Heritability, variance proportions, and stratified correlations of MDD.

<p>h² = heritability, r_G = genetic correlation, c² = shared family environment, r_C = shared family environment correlation.</p

Phenotypic correlations of MDD status (absent = 0, affected = 1) between kinship dyads.

<p>Estimates from 500 jack-knifed replicates that sampled a single pair from each family for full siblings (N families with one or more pairs = 4306), full sisters (N = 2239), full brothers (N = 1161), opposite sex full-siblings (N = 2426), parent-child (N = 3402), grandparent-grandchild (N = 391), avuncular (aunt/uncle-niece/nephew N = 1826), first cousins (N = 1194).</p

The effects of social and demographic variables on MDD risk.

<p>The effects of social and demographic variables on MDD risk.</p

Sociodemographic comparison of GS:SFHS and the Scottish population.

<p>* People aged 16–74 years</p><p>^a Scottish Executive (2012)</p><p>^b Scottish Executive (2006)</p><p>Sociodemographic comparison of GS:SFHS and the Scottish population.</p

Age of onset distribution.

<p>Dashed line is the mean.</p

Kaplan-Meier survival curves for age of onset by age group.

<p>Kaplan-Meier survival curves for age of onset by age group.</p

Number of informative relationships for MDD and AOO pedigree analysis in GS:SFHS.

<p>Number of informative relationships for MDD and AOO pedigree analysis in GS:SFHS.</p

Decreases in white matter integrity in t(1;11) translocation carriers (n = 7) versus non-carriers (n = 13) and in patients (n = 34) versus controls (n = 33).

<p>Deceased white matter integrity in translocation carriers versus non-carriers (shown in red), and in the patient group versus the control group (shown in blue). Individual figures (a-d) present the main cluster peak co-ordinates for the translocation carrier versus non-carrier comparison; (a) left genu of corpus callosum [–3, 28, 6], (b) right inferior fronto-occiptal fasciculus [29, 26, 15], (c) right acoustic radiation [20, 25, 0], and (d) right fornix [28, −24, −8]. For further details see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0130900#pone.0130900.t002" target="_blank">Table 2</a>. To aid visualization the results (pfwe < 0.05) are thickened using the “tbss-fill” command. Statistics for FA decreases in the patient group versus controls for these peaks; cluster 1: p = 0.023 at [-3, 28, 6; left genu of corpus callosum], cluster 2: p = 0.032 at [29, 26, 15; right fronto-occipital fasciculus], cluster 3: p = 0.012 at [11, 26, 14; right genu of corpus callosum], cluster 4: p = 0.033 at [20, 25, 0; right acoustic radiation], and cluster 5: p = 0.031 at [28, -24, -8; right fornix] i.e. for clusters 1–5 respectively, see, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0130900#pone.0130900.t002" target="_blank">Table 2</a>).</p

FA values extracted from clusters of differences between carrier and non-carrier groups.

<p>Individual figures represent FA values across the main clusters of differences from the comparison of translocation carrier versus non-carrier comparison; (a) cluster 1: genu of corpus callosum, (b) cluster 2: right inferior fronto-occiptal fasciculus, (c) right acoustic radiation, and (d) cluster 4: right fornix. C = control group, Patient = group with mixed psychoses, Non-carrier = family members not carrying translocation, Carrier = family members with the translocation.</p

Demographics and clinical measures.

<p>^# median and interquartile range and non-parametric Mann-Whitney U statistics applied.</p><p>Demographics and clinical measures.</p