SARS-COV-2 MRNA vaccine-associated cutaneous vasculitis

During the coronavirus disease 2019 pandemic, global approach was to isolate populations with quarantine procedures to reduce the spread of this deadly virus until effective treatments are found or vaccines are developed. mRNA-based vaccines became available in the United States in March 2020. The Food and Drug Administration even issued an Emergency Use Authorization for individuals 16 years and older in December 2020. However, these rapid developments have brought along other problems such as possible side effects. As we develop and test a new treatment, it became clear how important side-effect management is. Here, we present a case of cutaneous vasculitis that developed on the fourth day of SARS-CoV-2 mRNA vaccination. The patient was successfully treated with medium-dose methylprednisolone

Correlation of [18F]FDG PET activity with expressions of Ki-67 in non-small-cell lung cancer

Background: Lung carcinoma is the most commonly diagnosed cancer throughout the world and is the leading cause of cancer-related deaths. Non-small cell lung cancer (NSCLC) accounts for up to 80% of newly diagnosed lung cancer cases. This study aimed to investigate the relationship between Ki-67 proliferation index (PI) and the maximum standardized uptake value (SUVmax) obtained from [18F]FDG PET/CT in NSCLCs and whether prognosis was predicted with SUVmax values.Material and methods: This retrospective study included biopsy and resection materials of 41 patients, who were examined in the pathology laboratory of Konya Training and Research Hospital between January 2010 and December 2019, and diagnosed with NSCLC, and whose [18F]FDG PET/CT images were present.Results: There was no significant difference between histopathological subtypes in terms of age (p = 0.077), Ki-67 PI (p = 0.454), and SUVmax (p = 0.143). No correlation was observed between Ki-67 PI and SUVmax values obtained from [18F]FDG PET/CT (p = 0.338, r = 0.153). There was no significant correlation between Ki-67 PI and tumor diameter (p = 0.531). The SUVmax value was found to be lower (12.78 ± 6.14) in tumors measuring ≤ 2.5 in diameter and higher (18.46 ± 7.81) in tumors measuring > 2.5 cm (p = 0.027). Metastases not proven histopathologically but detected in [18F]FDG PET/CT were found to have no significant correlation with Ki-67 and SUVmax values (p = 0.881, p = 0.837).Conclusions: This study showed that there was no significant relationship between Ki-67 PI and SUVmax value obtained from [18F]FDG PET/CT in NSCLC tumors

Synthesis, antimicrobial and in silico studies of new 2,5-disubstituted benzoxazole derivative

In this study, a new 2.5-substituted benzoxazole derivative compound was synthesized in three steps, its antimicrobial activities were determined by the microdilution method on Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Candida albicans ATCC 10231 and their isolates, and also in silico studies were performed. The structure of the compound was illuminated by 1H-NMR and 13C-NMR spectroscopy and HRMS, and the resulting analysis results proved our structure. When the antimicrobial activity results were examined, although the reference drugs generally showed better antimicrobial activity, it was observed that the synthesized compound showed very promising activity against Candida albicans isolate with MIC: 16 ug/mL. Molecular docking studies were conducted to understand the mechanism of the compound's good antimicrobial effect against Candida albicans isolate (PDB: 5TZ1). Estimated ADME profiles were determined. In addition, quantum chemical calculations were made with the DFT/B3LYP method in the 6-311G (d,p) basic set, the structural properties, geometry, electronic and thermodynamic properties of the molecule were determined and the results were displayed. [Med-Science 2021; 10(2.000): 400-8