5 research outputs found
Terapijski problemi pacijenata sa kardiovaskularnim bolestima na prijemu u bolnicu
In patients with cardiovascular diseases drug-related problems (DRPs) can be
associated with hospitalization or rehospitalization. The aim of the research was to analyse
DRPs in the cardiology department on admission to the hospital. All patient records on
admission to the cardiology department of the Clinical Hospital Center Zvezdara during
2018., were analyzed. Demographic and treatment data of the patient before admission to
the hospital were collected. DRPs associated with pre-hospital treatment were identified and
classified according to the PCNE (Pharmaceutical Care Network Europe, version 9.1)
classification. DRPs were also evaluated as cause of the patient's hospitalization. Data were
analyzed descriptively and with linear regression analysis. During the research period, 143
patients were admitted to the cardiology department, with an average age of 69.75 Ā± 10.11
years, of which 65.7% were male. Patients had an average of 4.36Ā±2.13 diagnoses and
5.24Ā±3.39 medications on admission. We observed 1.85Ā±1.37 DRPs per patient (range 0-5).
The most common DRP (75.6%) was lack of ā„1 drugs in the therapy preceding the
admission, most often statins (30.1% of patients), beta-blockers (25.9%), angiotensin-
converting enzyme inhibitors (17.5%) and antiarrhythmics/anticoagulants (12.6%). In 96
patients (67.1%) the identified DRPs could be associated with the cause of hospitalization.
Atrial fibrillation was the predictor of the number of DRPs in patients (p <0.001). In most
cardiovascular patients, the cause of hospitalization could be associated with DRPs before
admission. Incomplete therapy of the patient was commonly observed, the cause of which
may be inadequate prescribing or lack of adherence of the patient.Pacijenti sa kardiovaskularnim bolestima susreÄu se sa brojnim problemima u terapiji
od kojih pojedini mogu biti uzrok hospitalizacije ili rehospitalizacije. Cilj istraživanja je bio da
se prikaže analiza terapijskih problema pacijenata na odeljenju kardiologije, prilikom
prijema u bolnicu. Analizirani su kartoni svih pacijenata primljenih na odeljenje kardiologije,
KliniÄko-bolniÄkog centra Zvezdara tokom 2018. godine. Prikupljeni su demografski i podaci
o celokupnoj terapiji pacijenta pre prijema u bolnicu. Identifikovani su problemi u vezi sa
terapijom pre prijema u bolnicu i klasifikovani su prema PCNE (Pharmaceutical Care
Network Europe, verzija 9.1) klasifikaciji. TakoÄe, procenjeno je da li problemi u vezi sa
terapijom mogu biti uzrok hospitalizacije pacijenta. Podaci su analizirani deskriptivno i
primenom linearne regresione analize. U periodu istraživanja 143 pacijenta je primljeno na
odeljenje kardiologije, proseÄne starosti 69,75Ā±10,11 godina, od kojih je 65,7% bilo muÅ”kog
pola. Pacijenti su u proseku imali 4,36Ā±2,13 dijagnoze i 5,24Ā±3,39 lekova na prijemu.
UtvrÄeno je prisustvo 1,85Ā±1,37 terapijskih problema po pacijentu (opseg 0-5). NajÄeÅ”Äi
terapijski problem (75,6%) bio je nedostatak ā„1 leka u terapiji i to najÄeÅ”Äe statina (30,1%
pacijenata), beta-blokatora (25,9%), inhibitora angiotenzin-konvertujuÄeg enzima (17,5%) i
antiaritmika/anitkoagulanasa (12,6%). Kod 96 pacijenata (67,1%) su identifikovani
terapijski problemi dovedeni u vezu sa uzrokom hospitalizacije. Prediktivni faktor za broj
terapijskih problema kod pacijenata je bilo prisustvo atrijalne fibrilacije u anamnezi
(p<0,001). Uzrok hospitalizacije pacijenata sa kardiovaskularnim bolestima se Äesto može
povezati sa problemima u terapiji pre prijema. NajÄeÅ”Äe se uoÄava nepotpuna terapija
pacijenta Äiji uzrok može biti neodgovarajuÄe propisivanje ili nedostatak adherence
pacijenta.VIII Kongres farmaceuta Srbije sa meÄunarodnim uÄeÅ”Äem, 12-15.10.2022. Beogra
Pregled kliniÄki znaÄajnih interakcija u terapiji kardiovaskularnih bolesti kod pacijenata na prijemu u bolnicu
Clinically significant drug-drug interactions (DDIs) are expected in patients with
cardiovascular diseases due to the number of drugs in therapy. The aim of the research was
to analyze DDIs during treatment which preceeded the admission to the cardiology
department. In the cardiology department of the Clinical Hospital Center Zvezdara, the
treatment of patients with ā„2 drugs before admission was analyzed. DDIs were identified
using the Lexicomp database (Lexi-Interact). Data were analyzed descriptively and with
linear regression analysis. During research, out of 132 participants 88.6% had ā„1, while
41.7% had ā„5 DDIs. The total number of DDIs was 648 (median 3, range 0-19). Men
constituted 64.4% of the population, with a median age of 70 years (32-90). Patients had 4
diagnoses (1-13) and 6 medications on admission (2-15). In 3.8% of patients,
contraindicated DDIs of anticholinergics were observed, 23.5% had DDIs that required
caution or a change in therapy, while interactions requiring follow-up were observed in
86.4% of patients. Angiotensin-converting enzyme inhibitors (30.4%), acetylsalicylic acid
(26.6%) and loop diuretics (16.5%) were most frequently involved in DDIs, while the most
common adverse events could be renal failure (21.5%), hypotension 19.7%) and bleeding
(13.7%). The number of drugs in therapy was a predictor of DDIs (p <0.001). Patients with
cardiovascular disease are often exposed to polypharmacy and consequently DDIs.
