A SIMPLE METHOD FOR ASSESSMENT OF MUSCLE MECHANICAL CAPACITIES FROM FUNCTIONAL MOVEMENT TASKS

The aim of the present study was to evaluate the level of agreement between the routinely used multiple-load method and a simple two-load method based on direct assessment of the F-V relationship from only 2 external loads applied. Twelve participants were tested on the maximum performance vertical jumps, cycling, bench press throws, and bench pull performed against a variety of different loads. All four tested tasks revealed both exceptionally strong relationships between the parameters of the 2 methods (median R = 0.98) and a lack of meaningful differences between their magnitudes (fixed bias below 3.4%). Therefore, addition of another load to the standard tests of various functional tasks typically conducted under a single set of mechanical conditions could allow for the assessment of the muscle mechanical properties, such as the muscle F, V, and P producing capacities

The Serbian version of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR)

The Juvenile Arthritis Multidimensional Assessment Report (JAMAR) is a new parent/patient-reported outcome measure that enables a thorough assessment of the disease status in children with juvenile idiopathic arthritis (JIA). We report the results of the cross-cultural adaptation and validation of the parent and patient versions of the JAMAR in the Serbian language. The reading comprehension of the questionnaire was tested in 10 JIA parents and patients. Each participating centre was asked to collect demographic, clinical data and the JAMAR in 100 consecutive JIA patients or all consecutive patients seen in a 6-month period and to administer the JAMAR to 100 healthy children and their parents. The statistical validation phase explored descriptive statistics and the psychometric issues of the JAMAR: the three Likert assumptions, floor/ceiling effects, internal consistency, Cronbach\u2019s alpha, interscale correlations, test\u2013retest reliability, and construct validity (convergent and discriminant validity). A total of 248 JIA patients (5.2% systemic, 44.3% oligoarticular, 23.8% RF-negative polyarthritis, 26.7% other categories) and 100 healthy children were enrolled in three centres. The JAMAR components discriminated healthy subjects from JIA patients. All JAMAR components revealed good psychometric performances. In conclusion, the Serbian version of the JAMAR is a valid tool for the assessment of children with JIA and is suitable for use both in routine clinical practice and clinical research

Soluplus® as an effective absorption enhancer of poorly soluble drugs in vitro and in vivo

a b s t r a c t As many new active pharmaceutical ingredients are poorly water soluble, solubility enhancers are one possibility to overcome the hurdles of drug dissolution and absorption in oral drug delivery. In the present work a novel solubility enhancing excipient (Soluplus Ò ) was tested for its capability to improve intestinal drug absorption. BCS class II compounds danazol, fenofibrate and itraconazole were tested both in vivo in beagle dogs and in vitro in transport experiments across Caco-2 cell monolayers. Each drug was applied as pure crystalline substance, in a physical mixture with Soluplus Ò , and as solid solution of the drug in the excipient. In the animal studies a many fold increase in plasma AUC was observed for the solid solutions of drug in Soluplus Ò compared to the respective pure drug. An effect of Soluplus Ò in a physical mixture with the drug could be detected for fenofibrate. In vitro transport studies confirm the strong effect of Soluplus Ò on the absorption behavior of the three tested drugs. Furthermore, the increase of drug flux across Caco-2 monolayer is correlating to the increase in plasma AUC and C max in vivo. For these poorly soluble substances Soluplus Ò has a strong potential to improve oral bioavailability. The applicability of Caco-2 monolayers as tool for predicting the in vivo transport behavior of the model drugs in combination with a solubility enhancing excipient was shown. Also the improvement of a solid dispersion compared to physical mixtures of the drugs and the excipient was correctly reflected by Caco-2 experiments. In the case of fenofibrate the possible improvement by a physical mixture was demonstrated, underscoring the value of the used tool as alternative to animal studies

FOREIGN DIRECT INVESTMENTS IN SERBIA – STATE AND PERSPECTIVES

The last decade of the twentieth century was very successful for a number of ex socialist countries of Central Europe. That was the decade of prosperity, progress, and getting closer to the modern and developed European countries. This region (Slovenia, Poland, Czech Republic, Hungary, and Slovakia) comprises group of countries in transition, which are in the front line in the process oh transformation of their economic systems, implementation of economic reforms and attracting private foreign investments, first of all, foreign direct investment. In contrast to these countries, in the area of former Yugoslavia, the early 1990s were the years of complete disintegration, marked by economic sanctions, huge human causalities, and vast destructions. The dramatic political situation Serbia was in, caused heavy consequences on its social-economic development. The result is that Serbia today is one of the least developed countries in Europe. Position of Serbian economy drastically aggravated in the area of international capital flow. In this paper we analyze one form of international capital flow that can start up the Serbian economy – foreign direct investment. In the period to come, the development of our country will mostly depend on the value of foreign investments. Without direct foreign investments and conditions of low domestic savings, limited opportunities for crediting, lack of management knowledge, modern technology and export routes, there is not going to be any economic development in Serbia. In that sense, the most prominent is the need to affirm our competitory advantages and to remove the existing limitations for foreign investments so that conditions for foreign investors to realize in the fastest way their ideas for investments are created

21 YEARS AFTER INTRODUCING SENTINEL LYMPH NODE BIOPSY IN CLINICAL PRAXIS AT THE ONCOLOGY INSTITUTE OF VOJVODINA

Introduction: Sentinel lymph node biopsy (SLNB) is a standard procedure at the OncologyInstitute of Vojvodina since 1999 and during this period we have done more than 1700 biopsies. The aim of this study was to present our results in SLNB in breast cancer surgery. Materials and methods: This retrospective study was performed at the Department for Surgical Oncology at the Vojvodina Institute of Oncology in the period from January 1999 to December 2019. The study included 1762 patients who had undergone SLNB. The mean duration of the follow-up period was 121.89 months. All patients were women with clinically T1-2N0-1M0 breast cancer. Preoperatively, all patients were administered dual contrast media, radiotracer, and blue dye. Results: The majority of tumors were T1c (955 (54.18%). The mean number of extirpated sentinel lymph nodes (SLN) in both groups was 1.84. In 199 (36.72%) patients SLN was the only metastatic lymph node in the axilla. Micro metastases were found in 113 (21.03%) patients. The overall diagnostic accuracy of SLNB was 96%. Conclusion: Axillary SLN can serve as a reliable predictor of negativity of other ipsilateral axillary nodes. Micro metastases in the SLN are not an indication for complete axillary lymph node dissection