14,317 research outputs found
Ask the patients - they may want to know more than you think
What information do patients need about medicines? Partnership between health professionals and patients depends, in part, on the provision and exchange of accurate and reliable information about drugs, but who should provide it? We invited contributors to answer the question from the perspectives of patients, clinicians, and the pharmaceutical industry
People's appetite for information about their treatment is often greater than doctors believe.1 Clearly, patients vary in the extent of their desire for partnership in making medical decisions. It follows that part of the duty of a health professional is to work out how much partnership a patient wants, and what information he or she needs to support that level of partnership
The z=0.8596 Damped Lyman Alpha Absorbing Galaxy Toward PKS 0454+039
We present {\it Hubble Space Telescope} and ground--based data on the
metal line absorption system along the line of sight to PKS
0454+0356. The system is a moderate redshift damped Lyman alpha system, with
~cm as measured from the {\it
Faint Object Spectrograph} spectrum. We also present ground--based images which
we use to identify the galaxy which most probably gives rise to the damped
system; the most likely candidate is relatively underluminous by QSO absorber
standards ( for and \kms Mpc), and
lies kpc in projection from the QSO sightline. Ground--based
measurements of Zn~II, Cr~II, and Fe~II absorption lines from this system allow
us to infer abundances of [Zn/H]=, [Cr/H]=, and [Fe/H]=,
indicating overall metallicity similar to damped systems at , and that
the depletion of Cr and Fe onto dust grains may be even {\it less} important
than in many of the high redshift systems of comparable metallicity. Limits
previously placed on the 21-cm optical depth in the system, together
with our new N(H~I) measurement, suggest a very high spin temperature for the
H~I, K.Comment: changed uuencode header to produce .Z file so that unix uncompress
command will work without modifying file nam
Active and Passive Antennal Movements during Visually Guided Steering in Flying Drosophila
Insects use feedback from a variety of sensory modalities, including mechanoreceptors on their antennae, to stabilize the direction and speed of flight. Like all arthropod appendages, antennae not only supply sensory information but may also be actively positioned by control muscles. However, how flying insects move their antennae during active turns and how such movements might influence steering responses are currently unknown. Here we examined the antennal movements of flying Drosophila during visually induced turns in a tethered flight arena. In response to both rotational and translational patterns of visual motion, Drosophila actively moved their antennae in a direction opposite to that of the visual motion. We also observed two types of passive antennal movements: small tonic deflections of the antenna and rapid oscillations at wing beat frequency. These passive movements are likely the result of wing-induced airflow and increased in magnitude when the angular distance between the wing and the antenna decreased. In response to rotational visual motion, increases in passive antennal movements appear to trigger a reflex that reduces the stroke amplitude of the contralateral wing, thereby enhancing the visually induced turn. Although the active antennal movements significantly increased antennal oscillation by bringing the arista closer to the wings, it did not significantly affect the turning response in our head-fixed, tethered flies. These results are consistent with the hypothesis that flying Drosophila use mechanosensory feedback to detect changes in the wing induced airflow during visually induced turns and that this feedback plays a role in regulating the magnitude of steering responses
Using the local gyrokinetic code, GS2, to investigate global ITG modes in tokamaks. (I) s- model with profile and flow shear effects
This paper combines results from a local gyrokinetic code with analytical
theory to reconstruct the global eigenmode structure of the linearly unstable
ion-temperature-gradient (ITG) mode with adiabatic electrons. The simulations
presented here employ the s- tokamak equilibrium model. Local
gyrokinetic calculations, using GS2 have been performed over a range of radial
surfaces, x, and for ballooning phase angle, p, in the range -, to map out the complex local mode frequency, . Assuming a quadratic radial profile for the
drive, namely , (holding constant all other equilibrium
profiles such as safety factor, magnetic shear etc.), has a
stationary point. The reconstructed global mode then sits on the outboard mid
plane of the tokamak plasma, and is known as a conventional or isolated mode,
with global growth rate, ~ Max[], where
is the local growth rate. Taking the radial variation in
other equilibrium profiles (e.g safety factor q(x)) into account, removes the
stationary point in and results in a mode that peaks
slightly away from the outboard mid-plane with a reduced global growth rate.
