1 research outputs found
Effect of Nanoparticle Stabilization and Physicochemical Properties on Exposure Outcome: Acute Toxicity of Silver Nanoparticle Preparations in Zebrafish (<i>Danio rerio</i>)
Nanotechnology has
vast potential for expanded development and
novel application in numerous sectors of society. With growing use
and applications, substantial production volumes and associated environmental
release can be anticipated. Exposure effect of nanoparticles (NP)
on biological systems may be intrinsic to their physicochemical properties
introducing unknown associated risk. Herein, we expand the knowledge
of health and environmental impact of silver nanoparticles (AgNPs),
testing the acute toxicity of 14 AgNP preparations on developing zebrafish
embryos (<i>Danio rerio</i>). Toxicological end points,
including mortality, hatching rate, and heart rate were recorded.
Concentration, stabilization agent and physicochemical properties
were monitored as contributing outcome factors. Our findings indicate
wide ranging LC<sub>50</sub> 24 h postfertilization values (0.487
ppm (0.315, 0.744 95% CI) to 47.89 ppm (18.45, 203.49 95% CI)), and
indicate surface charge and ionic dissolution as key contributory
factors in AgNP exposure outcome