M Theory from World-Sheet Defects in Liouville String

We have argued previously that black holes may be represented in a D-brane approach by monopole and vortex defects in a sine-Gordon field theory model of Liouville dynamics on the world sheet. Supersymmetrizing this sine-Gordon system, we find critical behaviour in 11 dimensions, due to defect condensation that is the world-sheet analogue of D-brane condensation around an extra space-time dimension in M theory. This supersymmetric description of Liouville dynamics has a natural embedding within a 12-dimensional framework suggestive of F theory.Comment: 17 pages LATEX, 1 epsf figure include

N=1 SUSY Conformal Block Recursive Relations

We present explicit recursive relations for the four-point superconformal block functions that are essentially particular contributions of the given conformal class to the four-point correlation function. The approach is based on the analytic properties of the superconformal blocks as functions of the conformal dimensions and the central charge of the superconformal algebra. The results are compared with the explicit analytic expressions obtained for special parameter values corresponding to the truncated operator product expansion. These recursive relations are an efficient tool for numerically studying the four-point correlation function in Super Conformal Field Theory in the framework of the bootstrap approach, similar to that in the case of the purely conformal symmetry.Comment: 12 pages, typos corrected, reference adde

Bulk correlation functions in 2D quantum gravity

We compute bulk 3- and 4-point tachyon correlators in the 2d Liouville gravity with non-rational matter central charge c<1, following and comparing two approaches. The continuous CFT approach exploits the action on the tachyons of the ground ring generators deformed by Liouville and matter ``screening charges''. A by-product general formula for the matter 3-point OPE structure constants is derived. We also consider a ``diagonal'' CFT of 2D quantum gravity, in which the degenerate fields are restricted to the diagonal of the semi-infinite Kac table. The discrete formulation of the theory is a generalization of the ADE string theories, in which the target space is the semi-infinite chain of points.Comment: 14 pages, 2 figure

High efficacy and low toxicity of weekly docetaxel given as first-line treatment for metastatic breast cancer

Background: Docetaxel is one of the most effective antitumor agents currently available for the treatment of metastatic breast cancer (MBC). This phase II multicenter study prospectively analyzed the efficacy and toxicity of docetaxel given on a weekly schedule as first-line treatment of metastatic breast cancer. Patients and Methods: All patients received docetaxel, 35 mg/m(2) weekly for 6 weeks, followed by 2 weeks of rest. Subsequent cycles ( 3 weeks of treatment, 2 weeks of rest) were given until a maximum of 5 cycles or disease progression. Premedication consisted of 8 mg dexamethasone intravenously 30 min prior to the infusion of docetaxel. Results: Fifty-four patients at a median age of 58 years with previously untreated MBC were included in the study. A median of 10 doses ( median cumulative dose 339 mg/m(2)) was administered ( range: 2 - 18). The overall response rate was 48.1% ( 95% CI: 34 - 61%, intent-to-treat). Median survival was 15.8 months and median time to progression was 5.9 months ( intent-to-treat). Hematological toxicity was mild with absence of neutropenia-related complications. Grade 3 neutropenia was observed in 3.7% of patients and grade 3 and 4 anemia was observed in 5.6 and 1.9% of patients, respectively. Conclusion: The weekly administration of docetaxel is highly efficient and safe as first-line treatment for MBC and may serve as an important treatment option specifically in elderly patients and patients with a reduced performance status. Copyright (C) 2005 S. Karger AG, Basel

Timelike Boundary Liouville Theory

The timelike boundary Liouville (TBL) conformal field theory consisting of a negative norm boson with an exponential boundary interaction is considered. TBL and its close cousin, a positive norm boson with a non-hermitian boundary interaction, arise in the description of the $c=1$ accumulation point of $c<1$ minimal models, as the worldsheet description of open string tachyon condensation in string theory and in scaling limits of superconductors with line defects. Bulk correlators are shown to be exactly soluble. In contrast, due to OPE singularities near the boundary interaction, the computation of boundary correlators is a challenging problem which we address but do not fully solve. Analytic continuation from the known correlators of spatial boundary Liouville to TBL encounters an infinite accumulation of poles and zeros. A particular contour prescription is proposed which cancels the poles against the zeros in the boundary correlator d(\o) of two operators of weight \o^2 and yields a finite result. A general relation is proposed between two-point CFT correlators and stringy Bogolubov coefficients, according to which the magnitude of d(\o) determines the rate of open string pair creation during tachyon condensation. The rate so obtained agrees at large \o with a minisuperspace analysis of previous work. It is suggested that the mathematical ambiguity arising in the prescription for analytic continuation of the correlators corresponds to the physical ambiguity in the choice of open string modes and vacua in a time dependent background.Comment: 28 pages, 1 figure, v2 reference and acknowledgement adde