Cardiovascular drugs were most frequently involved in DDIs, but contraindicated DDIs were
present in anticholinergic drugs. In patients with cardiovascular diseases, monitoring of
renal function, hypotension and bleeding is required.KliniÄki znaÄajne interakcije (KZI) oÄekuju se kod pacijenata sa kardiovaskularnim
bolestima usled veÄeg broja lekova u terapiji. Cilj istraživanja je bio da se identifikuju i
analiziraju KZI pacijenata koje su prethodile prijemu na odeljenje kardiologije. U KliniÄko-
bolniÄkom centru Zvezdara, na odeljenju kardiologije, analizirana je terapija pacijenata sa ā„2
leka pre prijema. KZI su identifikovane upotrebom baze Lexicomp (Lexi-Interact). Podaci su
analizirani deskriptivno i primenom linearne regresione analize. Od 132 uÄesnika u
istraživanju 88,6% je imalo ā„1, dok je 41,7% imalo ā„5 KZI. Ukupan broj KZI bio je 648
(medijana 3, opseg 0-19). U populaciji je bilo 64,4% muŔkaraca medijane starosti 70 godina
(32-90). Pacijenti su imali 4 dijagnoze (1-13) i 6 lekova na prijemu (2-15). Kod 3,8%
pacijenata utvrÄene su KZI antiholinergika koje se smatraju kontraindikovanim. Približno
jedna Äetvrtina pacijenata (23,5%) je imala KZI koja zahteva oprez ili izmenu u terapiji dok
su kod 86,4% pacijenata uoÄene interakcije koje zahtevaju praÄenje ishoda. NajÄeÅ”Äe su u KZI
stupali inhibitori angiotenzin-konvertujuÄeg enzima (30,4%), acetilsalicilna kiselina (26,6%)
i diuretici petlje (16,5%) dok su najÄeÅ”Äi neželjeni ishodi mogli biti bubrežna insuficijencija
(21,5%), hipotenzija (19,7%) i krvarenje (13,7%). Broj lekova u terapiji bio je prediktor za
KZI (p<0,001). Pacijenti sa kardiovaskularnim bolestima su Äesto izloženi polifarmaciji i
poslediÄno veÄem broju KZI. U KZI su najÄeÅ”Äe stupali lekovi u terapiji kardiovaskularnih
bolesti ali su kontraindikovane KZI bile zastupljene kod antiholinergiÄkih lekova. Kod
pacijenata sa kardiovaskularnim bolestima potrebno je praÄenje renalne funkcije,
hipotenzije i krvarenja.VIII Kongres farmaceuta Srbije sa meÄunarodnim uÄeÅ”Äem, 12-15.10.2022. Beogra
Drug-Related Problems Prior to Hospitalization on Internal Medicine Wards
Drug-related hospitalizations pose a significant burden to the health-care system. The aim
was to investigate the prevalence of drug-related problems (DRPs) and their association with hospital
admissions in five internal medicine wards. The study included patients admitted to the nephrology,
cardiology, gastroenterology, endocrinology, and geriatric wards. The Pharmaceutical Care Network
Europe classification V9.1 was used for identifying DRPs. In total, 535 patients participated in the study.
We identified 954 DRPs (range 1-7) in 80.7% of patients. Most DRPs were identified on the endocrinology,
cardiology, and geriatric wards, and they were associated with the efficacy of treatment (71.4%), adverse
drug events (10.2%), and unnecessary drug treatment (18.4%). DRPs were associated with the cause of
hospitalization in 74.4% of patients on the nephrology ward, 60.1% and 60.6% of patients on the cardiology
and endocrinology wards, respectively, whereas this number was lower on the geriatric and gastroenterology
wards (26.9% and 8.9%, respectively). Suboptimal drug treatment due to medication omissions was often
associated with the potential cause of hospital admission. Focusing on patients with specific diseases and
DRPs, rather than reducing the number of medications in primary care, may be potentially rational in an
attempt to reduce drug-related hospitalizations
Thymus dacicus as a new source of antioxidant and antimicrobial metabolites
In a search for novel food additives functional food ingredients, chemical composition, and antioxidant and antimicrobial activities of Thymus dacicus Borbas (Lamiaceae) flowering aerial parts dry methanol extract and essential oil were tested for the first time. HPLC analysis of the extract revealed that among dominant polyphenols, rosmarinic acid was the most abundant (71.33 +/- 1.11 mg/g). Monoterpenes geranial (34.4%) and neral (23.9%) prevailed in the oil, analyzed by GC and GC-MS. The extract showed pronounced antioxidant activity, with FRAP value of 5.16 +/- 0.19 mmol Fe2+/g, OH radical SC50 of 18.85 Āµg/mL (determined by 2-deoxyribose assay) and DPPH radical SC50 of 28.04 Āµg/mL. Eight out of ten tested microbial strains were susceptible to the oil in microdilution test. Furthermore, for the combination of the oil and vancomycin/gentamicin, synergism was demonstrated against MRSA, Klebsiella pneumoniae and Escherichia coli in checkerboard test. Obtained results encourage further research of this herb as potentially beneficial ingredient in foodstuffs