Craniocerebral vegetal foreign body granuloma: a case report and review of literature

Objective Craniocerebral vegetal foreign body granuloma is rare lesion which is very difficult to diagnose clinically, and is easy to be misdiagnosed. This article aims to reveal the clinical manifestations and histopathological features of it. Methods A case of cerebral vegetal foreign body granuloma was reported focusing on the following aspects: clinical manifestations, histopathological features and immunophenotype and the relevant literature was reviewed. Results A 23-year-old male patient presented with paroxysmal stiffness accompanied by convulsion of extremities and no response for calling for 7 years. Cranial MRI scan demonstrated a small nodular mixed signal shadow about 1.60 cm in length located in the frontal cortex under the anterior horn of the left compartment with gliosis near frontal lobe. A resection was performed, and a lesion (about 3 cm × 2 cm) was found in the bottom of the left frontal lobe. The lesion was greyish brown, tenacious, irregular bordered, partly calcified and with rich blood supply. There was no tumor or parasite but proliferation of fibrous tissue, hyaline degeneration, calcification, infiltration of lymphocytes and plasma cells in the granuloma lesion under microscope. The immunohistochemical staining showed the lesion was positive for vimentin (Vim) and CD68, while negative for glial fibrillary acidic protein (GFAP), S⁃100 protein (S-100) and epithelial membrane antigen (EMA). Conclusion Clinical manifestations of craniocerebral vegetal foreign body granuloma are various according to the occurrence in different parts. Besides, its imaging features are various depending on the kind of foreign body and the persistent duration. However, histopathological observation and immunohistochemical staining facilitate its diagnosis and identification from tumor and parasitic disease. Furthermore, the type of plant can also be distinguished roughly. <br /

Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients.

BACKGROUND:Aberrant Rad51 expression is implicated in the progression of human malignancies. However, the role of Rad51 in colorectal cancer (CRC) remains undefined. This study aimed to establish a relationship between Rad51 and clinicopathologic features of CRC. METHODS:We retrospectively examined the paraffin-embedded tissue samples obtained from 54 patients with CRC who had received surgical therapies at our institution during 2006-2008. Rad51 expression in adenocarcinoma, paracancerous tissue, and normal colonic tissue was determined by immunohistochemistry. The correlation between Rad51 immunoreactivity and clinicopathologic features of these patients was evaluated. RESULTS:Rad51 immunoreactivity was detected in 67% of adenocarcinoma, 48% of paracancerous tissue, and 27% of normal colonic mucosa. Rad51 expression in adenocarcinoma was significantly higher than normal colonic tissue (p < 0.05). Rad51 was also overexpressed in poorly differentiated tumors and tumor samples from patients with lymph node metastasis (p < 0.05). Patients with Rad51 overexpression had a 69% two-year survival, 49% three-year survival, and 16% five-year survival, considerably worse than patients with negative Rad51 expression (p < 0.05). CONCLUSION:Our data suggest that Rad51 overexpression is correlated with malignant phenotypes of CRC and may predict poor prognosis for these patients

Easily misdiagnosed metaplastic meningioma: one case report and review of literature

<p><strong>Objective</strong> Metaplastic meningioma is rare lesion which is very difficult to diagnose clinically, and is easy to be misdiagnosed. This article aims to reveal the clinical manifestations and histopathological features of this disease.  <strong>Methods</strong> One case of ossification metaplastic meningioma was reported and the relevant literatures were reviewed.  <strong>Results</strong> A 17-year-old female patient showed paroxysmal stiffness accompanied by convulsion of extremities, headache, vomiting and fever. Cranial CT scan demonstrated an irregular low-density signal in the right frontal and parietal lobes. The lesion did not have a clear boundary, and there was a calcificated high-density signal inside it. The size of the lesion was about 2 cm × 1.80 cm × 1.70 cm. Cranial MRI scan showed a tumor with size of 2.40 cm × 2.10 cm × 2 cm, located in the right frontal and parietal lobes, and there was large edema around the lesion. A resection was performed, and a lesion was found in the right frontal and parietal parenchyma, whose one side was close to the cerebral pia mater and did not invade into the dura and the skull. The tumor was yellow, in irregular shape, and had clear boundary, with hard texture and rich blood supply. Its size was about 3 cm × 2.50 cm × 2 cm. There was extensive ossification and calcification within the tumor under microscope. Tumor cells were flaky and like small nests, which were distributed in the mesh?like arranged trabecular bone. The immunohistochemical staining showed that epithelial membrane antigen (EMA), progesterone receptor (PR), vimentin (Vim) and Bcl-2 were positive for tumor cells with Ki-67 labeling index being about 6%.  <strong>Conclusions</strong> Metaplastic meningioma has various metaplastic components and its imaging features are also various. However, it could be diagnosed and identified from other similar tumors by histopathological observation and immunohistochemical staining.</p><p> </p><p>doi: 10.3969/j.issn.1672-6731.2014.08.010</p

Kaplan-Meier survival analysis of CRC patients with or without Rad51 overexpression.

<p>The survival rate for patients with Rad51 overexpression was significantly lower than those without Rad51 amplification.</p

Rad51 expression in adenocarcinoma, paracancerous and normal colonic tissue.

<p>Rad51 expression in adenocarcinoma was statistically higher than in the normal colonic tissue. * p < 0.001.</p

Correlation of Rad51 expression with clinicopathological characteristics.

<p>Correlation of Rad51 expression with clinicopathological characteristics.</p

Predictors for Depression, Sleep Disturbance, and Subjective Pain among Inpatients with Depressive Disorders during the COVID-19 Pandemic: A Cross-Sectional Study

The coronavirus disease 2019 (COVID-19) pandemic can have a negative impact on patients with mood disorders. The aim of this study is to explore the societal influence of COVID-19 and associated impacts on levels of depression, sleep disturbance, and subjective pain among patients with mood disorders. This cross-sectional study recruited inpatients with depression and bipolar disorder. Levels of depression, sleep disturbance, subjective pain, and related demographic variables were collected through self-reported questionnaires. Potential factors associated with levels of depression, sleep disturbance, and subjective pain were identified using univariate linear regression and further entered into a stepwise multivariate linear regression model to identify the independent predictors. A total of 119 participants were included in the analysis, of whom 50.42% had bipolar disorder and 49.58% had unipolar depression. Multivariate analysis showed that a higher level of depression was associated with female subjects, subjects with partners, present history of psychological trauma, and drinking alcohol. Sleep disturbance was associated with subjects with partners and drinking alcohol. A higher level of subjective pain was associated with a higher level of social anxiety and a history of psychological trauma. The current study identified several predictors of psychological burden and subjective pain among inpatients with depression during the COVID-19 pandemic. Further investigations are warranted to extend the application and generalizability of our results

Immunohistochemical analysis of Rad51 expression in CRC tissues.

<p>(<b>A)</b> Rad51 was overexpressed in a poorly differentiated CRC. Cells with positive Rad51 expression showed yellow, buffy and brown granules in the nuclei. (<b>B)</b> Rad51 staining was negative in a well differentiated CRC. (<b>C)</b> H&E staining of a poorly differentiated CRC. (<b>D)</b> H&E staining of a well differentiated CRC. Representative images with original magnification at 200X. <b>(E)</b> Quantitation of Rad51 expression in poorly differentiated versus well differentiated tumors. * p = 0.006.</p