Quantum-Gravitational Diffusion and Stochastic Fluctuations in the Velocity of Light

We argue that quantum-gravitational fluctuations in the space-time background give the vacuum non-trivial optical properties that include diffusion and consequent uncertainties in the arrival times of photons, causing stochastic fluctuations in the velocity of light ``in vacuo''. Our proposal is motivated within a Liouville string formulation of quantum gravity that also suggests a frequency-dependent refractive index of the particle vacuum. We construct an explicit realization by treating photon propagation through quantum excitations of $D$-brane fluctuations in the space-time foam. These are described by higher-genus string effects, that lead to stochastic fluctuations in couplings, and hence in the velocity of light. We discuss the possibilities of constraining or measuring photon diffusion ``in vacuo'' via $\gamma$-ray observations of distant astrophysical sources.Comment: 17 pages LATEX, uses axodraw style fil

Multi giant graviton systems, SUSY breaking and CFT

In this article, we describe giant gravitons in AdS_5 x S^5 moving along generic trajectories in AdS_5. The giant graviton dynamics is solved by proving that the D3-brane effective action reduces to that of a massive point particle in AdS_5 and therefore the solutions are in one to one correspondence with timelike geodesics of AdS_5. All these configurations are related via isometries of the background, which induce target space symmetries in the world volume theory of the D-brane. Hence, all these configurations preserve the same amount of supersymmetry as the original giant graviton, i.e. half of the maximal supersymmetry. Multiparticle configurations of two or more giant gravitons are also considered. In particular, a binary system preserving one quarter of the supersymmetries is found, providing a non trivial time-dependent supersymmetric solution. A short study on the dual CFT description of all the above states is given, including a derivation of the exact induced isometry map in the CFT side of the correspondence.Comment: latex, 27+1 pages. v2: comment on mixing of states in section 4.3 added, reference added, typos corrected, final versio

Higher Equations of Motion in Boundary Liouville Field Theory

In addition to the ordinary bulk higher equations of motion in the boundary version of the Liouville conformal field theory, an infinite set of relations containing the boundary operators is found. These equations are in one-to-one correspondence with the singular representations of the Virasoro algebra. We comment on the possible applications in the context of minimal boundary Liouville gravity.Comment: 18 page

Angular momentum of focused beams: beyond the paraxial approximation

We investigate in detail the focusing of a circularly polarized Laguerre-Gaussian laser beam ($\hbar \ell$ orbital angular momentum per photon; $\sigma=1/-1$ for left/right-handed polarization) by a high numerical aperture objective. The diffraction-limited focused beam has unexpected properties, resulting from a strong interplay between the angular spatial structure and the local polarization in the non-paraxial regime. In the region near the beam axis, and provided that $|\ell|\ge 2$ and $\ell$ and $\sigma$ have opposite signs, the energy locally counter-propagates and the projection of the electric field onto the focal plane counter-rotates with respect to the circular polarization of the incident beam. We explicitly show that the total angular momentum flux per unit power is conserved after focusing, as expected by rotational symmetry, but the spin and orbital separate contributions change.Comment: 10 pages, 9 figure

Non-Perturbative Effects in Matrix Models and D-branes

The large order growth of string perturbation theory in $c\le 1$ conformal field theory coupled to world sheet gravity implies the presence of $O(e^{-{1\over g_s}})$ non-perturbative effects, whose leading behavior can be calculated in the matrix model approach. Recently it was proposed that the same effects should be reproduced by studying certain localized D-branes in Liouville Field Theory, which were constructed by A. and Al. Zamolodchikov. We discuss this correspondence in a number of different cases: unitary minimal models coupled to Liouville, where we compare the continuum analysis to the matrix model results of Eynard and Zinn-Justin, and compact c=1 CFT coupled to Liouville in the presence of a condensate of winding modes, where we derive the matrix model prediction and compare it to Liouville theory. In both cases we find agreement between the two approaches. The c=1 analysis also leads to predictions about properties of D-branes localized in the vicinity of the tip of the cigar in SL(2)/U(1) CFT with c=26.Comment: 27 pages, lanlmac; minor change