78 research outputs found
Granular cell tumor presenting as a tongue nodule: two case reports
<p>Abstract</p> <p>Introduction</p> <p>Granular cell tumor is an uncommon neoplasm that can occur in any part of the body, including the orofacial region. The tumor is usually benign, but there are reports of cases in which the tumor shows a locally aggressive behavior, malignancy, and distant metastases. The most widely accepted hypothesis is that granular cell tumor arises from the altered metabolism of Schwann cells. The tumor is typically asymptomatic and appears as a nodule that does not exceed 3 cm.</p> <p>Case presentation</p> <p>In case 1, a 26-year-old Caucasian man was seen at the Oral Medicine out-patient clinic of the São José dos Campos Dental School, Universidade Estadual Paulista, with a 'small blister on the tongue', which he had noted approximately three years ago. The nodule was located on the dorsum of the tongue, measured about 1.5 cm in diameter, and was not tender to palpation. Treatment consisted of an excisional biopsy performed on the basis of the diagnostic hypothesis of granular cell tumor, which was confirmed by microscopic analysis. In case 2, a 31-year-old Caucasian woman attended the out-patient clinic of the São José dos Campos Dental School, Universidade Estadual Paulista, with a five-year history of a 'painful lump on the tongue'. Intra-oral examination revealed the presence of a nodular lesion measuring approximately 0.8 cm in diameter, which was located deep in the submucosa of the right lateral margin of the tongue. Treatment consisted of an excisional biopsy performed on the basis of the differential diagnosis of neurofibroma and granular cell tumor. Microscopic analysis defined the final diagnosis of granular cell tumor.</p> <p>Conclusions</p> <p>Granular cell tumor is an uncommon tumor that must be carefully diagnosed and treated correctly.</p
The presence of Helicobacter pylori in oral cavities of patients with leukoplakia and oral lichen planus
Derivation and validation of a risk-factor model for detection of oral potentially malignant disorders in populations with high prevalence
Background:Oral and pharyngeal cancers constitute the sixth most common type of cancer globally, with high morbidity and mortality. In many countries, most cases of oral cancer arise from long-standing, pre-existing lesions, yet advanced malignancies prevail. A new approach to early detection is needed. We aimed to validate a model for screening so that only high-risk individuals receive the clinical examination.Methods:A community-based case-control study (n1029) in rural Sri Lanka assessed risk factors and markers for oral potentially malignant disorders (OPMD) by administering a questionnaire followed by an oral examination. We then developed a model based on age, socioeconomic status and habits of betel-quid chewing, alcohol drinking and tobacco smoking, with weightings based on odds ratios from the multiple logistic regression. A total, single score was calculated per individual. Standard receiver-operator characteristic curves were plotted for the total score and presence of OPMD. The model was validated on a new sample of 410 subjects in a different community.Results:A score of 12.0 produced optimal sensitivity (95.5%), specificity (75.9%), false-positive rate (24.0%), false-negative rate (4.5%), positive predictive value (35.9%) and negative predictive value (99.2%).Conclusion:This model is suitable for detection of OPMD and oral cancer in high-risk communities, for example, in Asia, the Pacific and the global diaspora therefrom. A combined risk-factor score of 12.0 was optimal for participation in oral cancer/OPMD screening in Sri Lanka. The model, or local adaptations, should have wide applicability
Oral lichen planus clinical characteristics in Italian patients: a retrospective analysis
The possible premalignant character of oral lichen planus and oral lichenoid lesions: a prospective five-year follow-up study of 192 patients
Efficacy of glandular irrigation and sialendoscopy in salivary glands affected by Sjögren's syndrome
Sjögren’s syndrome is a progressive disease characterized by a gradual and irreversible decrease in both the quantity and quality of saliva that eventually leads to xerostomia. Hyposalivation can increase susceptibility to dental caries, dental erosion, fungal and bacterial infections, digestive disorders, loss of taste, and difficulty in swallowing, which reduces the quality of life in patients. To date, no ideal medications have been available to treat hyposalivation and xerostomia effectively, and consequently, there is still a need for development of therapeutic agents and strategies. Recently, ductal irrigation and sialendoscopy of the parotid and submandibular glands have gained popularity for its efficacy as palliative treatments. In glandular irrigation, Stensen’s ducts in the parotid glands and Wharton’s ducts in the submandibular glands are irrigated with, for example, saline or corticosteroids by using a cannula. In sialendoscopy, endoscopes that are small enough to be introduced into the salivary ducts of the major salivary glands are utilized. Through these endoscopes, the ducts can be irrigated under direct visualization, blockages can be removed, and strictures can be dilated. An overview of both techniques and their efficacy in relieving symptoms of xerostomia and hyposalivation in patients with Sjögren’s syndrome is presented
Oral Manifestations of Dermatologic Disease: A Focus on Lichenoid Lesions
Lichenoid changes in the oral mucosa can be encountered in a wide range of lesions with varied etiologies including immune-mediated disorders, reactions to systemic medications and to dental materials. Dysplasia of the oral cavity can exhibit a lichenoid histology, which may mask the potentially cancerous component. Another unusual clinical disease, proliferative verrucous leukoplakia, can often mimic oral lichen planus clinically requiring careful correlation of the clinical and pathologic features
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