685 research outputs found
Techniques for Consecutive TEM and Atom Probe Tomography Analysis of Nanowires
Nanowires show great promise for development in many technological applications including electronics, photonics, and displays . Due to the fine scale of nanowires, transmission electron microscopy (TEM) and atom probe tomography (APT) are among a limited number of techniques that can measure the crystallographic and chemical nature of these structures which ultimately define their performance
Techniques for Consecutive TEM and Atom Probe Tomography Analysis of Nanowires
Nanowires show great promise for development in many technological applications including electronics, photonics, and displays . Due to the fine scale of nanowires, transmission electron microscopy (TEM) and atom probe tomography (APT) are among a limited number of techniques that can measure the crystallographic and chemical nature of these structures which ultimately define their performance
The Cosmic Gamma-Ray Bursts
Cosmic gamma-ray bursts are one of the great frontiers of astrophysics today.
They are a playground of relativists and observers alike. They may teach us
about the death of stars and the birth of black holes, the physics in extreme
conditions, and help us probe star formation in the distant and obscured
universe. In this review we summarise some of the remarkable progress in this
field over the past few years. While the nature of the GRB progenitors is still
unsettled, it now appears likely that at least some bursts originate in
explosions of very massive stars, or at least occur in or near the regions of
massive star formation. The physics of the burst afterglows is reasonably well
understood, and has been tested and confirmed very well by the observations.
Bursts are found to be beamed, but with a broad range of jet opening angles;
the mean gamma-ray energies after the beaming corrections are ~ 10^51 erg.
Bursts are associated with faint ~ 25 mag) galaxies at cosmological
redshifts, with ~ 1. The host galaxies span a range of luminosities and
morphologies, but appear to be broadly typical for the normal, actively
star-forming galaxy populations at comparable redshifts and magnitudes. Some of
the challenges for the future include: the nature of the short bursts and
possibly other types of bursts and transients; use of GRBs to probe the
obscured star formation in the universe, and possibly as probes of the very
early universe; and their detection as sources of high-energy particles and
gravitational waves.Comment: An invited review, to appear in: Proc. IX Marcel Grossmann Meeting,
eds. V. Gurzadyan, R. Jantzen, and R. Ruffini, Singapore: World Scientific,
in press (2001); Latex file, 33 pages, 22 eps figures, style files include
Autoantibody detection for diagnosis in direct immunofluorescence negative mucous membrane pemphigoid: ocular and other sites compared
Objective:
To assess whether a panel of serum pemphigoid autoantibody tests could be used to confirm an immunopathological diagnosis of mucous membrane pemphigoid (MMP) in direct immunofluorescent negative (DIF-) MMP patients. /
Design:
Prospective cross-sectional study. /
Subjects and controls:
76 patients with MMP involving ocular and non-ocular sites with 45 matched controls. /
Tests:
Enzyme linked immunosorbent assays (ELISA) for BP180 and BP230 (MBL International®), IgA and IgG indirect immunofluorescence on human salt-split skin (IIF SSS) and the keratinocyte footprint assay for anti-laminin 332 antibodies. /
Main outcome measures:
Sensitivity and specificity of autoantibody detection; significant differences for individual tests and test combinations for MMP involving different sites. /
Results:
All DIF- Cases (24/76, 31.8%) had either ocular only disease or ocular involvement in multi-site disease. Serum pemphigoid autoantibodies were detected in 29/76 (38.2%) of all MMP patients compared to 3/45 (6.7%) of controls. Autoantibody reactivity detected by any one or more of the tests was present in 6/24 (25%) DIF- cases compared to 22/49 (44.9%) in DIF positive (DIF+). Compared to controls ocular only MMP serum reactivity was not significantly different for any test or test combination whereas DIF- multisite ocular MMP differed for one ELISA and 3/7 test combinations. By contrast, for DIF+ non ocular MMP all the individual tests, apart from IgA IIF, and all test combinations were significantly different compared to controls. For the whole MMP cohort the sensitivity of all tests was low having a maximum of 21.05% for BP180 reactivity, increasing to 38.16% for an optimal test combination. Disease activity was strongly associated with positive serology findings. /
Conclusions:
Pemphigoid serum autoantibody tests did not provide alternative immunopathological evidence of MMP in ocular only MMP patients but had limited value in DIF- multisite ocular MMP. The requirement for immunopathological confirmation of MMP by autoantibody detection is inappropriate for DIF- ocular only MMP resulting in missed diagnoses, delayed therapy and poor outcomes. Alternative diagnostic criteria for MMP with ocular involvement are required, to exclude the other causes of scarring conjunctivitis, until more sensitive and specific immunopathology tests become available
The results of using a tendon autograft as a new rotator cable for patients with a massive rotator cuff tear:a technical note and comparative outcome analysis
