Developmental exposure to low-dose of bisphenol A alters maternal behaviour in rats

article présenté lors du 47. Congress of the European-Societies-of-Toxicology ; Paris (France) - (2011-08-28 - 2011-08-31) / CongrèsInternational audienceMaternal behaviour is a biomarker of neurotoxicity that is used. in the safety evaluation of chemical substances. The objective of. this study was to determine the effects on the F0 and F1 maternal. behaviour of gestation/lactation exposure of Wistar rats dams. (F0) with a low dose of bisphenol A consistent with human exposure. BisphenolAwas administered daily to pregnant rats by gavage. (5 g/kg body weight) from the first day of gestation (G1) to weaning. (PND 21) and then to the female offspring’s until their mating. at the adulthood (F1). For each generation, assessments of maternal. behaviour were carried out within two hours of the beginning. of the light cycle from the parturition to PND 8 by observing. presence/absence of the following behaviours: Nursing (Arched,. blanket and passive position); Resting (Inside the nest or outside. the nest); Anogenital licking; Self grooming; Pup licking; Pup carrying;. Feeding; Drinking; Exploration; Rearing; Nest building. We. show a significant decrease in the percentage of dams nursing, resting. inside the nest, nest building, and pup carrying in both BPA. treated mothers F0 and their F1 offspring (p < 0.05). Nevertheless,. there was no significant interaction between BPA treatment, generation. and percentage of dams observed drinking, feeding, self. grooming, exploring, anogenital and pup licking or rearing. The. present findings indicate that both an early exposure (F1) and an. adult exposure (F0) to a low-dose of BPA lead to significant effect. on maternal behaviour

Effets trans-générationnel du Bisphénol A sur le comportement et le développement chez le rat

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Effets trans-générationnel des xéno-hormones sur le comportement et le développement chez le rat

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Tran generational effects of xeno-hormones mixtures on development and behaviour in rats

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Effects of BPA and Endocrine Disruptor Mixtures on development and taste preferences in the non-exposed F2 offspring Wistar rats. CIME project

Effects of BPA and Endocrine Disruptor Mixtures on development and taste preferences in the non-exposed F2 offspring Wistar rats. CIME project. Colloque PNR-P

Bisphenol A from drinking water affects taste preferences and oral homeostasis in male rat

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Multigenerational effects of BPA aloneor in combination with genistein and/or vinclozolin on maternal behavior in wistar rats

Poster présenté lors du colloque.Multigenerational effects of BPA aloneor in combination with genistein and/or vinclozolin on maternal behavior in wistar rats. colloque de la DOHAD, section toxicology and environmental pollutant

A multi-generational study on low-dose BPA exposure in Wistar rats: Effects on maternal behavior, flavor intake and development

Bisphenol A (BPA) is a common endocrine disruptor found as an environmental and food contaminant. It exerts both developmental and behavioral effects, mainly when exposure occurs in early life. The aim of this study was to determine the multi-generational effects of chronic, human-relevant low-dose exposure to BPA on development, maternal behavior and flavor preference in Wistar rats. BPA was orally administered at a daily dose of 5 mu g/kg body weight to FO pregnant dams from the first day of gestation (GD 1) until the last day of lactation (LD 21), and then to Fl offspring from weaning (PND 21) to adulthood (PND 100). F2 offspring were not exposed. Development and clinical signs of toxicity were assessed daily. Maternal behavior was evaluated by observing nursing and pup-caring actions, as well as "non-maternal" behaviors in FO and Fl dams from parturition until LD 8. The flavor preferences of Fl and F2 offspring were evaluated based on the intake of sweet, salt and fat solutions using the two-bottle choice test on PND 21-34 and PND 86-99. BPA exposure: 1) decreased maternal behavior in Fl dams, 2) caused developmental defects in both Fl and F2 offspring, with a noticeable decrease in anogenital distance in male rats, and 3) did not affect flavored solution intake in Fl, but induced changes in sweet preference in F2 juveniles and in salt and fat solution intakes in F2 adults, and 4) induced a body weight increase in the F2 generation only, whereas food intake and water consumption did not change. Taken as a whole, our findings showed that both gestational (F0) and lifelong (F1) exposures to a human-relevant dose of BPA could induce multi-generational effects on both development and behavior. These results suggest possible selective neuroendocrine defects and/or epigenetic changes caused by BPA exposure. (c) 2013 Elsevier Inc. All rights reserved

Are taste preferences related to submandibular endocrine or exocrine secretions? A rodent study

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High fat-high fructose diet triggered metabolic syndrome and retinal neovascular complications in the rat

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