? Further, depending on what rights do exist for D1, can the creator of the D2 be found to be infringing upon D1? Moreover, even in the case of certain authorized chains of works such as musical “covers” produced under a compulsory license, does the creator of the first derivative work D1 have any legal recourse against further authorized derivative work creators who base their work on the first derivative work? This phenomenon is demonstrated through examples based in contemporary urban art (Keith Haring and Banksy) and cover songs created through compulsory licenses (Sir Mix-A-Lot, Glee, and Jonathan Coulton)

U(2) Is Right for Leptons and Left for Quarks.

We posit that the distinct patterns observed in fermion masses and mixings are due to a minimally broken U(2)_{q+e} flavor symmetry acting on left-handed quarks and right-handed charged leptons, giving rise to an accidental U(2)^{5} symmetry at the renormalizable level without imposing selection rules on the Weinberg operator. We show that the symmetry can be consistently gauged by explicit examples and comment on realizations in SU(5) unification. Via a model-independent analysis of a standard model viewed as an effective field theory, we find that selection rules due to U(2)_{q+e} enhance the importance of charged lepton flavor violation as a probe, where significant experimental progress is expected in the near future