Background: Several surgical reconstructive options are available to treat massive rotator cuff tears (MRCTs). The rotator cable has an important function and we evaluated the clinical result after arthroscopic reconstruction of the rotator cable with an autograft tendon. Methods: A prospective pilot study was performed with inclusion of four patients, average age of 64 years, with an irreparable MRCT. The patients underwent an arthroscopic reconstruction of the rotator cable with the use of the long head of biceps tendon autograft, except for one which was reconstructed with a hamstring tendon. Pre- and postsurgically, the Constant-Murley Score (CMS), Western Ontario Rotator Cuff Index (WORC), Simple Shoulder Test (SST), visual analog scale (VAS) scores, and an MRI was performed. Clinical results of the study group were compared with clinical results of comparable cohort of patients with a MRCT, treated non-operatively with physiotherapy. Results: The CMS score increased after surgery in three of the four patients. The improvement of CMS score was comparable to the improvement of the CMS score encountered in a comparable cohort. The MRI at 12 months follow-up showed that the reconstructed rotator cable was disintegrated in all patients and the rotator cuff was detached and retracted. Conclusions: In our pilot study, arthroscopic reconstruction of the rotator cable using a tendon autograft failed over time and showed no clinical benefit in comparison to the non-operative treatment with physiotherapy. Trial registration: The regional Medical Ethical Committee (Zwolle) gave approval at 14th of October 2016 and assigned no. 16.06100
The afterglows of gamma-ray bursts
Gamma-ray burst astronomy has undergone a revolution in the last three years, spurred by the discovery of fading long-wavelength counterparts. We now know that at least the long-duration GRBs lie at cosmological distances with estimated electromagnetic energy release of 10^51–10^53 erg, making these the brightest explosions in the Universe. In this article we review the current observational state, beginning with the statistics of X-ray, optical, and radio afterglow detections. We then discuss the insights these observations have given to the progenitor population, the energetics of the GRB events, and the physics of the afterglow emission. We focus particular attention on the evidence linking GRBs to the explosion of massive stars. Throughout, we identify remaining puzzles and uncertainties, and emphasize promising observational tools for addressing them. The imminent launch of HETE-2 and the increasingly sophisticated and coordinated ground-based and space-based observations have primed this field for fantastic growth
The afterglows of gamma-ray bursts
Gamma-ray burst astronomy has undergone a revolution in the last three years, spurred by the discovery of fading long-wavelength counterparts. We now know that at least the long duration GRBs lie at cosmological distances with estimated electromagnetic energy release of 10^51–10^53 erg, making these the brightest explosions in the Universe. In this article we review the current observational state, beginning with the statistics of X-ray, optical, and radio afterglow detections. We then discuss the insights these observations have given to the progenitor population, the energetics of the GRB events, and the physics of the afterglow emission. We focus particular attention on the evidence linking GRBs to the explosion of massive stars. Throughout, we identify remaining puzzles and uncertainties, and emphasize promising observational tools for addressing them. The imminent launch of HETE-2 and the increasingly sophisticated and coordinated ground-based and space-based observations have primed this field for fantastic growth. This overview is a combined write-up of talks given at this conference and in NASA's Goddard Space Flight Center
The afterglows of gamma-ray bursts
Gamma-ray burst astronomy has undergone a revolution in the last three years, spurred by the discovery of fading long-wavelength counterparts. We now know that at least the long duration GRBs lie at cosmological distances with estimated electromagnetic energy release of 10^51–10^53 erg, making these the brightest explosions in the Universe. In this article we review the current observational state, beginning with the statistics of X-ray, optical, and radio afterglow detections. We then discuss the insights these observations have given to the progenitor population, the energetics of the GRB events, and the physics of the afterglow emission. We focus particular attention on the evidence linking GRBs to the explosion of massive stars. Throughout, we identify remaining puzzles and uncertainties, and emphasize promising observational tools for addressing them. The imminent launch of HETE-2 and the increasingly sophisticated and coordinated ground-based and space-based observations have primed this field for fantastic growth
GRB 000418: A Hidden Jet Revealed?
We report on optical, near-infrared and centimeter radio observations of
GRB000418 which allow us to follow the evolution of the afterglow from 2 to 200
days after the gamma-ray burst. In modeling these broad-band data, we find that
an isotropic explosion in a constant density medium is unable to simultaneously
fit both the radio and optical data. However, a jet-like outflow with an
opening angle of 10-20 degress provides a good description of the data. The
evidence in favor of a jet interpretation is based on the behavior of the radio
light curves, since the expected jet break is masked at optical wavelengths by
the light of the host galaxy. We also find evidence for extinction, presumably
arising from within the host galaxy, with A(V)=0.4 mag, and host flux densities
of F_R=1.1 uJy and F_K=1.7 uJy. These values supercede previous work on this
burst due to the availability of a broad-band data set allowing a global
fitting approach. A model in which the GRB explodes into a wind-stratified
circumburst medium cannot be ruled out by these data. However, in examining a
sample of other bursts (e.g. GRB990510, GRB000301C) we favor the jet
interpretation for GRB000418.Comment: ApJ, submitte
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