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Relationship between metabolic syndrome and osteoarthritis: The Fasa Osteoarthritis Study
An association between metabolic syndrome (MeS) and osteoarthritis (OA) has been
reported in recent years; however, conflicting
findings have been reported regarding this matter.
Inhere we evaluated the relationship between different components of MeS and OA in a Fasa
osteoarthritis registry (FOAS).
Methods: The registry includes all OA cases who referred to Fasa hospital (Iran) since 2013. Overall, 131
patients with OA with a Kellgren & Lawrence (K&L) score >1 and 261 controls were compared.
Results: Overall, 82.4% of individuals in the OA group and 40.8% of participants in the control group had
MeS (P < 0.001). Patients with OA had a 6.8 (95% CI: 4.1–11.4) higher chance of acquiring MeS. After
adjusting for sex, age, and BMI, odds’ ratio (OR) for acquiring MeS in OA group increased to 10.9 (95% CI:
5.5–21.8). Among MeS criteria’s, high waist circumference (WC) has strongest correlation for acquiring
OA (OR = 27.535, 95% CI: 6.003–126.306).
Conclusion: Our
findings revealed that metabolic markers are strongly associated with OA and the
addition of each component of the MeS, significantly increases the risk of developing OA, therefore
control of metabolic factors and appropriate screening must be considered in health policy making and
prevention programs