135 research outputs found

    PLASMA CONCENTRATIONS OF METHADONE DURING POSTOPERATIVE PATIENT-CONTROLLED EXTRADURAL ANALGESIA

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    Plasma concentrations of methadone were measured by gas chromatography in 16 patients receiving extradural methadone by continuous infusion for relief of postoperative pain. Venous blood samples were taken after a loading dose of extradural methadone 2 mg and during infusion of 0.46 mg h−1 plus patient-controlled increments of 0.2-1 mg. Mean (SD) plasma concentration of methadone was 9.8 (2.1) ng ml−1 at 15 min; this did not change significantly during the first 2 h, after which it increased gradually to 32.2 (4.6) ng ml−1 (P < 0.001) at the end of 24 h. The mean quantity of extradural methadone required to produce effective analgesia was 10.3 (1.8) mg during the first 12 h after operation and 6 (1.0) mg for the subsequent 12 h. The mean amount of methadone for effective analgesia on the second day was 7.6 (1.1) mg. No adverse effects were detected during the 2-3 days of methadone therapy. Plasma concentration of methadone increased significantly during patient-controlled infusion of extradural methadone in the first 24 h after operation, suggesting rapid vascular uptake. Systemic activity of the drug contributes to the analgesic effect of extradural methadon

    Effective suppression of parametric instabilities with decoupled broadband lasers in plasma

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    A theoretical analysis for the stimulated Raman scattering (SRS) instability driven by two laser beams with certain frequency difference is presented. It is found that strong coupling and enhanced SRS take place only when the unstable regions for each beam are overlapped in the wavenumber space. Hence a threshold of the beam frequency difference for their decoupling is found as a function of their intensity and plasma density. Based upon this, a strategy to suppress the SRS instability with decoupled broadband lasers (DBLs) is proposed. A DBL can be composed of tens or even hundreds of beamlets, where the beamlets are distributed uniformly in a broad spectrum range such as over 10% of the central frequency. Decoupling among the beamlets is found due to the limited beamlet energy and suitable frequency difference between neighboring beamlets. Particle-in-cell simulations demonstrate that SRS can be almost completely suppressed with DBLs under the laser intensity ∼ 1015 W/cm2. Moreover, stimulated Brillouin scattering (SBS) will be suppressed simultaneously with DBLs can be attractive for driving inertial confined fusion

    A 750 mW, continuous-wave, solid-state laser source at 313 nm for cooling and manipulating trapped 9Be+ ions

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    We present a solid-state laser system that generates 750 mW of continuous-wave single-frequency output at 313 nm. Sum-frequency generation with fiber lasers at 1550 nm and 1051 nm produces up to 2 W at 626 nm. This visible light is then converted to UV by cavity-enhanced second-harmonic generation. The laser output can be tuned over a 495 GHz range, which includes the 9Be+ laser cooling and repumping transitions. This is the first report of a narrow-linewidth laser system with sufficient power to perform fault-tolerant quantum-gate operations with trapped 9Be+ ions by use of stimulated Raman transitions.Comment: 9 pages, 4 figure

    Potential for efficient frequency conversion at high average power using solid state nonlinear optical materials

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    High-average-power frequency conversion using solid state nonlinear materials is discussed. Recent laboratory experience and new developments in design concepts show that current technology, a few tens of watts, may be extended by several orders of magnitude. For example, using KD*P, efficient doubling (>70%) of Nd:YAG at average powers approaching 100 KW is possible; and for doubling to the blue or ultraviolet regions, the average power may approach 1 MW. Configurations using segmented apertures permit essentially unlimited scaling of average power. High average power is achieved by configuring the nonlinear material as a set of thin plates with a large ratio of surface area to volume and by cooling the exposed surfaces with a flowing gas. The design and material fabrication of such a harmonic generator are well within current technology
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