This data was acquired from an experiment in which measures of synaptic excitatory and inhibitory activity of the primary motor cortex were taken using transcranial magnetic stimulation (TMS), both before and after a 20-minute bout of high-intensity interval cycling exercise. We then examined the effect of D2 receptor blockade (800mg sulpiride) on these measures within a randomised, double-blind, placebo-controlled, crossover design. </p