6 research outputs found
Pharmacological properties of ionotropic glutamate receptors expressed in Xenopus oocytes
No full textSIGLEAvailable from British Library Document Supply Centre-DSC:DXN015925 / BLDSC - British Library Document Supply CentreGBUnited Kingdo
Solid phase synthesis and biological evaluation of enantiomerically pure wasp toxin analogues PhTX-343 and PhTX-12
No full textModification of the philanthotoxin-343 polyamine moiety results in different structure-activity profiles at muscle nicotinic ACh, NMDA and AMPA receptors
No full textA single amino acid change makes a rat neuronal sodium channel highly sensitive to pyrethroid insecticides
No full textTwo amino acid substitutions in a housefly sodium channel, L1014F in domain IIS6 and M918T in the IIS4-S5 linker, have been identified in kdr and super-kdr pyrethroid-resistant phenotypes, respectively. Unlike their native insect counterparts, mammalian sodium channels are only weakly sensitive to pyrethroids. Do the sodium channels of mammal and pyrethroid-resistant housefly share similar structural characteristics that account for their low pyrethroid sensitivities? We report here that substitution of isoleucine for methionine at position 874 (equivalent to the super-kdr site 918 in the housefly) in the rat IIa alpha-subunit causes a 100-fold increase in sensitivity. (C) 2000 Federation of European Biochemical Societies
