BLACK SEA: MODERN TECHNOLOGIES USED TO REDUCE COSTS IN ACCOMMODATION SPACES FROM SUSTAINABLE DEVELOPMENT PERSPECTIVE

The size of modern tourism becomes increasingly important; a particular problem facing the tourism industry is providing for tourists higher-quality services. For a customer to return the same hotel, you need equipment and qualified personnel. This paper aims to present modern technologies with which, in hospitality industry, can provide quality services at lower costs, considering the environment protection.hotel industry, emerging technologies, costs, sustainable development

IS EVA AN IMPORTANT FORECASTING TOOL FOR KNOWLEDGEBASED ORGANIZATIONS IN ECONOMIC CRISES TIME?

Nowadays we may observe that all the economies are passing through financial and economic crisis. How can move from high economic growth in the crisis? Here is a question that sits on many lips. In European Union recession is spreading, not to mention the U.S., where the financial crisis is feeling more acute.forecasting, economic value added, cash flow

THE EVOLUTION OF SNP PETROM STOCK LIST - STUDY THROUGH AUTOREGRESSIVE MODELS

Stock exchange market is one of the most dynamic and unpredictable markets. In this context, this work intends to analyze the SNP Petrom shares on the REGS market, based on the chronological series. The economic series are often not stationary, but they can be stationarized by different data transformations. The simplest method used for stationarizing a series is to apply differentiating operators of various classes on the series. After applying this operator, a stationary series that can be modified by an ARIMA (p.q) process is usually obtained. Most time series with economic content include a seasonal component besides the trend and random component. The purpose of this work is to estimate the parameters of an ARIMA (p,d,q) model for SNP Petrom shares, where p is the number of autoregressive terms, d is the integration level of the series (how many times the series must be differentiated in order to become stationary) and q is the number of moving average terms (MA).list, economic series, autoregressive models

Italian Guidelines in diagnosis and treatment of alopecia areata

Alopecia areata (AA) is an organ-specific autoimmune disorder that targets anagen phase hair follicles. The course is unpredictable and current available treatments have variable efficacy. Nowadays, there is relatively little evidence on treatment of AA from well-designed clinical trials. Moreover, none of the treatments or devices commonly used to treat AA are specifically approved by the Food and Drug Administration. The Italian Study Group for Cutaneous Annexial Disease of the Italian Society of dermatology proposes these Italian guidelines for diagnosis and treatment of Alopecia Areata deeming useful for the daily management of the disease. This article summarizes evidence-based treatment associated with expert-based recommendations

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection

Analysis of Main Economic Factors Influence on Romanian Tourists Number Accommodated in Romania, using Anova Method

Now, it is indisputable the role, increasingly important, that tourism plays in economic and social development. This is reflected particularly through the tourism movement, which by generating revenue contributes to the creation of GDP. Size of tourist movement can be expressed through the following indicators: number of tourists, the number of check-in for nights, average length of holiday, density of tourist movements, the relative preference for travel, the revenue and the average number of tourists. The aim of this paper is to identify the main influence of economic factors - total income of households and consumer price indices, registered in Romania in the period 2001-2007 -, on the evolution Romanian tourists number accommodated in Romania, using the dispersion analysis method ANOVA

Efficient Actions for Cutting Down the Costs in Tourism Industry Companies in a Crisis Period

A decision making process, deployed on different organisational levels needs to support on data regarding the registered costs and other relevant analysis, derived from the inside of the company, provided by a managerial accountancy that has to answer to the necessity of information required by the company's management. This article exposes several considerations regarding the managerial control importance of costs calculation and accountancy, as well as the directions for cutting down the expenditures in this stage of Romanian economy. How can be achieved a permanent awareness of the management in order to achieve the performance objectives? In practice it is a question to which we receive answers in a more or less ambiguous manner.economic crisis, tourism industry, competition

Diabetes mellitus and periodontal disease

Diabetes mellitus (DM) is a chronic non-transmittable disease and, alongside periodontal disease, another chronic disease, but with infectious and inflammatory etiology, that have increasing prevalence. The link between the two comorbidities is bidirectional, with common aspects such the inflammatory state, altered immune response and healing process. This link is alimented, also, by oxidative stress, an element that can initiate proinflammatory pathways in both pathologies. Moreover, periodontal disease favors the development of DM complications by a multifactorial mechanism centered on hyperglycemia, that leads to damage of the endothelial vascular cells, characteristic for microvascular complications, while the periodontal bacteria and their waste products, and inflammatory cytokines lead to an increase in systemic inflammation and damage of the vascular walls that aggravates the atherogenic process. The increase of novel cases of type 2 DM or gestational DM in patients with periodontitis has no sufficient data. Dental caries is favored by DM and not by periodontal disease. So, DM is a well-known risk factor for periodontal disease and, on the other hand, periodontitis influences the metabolic control and favors the development of DM complications, but with a link between these conditions that is not fully understood. Other comorbidities, such as missing teeth, depression, osteoporosis are, also, positively associated to higher risk of development for periodontal disease. Patients with DM should be regularly screened for periodontal disease and referred to therapy if necessary, while the patients with periodontal disease should be screened for the presence of DM

In Vivo Assessment of Hepatic and Kidney Toxicity Induced by Silicon Quantum Dots in Mice

In the last decade, silicon-based quantum dots (SiQDs) have attracted the attention of researchers due to their unique properties for which they are used in medical applications and in vivo imaging. Detection of cytotoxic effects in vivo is essential for understanding the mechanisms of toxicity, a mandatory step before their administration to human subjects. In this context, we aimed to evaluate the in vivo hepatic and renal acute toxicity of SiQDs obtained by laser ablation. The nanoparticles were administrated at different doses (0, 1, 10, and 100 mg of QDs/kg of body weight) by intravenous injection into the caudal vein of Swiss mice. After 1, 6, 24, and 72 h, the animals were euthanatized, and liver and kidney tissues were used in further toxicity tests. The time- and dose-dependent effects of SiQDs on the antioxidant defense system of mice liver and kidney were investigated by quantifying the activity of antioxidant enzymes (catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, and glutathione S-transferase) in correlation with the morphological changes and inflammatory status in the liver and kidneys. The results showed a decrease in the activities of antioxidant enzymes and histopathological changes, except for superoxide dismutase, in which no significant changes were registered compared with the control. Furthermore, the immunohistochemical expression of TNF-α was significant at doses over 10 mg of QDs/kg of body weight and were still evident at 72 h after administration. Our results showed that doses under 10 mg of SiQDs/kg of b.w. did not induce hepatic and renal toxicity, providing useful information for further clinical trials

Comprehensive In Vitro Testing of Calcium Phosphate-Based Bioceramics with Orthopedic and Dentistry Applications

Recently, a large spectrum of biomaterials emerged, with emphasis on various pure, blended, or doped calcium phosphates (CaPs). Although basic cytocompatibility testing protocols are referred by International Organization for Standardization (ISO) 10993 (parts 1&ndash;22), rigorous in vitro testing using cutting-edge technologies should be carried out in order to fully understand the behavior of various biomaterials (whether in bulk or low-dimensional object form) and to better gauge their outcome when implanted. In this review, current molecular techniques are assessed for the in-depth characterization of angiogenic potential, osteogenic capability, and the modulation of oxidative stress and inflammation properties of CaPs and their cation- and/or anion-substituted derivatives. Using such techniques, mechanisms of action of these compounds can be deciphered, highlighting the signaling pathway activation, cross-talk, and modulation by microRNA expression, which in turn can safely pave the road toward a better filtering of the truly functional, application-ready innovative therapeutic bioceramic-based solutions