CONTENT-BASED IMAGE RETRIEVAL USING ENHANCED HYBRID METHODS WITH COLOR AND TEXTURE FEATURES

Content-based image retrieval (CBIR) automatically retrieves similar images to the query image by using the visual contents (features) of the image like color, texture and shape. Effective CBIR is based on efficient feature extraction for indexing and on effective query image matching with the indexed images for retrieval. However the main issue in CBIR is that how to extract the features efficiently because the efficient features describe well the image and they are used efficiently in matching of the images to get robust retrieval. This issue is the main inspiration for this thesis to develop a hybrid CBIR with high performance in the spatial and frequency domains. We propose various approaches, in which different techniques are fused to extract the statistical color and texture features efficiently in both domains. In spatial domain, the statistical color histogram features are computed using the pixel distribution of the Laplacian filtered sharpened images based on the different quantization schemes. However color histogram does not provide the spatial information. The solution is by using the histogram refinement method in which the statistical features of the regions in histogram bins of the filtered image are extracted but it leads to high computational cost, which is reduced by dividing the image into the sub-blocks of different sizes, to extract the color and texture features. To improve further the performance, color and texture features are combined using sub-blocks due to the less computational cos

CONTENT-BASED IMAGE RETRIEVAL USING ENHANCED HYBRID METHODS WITH COLOR AND TEXTURE FEATURES

Content-based image retrieval (CBIR) automatically retrieves similar images to the query image by using the visual contents (features) of the image like color, texture and shape. Effective CBIR is based on efficient feature extraction for indexing and on effective query image matching with the indexed images for retrieval. However the main issue in CBIR is that how to extract the features efficiently because the efficient features describe well the image and they are used efficiently in matching of the images to get robust retrieval. This issue is the main inspiration for this thesis to develop a hybrid CBIR with high performance in the spatial and frequency domains. We propose various approaches, in which different techniques are fused to extract the statistical color and texture features efficiently in both domains. In spatial domain, the statistical color histogram features are computed using the pixel distribution of the Laplacian filtered sharpened images based on the different quantization schemes. However color histogram does not provide the spatial information. The solution is by using the histogram refinement method in which the statistical features of the regions in histogram bins of the filtered image are extracted but it leads to high computational cost, which is reduced by dividing the image into the sub-blocks of different sizes, to extract the color and texture features. To improve further the performance, color and texture features are combined using sub-blocks due to the less computational cos

Critical Role of Non-Muscle Myosin Light Chain Kinase in Thrombin-Induced Endothelial Cell Inflammation and Lung PMN Infiltration

The pathogenesis of acute lung injury (ALI) involves bidirectional cooperation and close interaction between inflammatory and coagulation pathways. A key molecule linking coagulation and inflammation is the procoagulant thrombin, a serine protease whose concentration is elevated in plasma and lavage fluids of patients with ALI and acute respiratory distress syndrome (ARDS). However, little is known about the mechanism by which thrombin contributes to lung inflammatory response. In this study, we developed a new mouse model that permits investigation of lung inflammation associated with intravascular coagulation. Using this mouse model and in vitro approaches, we addressed the role of non-muscle myosin light chain kinase (nmMLCK) in thrombin-induced endothelial cell (EC) inflammation and lung neutrophil (PMN) infiltration. Our in vitro experiments revealed a key role of nmMLCK in ICAM-1 expression by its ability to control nuclear translocation and transcriptional capacity of RelA/p65 in EC. When subjected to intraperitoneal thrombin challenge, wild type mice showed a marked increase in lung PMN infiltration via expression of ICAM-1. However, these responses were markedly attenuated in mice deficient in nmMLCK. These results provide mechanistic insight into lung inflammatory response associated with intravascular coagulation and identify nmMLCK as a critical target for modulation of lung inflammation

Self-reported health and smoking status, and body mass index: a case-control comparison based on GEN SCRIP (GENetics of SChizophRenia In Pakistan) data

Introduction Individuals with schizophrenia are at a high risk of physical health comorbidities and premature mortality. Cardiovascular and metabolic causes are an important contributor. There are gaps in monitoring, documenting and managing these physical health comorbidities. Because of their condition, patients themselves may not be aware of these comorbidities and may not be able to follow a lifestyle that prevents and manages the complications. In many low-income and middle-income countries including Pakistan, the bulk of the burden of care for those struggling with schizophrenia falls on the families.Objectives To determine the rate of self-reported physical health disorders and risk factors, like body mass index (BMI) and smoking, associated with cardiovascular and metabolic disorders in cases of schizophrenia compared with a group of mentally healthy controls.Design A case-controlled, cross-sectional multicentre study of patients with schizophrenia in Pakistan.Settings Multiple data collection sites across the country for patients, that is, public and private psychiatric OPDs (out patient departments), specialised psychiatric care facilities, and psychiatric wards of teaching and district level hospitals. Healthy controls were enrolled from the community.Participants We report a total of 6838 participants’ data with (N 3411 (49.9%)) cases of schizophrenia compared with a group of healthy controls (N 3427 (50.1%)).Results BMI (OR 0.98 (CI 0.97 to 0.99), p=0.0025), and the rate of smoking is higher in patients with schizophrenia than in controls. Problems with vision (OR 0.13 (0.08 to 0.2), joint pain (OR 0.18 (0.07 to 0.44)) and high cholesterol (OR 0.13 (0.05 to 0.35)) have higher reported prevalence in controls. The cases describe more physical health disorders in the category ‘other’ (OR 4.65 (3.01 to 7.18)). This captures residual disorders not listed in the questionnaire.Conclusions Participants with schizophrenia in comparison with controls report more disorders. The access in the ‘other’ category may be a reflection of undiagnosed disorders