Antimicrobial Evaluation of 6-chloro-5<i>H</i>-benzobenzo[a]phenoxazin-5-one and 6-chloro-5<i>H</i>-naphtho[2,1-b]pyrido[3,2-e][1,4]oxazin-5-one and their derivatives determine by diffusion method.

<p>Inhibition zone diameter (mm). Minimum inhibition concentration (μg/mL) in bracket ().</p

Immunotherapy with lipid protein syndrome and diagnosing asthma

<p>Docked poses of (a) 1 and (b) 2 toward the binding site cavity of PBP.</p

Reaction conditions are the same as in Fig 2.

<p>Reaction conditions are the same as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0163467#pone.0163467.g002" target="_blank">Fig 2</a>.</p

Synthesis of polycyclic mixed phenothiazine-phenoxazine organic dyes

<p>A convenient synthesis of new polycyclic mixed phenothiazine-phenoxazine compounds is described. The cross-coupling of 2,4-diaminothiophenol with 2,3-dichloro-1,4-naphthoquin one at room temperature gave reddish brown 10-amino-6-chlorobenzo[a]phenoxazin-5-one which was converted into a benzoxazinophenothiazin-12-amine in 58% yield via reaction with 2-aminothiophenol under anhydrous basic conditions. A three-component one-pot synthesis improved the yield of benzoxazinophenothia-12-amine to 81% a in shorter time compared to two steps reactions. The synthesis of new azomethine derivatives of benzo[a]benzo[5,6] [1,4] oxazino [3,2-c] phenothiazin-12-amine with extended conjugations and excellent yields were also reported. The structural assignments of the prepared compounds were established by combine Ultraviolet-Visible, Fourier Transform Infrared, ¹H and ¹³C Nuclear Magnetic Resonance Spectroscopies, Mass Spectrometry and elemental analytical data. The ease of preparations in high yields and their intense colourations make these compounds applicable as dyestuffs.</p

Physicochemical properties for drug-likeness.

<p>Physicochemical properties for drug-likeness.</p

Docking calculations of the compounds toward PBP.

<p>Docking calculations of the compounds toward PBP.</p