41 research outputs found
Metallicity Effects on Dust Properties in Starbursting Galaxies
We present infrared observations of 66 starburst galaxies over a wide range
of oxygen abundances, to measure how metallicity affects their dust properties.
The data include imaging and spectroscopy from the Spitzer Space Telescope,
supplemented by groundbased near-infrared imaging. We confirm a strong
correlation of aromatic emission with metallicity, with a threshold at a
metallicity [12+log(O/H)]~8. The large scatter in both the metallicity and
radiation hardness dependence of this behavior implies that it is not due to a
single effect, but to some combination. We show that the far-infrared color
temperature of the large dust grains increases towards lower metallicity,
peaking at a metallicity of 8 before turning over. We compute dust masses and
compare them to HI masses from the literature to derive the gas to dust ratio,
which increases by nearly 3 orders of magnitude between solar metallicity and a
metallicity of 8, below which it flattens out. The abrupt change in aromatic
emission at mid-infrared wavelengths thus appears to be reflected in the
far-infrared properties, indicating that metallicity changes affect the
composition of the full range of dust grain sizes that dominate the infrared
emission. In addition, we find that the ratio L(8 micron)/L(TIR), important for
calibrating 24 micron measurements of high redshift galaxies, increases
slightly as the metallicity decreases from ~solar to ~50% of solar, and then
decreases by an order of magnitude with further decreases in metallicity.
Although the great majority of galaxies show similar patterns of behavior as
described above, there are three exceptions, SBS 0335-052E, Haro 11, and SHOC
391. Their infrared SEDs are dominated energetically by the mid-IR near 24
micron rather than by the 60 - 200 micron region. (Abridged)Comment: 34 pages, 11 figures, accepted to Ap
Frequency, mutual exclusivity and clinical associations of myositis autoantibodies in a combined European cohort of idiopathic inflammatory myopathy patients
Objectives: To determine prevalence and co-existence of myositis specific autoantibodies (MSAs) and myositis
associated autoantibodies (MAAs) and associated clinical characteristics in a large cohort of idiopathic inflammatory myopathy (IIM) patients.
Methods: Adult patients with confirmed IIM recruited to the EuroMyositis registry (n = 1637) from four centres
were investigated for the presence of MSAs/MAAs by radiolabelled-immunoprecipitation, with confirmation of
anti-MDA5 and anti-NXP2 by ELISA. Clinical associations for each autoantibody were calculated for 1483 patients with a single or no known autoantibody by global linear regression modelling.
Results: MSAs/MAAs were found in 61.5% of patients, with 84.7% of autoantibody positive patients having a
sole specificity, and only three cases (0.2%) having more than one MSA. The most frequently detected autoantibody was anti-Jo-1 (18.7%), with a further 21 specificities each found in 0.2–7.9% of patients.
Autoantibodies to Mi-2, SAE, TIF1, NXP2, MDA5, PMScl and the non-Jo-1 tRNA-synthetases were strongly associated (p < 0.001) with cutaneous involvement. Anti-TIF1 and anti-Mi-2 positive patients had an increased
risk of malignancy (OR 4.67 and 2.50 respectively), and anti-SRP patients had a greater likelihood of cardiac
involvement (OR 4.15). Interstitial lung disease was strongly associated with the anti-tRNA synthetases, antiMDA5, and anti-U1RNP/Sm. Overlap disease was strongly associated with anti-PMScl, anti-Ku, anti-U1RNP/Sm
and anti-Ro60. Absence of MSA/MAA was negatively associated with extra-muscular manifestations.
Conclusions: Myositis autoantibodies are present in the majority of patients with IIM and identify distinct clinical
subsets. Furthermore, MSAs are nearly always mutually exclusive endorsing their credentials as valuable disease
biomarkers
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
BACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)