8 research outputs found
Experimental and Clinical Evaluation of Capsular and Parenchymal Total Liver Perfusion
Liver blood flow measurements obtained from both the liver surface and deep within the parenchyma,
were correlated in an effort to assess the usefulness of laser-Doppler flowmetry for non-invasive
monitoring of total liver blood flow, the probe being positioned on either the surface or within the liver
parenchyma
Benefits of a synbiotic formula (Synbiotic 2000Forte (R)) in critically ill trauma patients: Early results of a randomized controlled trial
Background: Since probiotics are considered to exert beneficial health
effects by enhancing the host’s immune response, we investigated the
benefits of a synbiotics treatment on the rate of infections, systemic
inflammatory response syndrome (SIRS), severe sepsis, and mortality in
critically ill, mechanically ventilated, multiple trauma patients.
Length of stay in the intensive care unit (ICU) and number of days under
mechanical ventilation were also evaluated.
Method: Sixty-five patients were randomized to receive once daily for 15
days a synbiotic formula (Synbiotic 2000Forte, Medipharm, Sweden) or
maltodextrin as placebo. The synbiotic preparation consisted of a
combination of four probiotics (10(11) CFU each): Pediococcus
pentosaceus 5-33:3, Leuconostoc mesenteroides 32-77:1, L. paracasei ssp.
paracasei 19; and L. plantarum 2,362; and inulin, oat bran, pectin, and
resistant starch as prebiotics. Infections, septic complications,
mortality, days under ventilatory support, and days of stay in ICU were
recorded.
Results: Synbiotic-treated patients exhibited a significantly reduced
rate of infections (P = 0.01), SIRS, severe sepsis (P = 0.02), and
mortality. Days of stay in the ICU (P = 0.01) and days under mechanical
ventilation were also significantly reduced in relation to placebo (P =
0.001).
Conclusion: The administration of this synbiotic formula in critically
ill, mechanically ventilated, multiple trauma patients seems to exert
beneficial effects in respect to infection and sepsis rates and to
improve the patient’s response, thus reducing the duration of
ventilatory support and intensive care treatment
Serpin Family E Member 1 Tag Single-Nucleotide Polymorphisms in Patients with Diabetic Nephropathy: An Association Study and Meta-Analysis Using a Genetic Model-Free Approach
Background: Many lines of evidence highlight the genetic contribution on the development of diabetic nephropathy (DN). One of the studied genes is SERPINE1 whose the role in the risk of developing DN remains questionable. In order to elucidate the contribution of SERPINE1 in DN progression in the context of type 2 diabetes mellitus (T2DM), we conducted an association study and meta-analysis of SERPINE1 genetic variants. Materials and Methods: A total of 190 patients with DN, 150 T2DM (type 2 diabetes mellitus) patients without DN and 238 healthy controls were recruited. We selected five tag single-nucleotide polymorphisms (SNPs) from the HapMap. The generalized odds ratio (ORG) was calculated to estimate the risk on DN development. Subgroup analyses based on ethnicity and type of diabetes were also performed. Results: Both the present association study regarding SERPINE1 SNPs (rs2227667, rs2070682, rs1050813, rs2227690, rs2227692) did not found any significant association between SERPINE1 variants and DN and the meta-analysis of variant 4G>5G (rs1799889) did not also reveal a significant association between 4G>5G variant and DN in main and subgroup analyses. Discussion: In conclusion, the present association study and meta-analysis provides strong evidence that SERPINE1 genetic variant 4G>5G is not implicated in the risk or development of DN in Caucasians. Further studies in other populations remain to further investigate the role of this variant in the course of DN
Serpin Family E Member 1 Tag Single-Nucleotide Polymorphisms in Patients with Diabetic Nephropathy: An Association Study and Meta-Analysis Using a Genetic Model-Free Approach
Background: Many lines of evidence highlight the genetic contribution on the development of diabetic nephropathy (DN). One of the studied genes is SERPINE1 whose the role in the risk of developing DN remains questionable. In order to elucidate the contribution of SERPINE1 in DN progression in the context of type 2 diabetes mellitus (T2DM), we conducted an association study and meta-analysis of SERPINE1 genetic variants. Materials and Methods: A total of 190 patients with DN, 150 T2DM (type 2 diabetes mellitus) patients without DN and 238 healthy controls were recruited. We selected five tag single-nucleotide polymorphisms (SNPs) from the HapMap. The generalized odds ratio (ORG) was calculated to estimate the risk on DN development. Subgroup analyses based on ethnicity and type of diabetes were also performed. Results: Both the present association study regarding SERPINE1 SNPs (rs2227667, rs2070682, rs1050813, rs2227690, rs2227692) did not found any significant association between SERPINE1 variants and DN and the meta-analysis of variant 4G>5G (rs1799889) did not also reveal a significant association between 4G>5G variant and DN in main and subgroup analyses. Discussion: In conclusion, the present association study and meta-analysis provides strong evidence that SERPINE1 genetic variant 4G>5G is not implicated in the risk or development of DN in Caucasians. Further studies in other populations remain to further investigate the role of this variant in the course of DN