Finally, the influence of flow shear has also been investigated through a
Doppler shift, , where n
is the toroidal mode number and incorporates the effect of
flow shear. The equilibrium profile variation introduces an asymmetry to the
growth rate spectrum with respect to the sign of ,
consistent with recent global gyrokinetic calculations.Comment: 10 pages, 8 figures and 1 tabl
Multi-camera Realtime 3D Tracking of Multiple Flying Animals
Automated tracking of animal movement allows analyses that would not
otherwise be possible by providing great quantities of data. The additional
capability of tracking in realtime - with minimal latency - opens up the
experimental possibility of manipulating sensory feedback, thus allowing
detailed explorations of the neural basis for control of behavior. Here we
describe a new system capable of tracking the position and body orientation of
animals such as flies and birds. The system operates with less than 40 msec
latency and can track multiple animals simultaneously. To achieve these
results, a multi target tracking algorithm was developed based on the Extended
Kalman Filter and the Nearest Neighbor Standard Filter data association
algorithm. In one implementation, an eleven camera system is capable of
tracking three flies simultaneously at 60 frames per second using a gigabit
network of nine standard Intel Pentium 4 and Core 2 Duo computers. This
manuscript presents the rationale and details of the algorithms employed and
shows three implementations of the system. An experiment was performed using
the tracking system to measure the effect of visual contrast on the flight
speed of Drosophila melanogaster. At low contrasts, speed is more variable and
faster on average than at high contrasts. Thus, the system is already a useful
tool to study the neurobiology and behavior of freely flying animals. If
combined with other techniques, such as `virtual reality'-type computer
graphics or genetic manipulation, the tracking system would offer a powerful
new way to investigate the biology of flying animals.Comment: pdfTeX using libpoppler 3.141592-1.40.3-2.2 (Web2C 7.5.6), 18 pages
with 9 figure
Structure of Micro-instabilities in Tokamak Plasmas: Stiff Transport or Plasma Eruptions?
Solutions to a model 2D eigenmode equation describing micro-instabilities in
tokamak plasmas are presented that demonstrate a sensitivity of the mode
structure and stability to plasma profiles. In narrow regions of parameter
space, with special plasma profiles, a maximally unstable mode is found that
balloons on the outboard side of the tokamak. This corresponds to the
conventional picture of a ballooning mode. However, for most profiles this mode
cannot exist and instead a more stable mode is found that balloons closer to
the top or bottom of the plasma. Good quantitative agreement with a 1D
ballooning analysis is found provided the constraints associated with higher
order profile effects, often neglected, are taken into account. A sudden
transition from this general mode to the more unstable ballooning mode can
occur for a critical flow shear, providing a candidate model for why some
experiments observe small plasma eruptions (Edge Localised Modes, or ELMs) in
place of large Type I ELMs.Comment: 11 pages, 3 figure
Visual control of flight speed in Drosophila melanogaster
Flight control in insects depends on self-induced image motion (optic flow), which the visual system must process to generate appropriate corrective steering maneuvers. Classic experiments in tethered insects applied rigorous system identification techniques for the analysis of turning reactions in the presence of rotating pattern stimuli delivered in open-loop. However, the functional relevance of these measurements for visual free-flight control remains equivocal due to the largely unknown effects of the highly constrained experimental conditions. To perform a systems analysis of the visual flight speed response under free-flight conditions, we implemented a `one-parameter open-loop' paradigm using `TrackFly' in a wind tunnel equipped with real-time tracking and virtual reality display technology. Upwind flying flies were stimulated with sine gratings of varying temporal and spatial frequencies, and the resulting speed responses were measured from the resulting flight speed reactions. To control flight speed, the visual system of the fruit fly extracts linear pattern velocity robustly over a broad range of spatio–temporal frequencies. The speed signal is used for a proportional control of flight speed within locomotor limits. The extraction of pattern velocity over a broad spatio–temporal frequency range may require more sophisticated motion processing mechanisms than those identified in flies so far. In Drosophila, the neuromotor pathways underlying flight speed control may be suitably explored by applying advanced genetic techniques, for which our data can serve as a baseline. Finally, the high-level control principles identified in the fly can be meaningfully transferred into a robotic context, such as for the robust and efficient control of autonomous flying micro air vehicles
The Meaning of Nationality in the Recent Immigration Acts
Professor Dickinson\u27s commentary on the quotas involved in the Immigration Act of 1921 and of 1924. Until the more recent enactment the meaning of nationality was obscured in a curious ambiguity ... the Act of 1921 made nationality the basis of the quote plan....
Whether nationality was used in the scientific sense, however, meaning the character created by allegiance to a recognized nation or state, or whether its significance was arbitrary, referring only to such groupings as might be arranged by census makers or other such administrative officials, remained to be determined by judicial construction.
Professor Dickinson then narrates how this created an intolerable situation amended by the Immigration Act of 1924
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