(E) Enol ethers from the stereoselective reduction of α-alkoxy-β-ketophosphonates and Wittig type reaction

International audienc

(E) Enol ethers from the stereoselective reduction of α-alkoxy-β-ketophosphonates and Wittig type reaction

International audienc

Highly Wolff selective Rh(II) catalysed decomposition of alpha-diazo-beta-ketophosphonates having an oxygen atom adjacent to the gama-position

International audienc

Preparation of amide-linked pseudo-disaccharides by the carboxymethylglycoside lactone (CMGL) strategy

International audienc

Synthetic Studies on the MARDI Cascade : Stereoselective Synthesis of Heterocyclic Seven-Membered

International audienc

Bis-(O)-acetylated derivative of 4,5-dihydroxy-2,3-pentanedione (DPD): a convenient stable precursor of quorum sensing autoinducer AI-2

International audienc

Mechanisms and synthetic modulators of AHL-dependent gene regulation.

International audienc

Synthetic homoserine lactone-derived sulfonylureas as inhibitors of Vibrio fischeri quorum sensing regulator

International audienceA series of 9 homoserine lactone-derived sulfonylureas substituted by an alkyl chain, some of them bearing a phenyl group at the extremity, have been prepared. All compounds were found to inhibit the action of 3-oxo-hexanoyl-l-homoserine lactone, the natural inducer of bioluminescence in the bacterium Vibrio fischeri, the aliphatic compounds being more active than their phenyl-substituted counterparts. Molecular modelling studies performed on the most active compound in each series suggest that the antagonist activity could be related to the perturbation of the hydrogen-bond network in the ligand–protein complexes