Risk estimation for severe depressive symptoms (PHQ-2 ≥ 3).

Risk estimation for severe depressive symptoms (PHQ-2 ≥ 3).</p

Additional linear mixed model analysis for mental distress.

Additional linear mixed model analysis for mental distress.</p

Sociodemographic characteristics of the follow-up study population.

Sociodemographic characteristics of the follow-up study population.</p

Fig 2 -

Severity of mental distress of subjects with (A) and without (B) a previous diagnosis of anxiety disorder or depression by occupational SARS-CoV-2 risk group and time of survey. Mental distress is assessed using the PHQ-4 score indicating the severity of anxiety and depressive symptoms as normal (green), mild (yellow), moderate (orange) and severe (red), with missing values shown in gray. The survey was conducted during wave 1 (t1, retrospective), waves 2 and 3 (t2), wave 5 (t3, retrospective), and at the end of 2022 (t4).</p

Characterization of occupational strain in the follow-up study population.

Characterization of occupational strain in the follow-up study population.</p

Distribution of occupations at follow-up with assigned increased risk of SARS-CoV-2 infection.

Distribution of occupations at follow-up with assigned increased risk of SARS-CoV-2 infection.</p

Survey periods of the study in relation to SARS-CoV-2 incidences and pandemic waves with the respective prevailing variance of concern (VOC) in Germany.

Survey periods of the study in relation to SARS-CoV-2 incidences and pandemic waves with the respective prevailing variance of concern (VOC) in Germany.</p

Fig 1 -

Distribution of mental distress (A), probable generalized anxiety disorder (B), and probable major depressive disorder (C) by occupational SARS-CoV-2 risk group and time of survey for 260 participants with baseline and follow-up data. Mental distress is assessed using the PHQ-4 score indicating the severity of anxiety and depressive symptoms. GAD-2 scores ≥ 3 and PHQ-2 scores ≥ 3 indicate a probable generalized anxiety disorder and a probable major depressive disorder, respectively. The survey was conducted during wave 1 (t1, retrospective), waves 2 and 3 (t2), wave 5 (t3, retrospective), and at the end of 2022 (t4).</p

Risk estimation for severe anxiety symptoms (GAD-2 ≥ 3).

Risk estimation for severe anxiety symptoms (GAD-2 ≥ 3).</p

Influence of quartz exposure on lung cancer types in cases of lymph node–only silicosis and lung silicosis in German uranium miners

<p>Inhaled crystalline quartz is a carcinogen. Analyses show differences in the distribution of lung cancer types depending on the status of silicosis. Using 2,524 lung tumor cases from the WISMUT autopsy repository database, silicosis was differentiated into cases without silicosis in lung parenchyma and its lymph nodes, with lymph node–only silicosis, or with lung silicosis including lymph node silicosis. The proportions of adenocarcinoma, squamous cell carcinoma, and small-cell lung carcinoma mortality for increasing quartz exposures were estimated in a multinomial logistic regression model. The relative proportions of the lung cancer subtypes in lymph node–only silicosis were more similar to lung silicosis than without any silicosis. The results support the hypothesis that quartz-related carcinogenesis in case of lymph node–only silicosis is more similar to that in lung silicosis than in without silicosis.</p