Probability of Semantic Similarity and N-grams Pattern Learning for Data Classification

Semantic learning is an important mechanism for the document classification, but most classification approaches are only considered the content and words distribution. Traditional classification algorithms cannot accurately represent the meaning of a document because it does not take into account semantic relations between words. In this paper, we present an approach for classification of documents by incorporating two similarity computing score method. First, a semantic similarity method which computes the probable similarity based on the Bayes' method and second, n-grams pairs based on the frequent terms probability similarity score. Since, both semantic and N-grams pairs can play important roles in a separated views for the classification of the document, we design a semantic similarity learning (SSL) algorithm to improves the performance of document classification for a huge quantity of unclassified documents. The experiment evaluation shows an improvisation in accuracy and effectiveness of the proposal for the unclassified documents

Designing of Hybrid Semi-Circle Coupled Slot Loaded Rectangular Microstrip Antennas for Wireless Applications

ABSTRACT: In this paper a design of hybrid semi-circle coupled slot loaded rectangular microstrip antennas are presented for multiband operation. The proposed antennas are consisting a novel geometry of semi-circle radiating patch which is superimposed on conventional rectangular microstrip antenna (CRMSA) to form a hybrid model. The proposed antennas are excited through a simple 50-Ω microstripline feed using quarter wave impedance matching transformer. These antennas are operates between the frequencies from 1.87 to 6.50 GHz at different frequency bands and gives a highest virtual size reduction of 34.14% with broadside radiation characteristics. These antennas are useful for the applications such as WLAN, WiMax and Bluetooth. The important antenna parameters such as bandwidth, return loss, gain and radiation pattern are discussed and presented

STK295900, a Dual Inhibitor of Topoisomerase 1 and 2, Induces G<inf>2</inf> Arrest in the Absence of DNA Damage

STK295900, a small synthetic molecule belonging to a class of symmetric bibenzimidazoles, exhibits antiproliferative activity against various human cancer cell lines from different origins. Examining the effect of STK295900 in HeLa cells indicates that it induces G2 phase arrest without invoking DNA damage. Further analysis shows that STK295900 inhibits DNA relaxation that is mediated by topoisomerase 1 (Top 1) and topoisomerase 2 (Top 2) in vitro. In addition, STK295900 also exhibits protective effect against DNA damage induced by camptothecin. However, STK295900 does not affect etoposide-induced DNA damage. Moreover, STK295900 preferentially exerts cytotoxic effect on cancer cell lines while camptothecin, etoposide, and Hoechst 33342 affected both cancer and normal cells. Therefore, STK295900 has a potential to be developed as an anticancer chemotherapeutic agent. © 2013 Kim et al

Microwave assisted solvent free synthesis of 1,3-diphenylpropenones

<p>Abstract</p> <p>Background</p> <p>1,3-Diphenylpropenones (chalcones) are well known for their diverse array of bioactivities. Hydroxyl group substituted chalcones are the main precursor in the synthesis of flavonoids. Till date various methods have been developed for the synthesis of these very interesting molecules. Continuing our efforts for the development of simple, eco-friendly and cost-effective methodologies, we report here a solvent free condensation of aryl ketones and aldehydes using iodine impregnated alumina under microwave activation. This new protocol has been applied to a variety of substituted aryl carbonyls with excellent yield of substituted 1,3-diphenylpropenones.</p> <p>Results</p> <p>Differently substituted chalcones were synthesized using iodine impregnated neutral alumina as catalyst in 79-95% yield in less than 2 minutes time under microwave activation without using any solvent. The reaction was studied under different catalytic conditions and it was found that molecular iodine supported over neutral alumina gives the best yield. The otherwise difficult single step condensation of hydroxy substituted aryl carbonyls is an attractive feature of this protocol to obtain polyhydroxychalcones in excellent yields. In order to find out the general applicability of this new endeavor it was successfully applied for the synthesis of 15 different chalcones including highly bioactive prenylated hydroxychalcone xanthohumol.</p> <p>Conclusion</p> <p>A new, simple and solvent free method was developed for the synthesis of substituted chalcones in environmentally benign way. The mild reaction conditions, easy work-up, clean reaction profiles render this approach as an interesting alternative to the existing methods.</p