A decision-making approach for investigating the potential effects of near sourcing on supply chain

Purpose - Near sourcing is starting to be regarded as a valid alternative to global sourcing in order to leverage supply chain (SC) responsiveness and economic efficiency. The present work proposes a decision-making approach developed in collaboration with a leading Italian retailer that was willing to turn the global store furniture procurement process into near sourcing. Design/methodology/approach - Action research is employed. The limitations of the traditional SC organisation and purchasing process of the company are first identified. On such basis, an inventory management model is applied to run spreadsheet estimates where different purchasing and SC management strategies are adopted to determine the solution providing the lowest cost performance. Finally, a risk analysis of the selected best SC arrangement is conducted and results are discussed. Findings - Switching from East Asian suppliers to continental vendors enables a SC reengineering that increases flexibility and responsiveness to demand uncertainty which, together with decreased transportation costs, assures economic viability, thus proving the benefits of near sourcing. Research limitations/implications - The decision-making framework provides a methodological roadmap to address the comparison between near and global sourcing policies and to calculate the savings of the former against the latter. The approach could include additional organisational aspects and cost categories impacting on near sourcing and could be adapted to investigate different products, services, and business sectors. Originality/value - The work provides SC researchers and practitioners with a structured approach for understanding what drives companies to adopt near sourcing and for quantitatively assessing its advantage

Changes in protein expression in two cholangiocarcinoma cell lines undergoing formation of multicellular tumor spheroids In vitro

Epithelial-to-Mesenchymal Transition (EMT) is relevant in malignant growth and frequently correlates with worsening disease progression due to its implications in metastases and re- sistance to therapeutic interventions. Although EMT is known to occur in several types of solid tumors, the information concerning tumors arising from the epithelia of the bile tract is still limited. In order to approach the problem of EMT in cholangiocarcinoma, we decided to investigate the changes in protein expression occurring in two cell lines under conditions leading to growth as adherent monolayers or to formation of multicellular tumor spheroids (MCTS), which are considered culture models that better mimic the growth characteristics of in-vivo solid tumors. In our system, changes in phenotypes occur with only a decrease in transmembrane E-cadherin and vimentin expression, minor changes in the transglutami- nase protein/activity but with significant differences in the proteome profiles, with declining and increasing expression in 6 and in 16 proteins identified by mass spectrometry. The aris- ing protein patterns were analyzed based on canonical pathways and network analysis. These results suggest that significant metabolic rearrangements occur during the conver- sion of cholangiocarcinomas cells to the MCTS phenotype, which most likely affect the car- bohydrate metabolism, protein folding, cytoskeletal activity, and tissue sensitivity to oxygen

Sustainable choice of the location of a biomass plant: an application in Tuscany

The management of complex systems often requires taking decisions that may affect the company's future. Making decisions is not easy and requires you to take serious responsibility. The company character appointed to this task, is the “decision-makers” who, within a job or project, must make a selection among several alternatives. To carry out this task, you must perform a process called "decision analysis". It can be aided by qualitative and quantitative tools, able to rationalize a multifactorial choice and bring it to a judgment of performance parameters more easily comparable. In fact, if this problem is addressed considering only the economic aspects, other fundamental parameters will be neglected such as, for example, the environmental ones. Actually, bringing many different aspects to a simple economic performance, or anyway one-dimensional, proves to be a limiting and unsatisfactory approach. In addition, if we consider the concepts of sustainability, we should at least take into account the three dimensions that describe it, namely the economic, environmental and social issues. Then, a strategy of decision making more complete that could integrate all the three aspects, becomes much more appropriate. In this context, the multi-criteria analysis are particularly suitable for this purpose. In this study we aim at investigating how one of the most popular multi-criteria methods, the Analytic Network Process (ANP) can be used to define the location of a cogeneration plant fuelled by biomass. The novelty of this study consists of having categorized and divided into homogeneous areas an entire region. In addition, to evaluate the economic efficiency, as compared to other authoritative work on the subject, also the water content in the raw material was considered, influencing the amount of biomass consumed. The results show that the ANP allows decisions making according to an overall view, considering a wide variety of parameters and allows the decision makers to better represent the needs of the stakeholder

Confocal laser scanning microscope, raman microscopy and western blotting to evaluate inflammatory response after myocardial infarction

Cardiac muscle necrosis is associated with inflammatory cascade that clears the infarct from dead cells and matrix debris, and then replaces the damaged tissue with scar, through three overlapping phases: the inflammatory phase, the proliferative phase and the maturation phase. Western blotting, laser confocal microscopy, Raman microscopy are valuable tools for studying the inflammatory response following myocardial infarction both humoral and cellular phase, allowing the identification and semiquantitative analysis of proteins produced during the inflammatory cascade activation and the topographical distribution and expression of proteins and cells involved in myocardial inflammation. Confocal laser scanning microscopy (CLSM) is a relatively new technique for microscopic imaging, that allows greater resolution, optical sectioning of the sample and three-dimensional reconstruction of the same sample. Western blotting used to detect the presence of a specific protein with antibody-antigen interaction in the midst of a complex protein mixture extracted from cells, produced semi-quantitative data quite easy to interpret. Confocal Raman microscopy combines the three-dimensional optical resolution of confocal microscopy and the sensitivity to molecular vibrations, which characterizes Raman spectroscopy. The combined use of western blotting and confocal microscope allows detecting the presence of proteins in the sample and trying to observe the exact location within the tissue, or the topographical distribution of the same. Once demonstrated the presence of proteins (cytokines, chemokines, etc.) is important to know the topographical distribution, obtaining in this way additional information regarding the extension of the inflammatory process in function of the time stayed from the time of myocardial infarction. These methods may be useful to study and define the expression of a wide range of inflammatory mediators at several different timepoints providing a more detailed analysis of the time course of the infarct

Analytical probabilistic approach to the ground state of lattice quantum systems: exact results in terms of a cumulant expansion

We present a large deviation analysis of a recently proposed probabilistic approach to the study of the ground-state properties of lattice quantum systems. The ground-state energy, as well as the correlation functions in the ground state, are exactly determined as a series expansion in the cumulants of the multiplicities of the potential and hopping energies assumed by the system during its long-time evolution. Once these cumulants are known, even at a finite order, our approach provides the ground state analytically as a function of the Hamiltonian parameters. A scenario of possible applications of this analyticity property is discussed.Comment: 26 pages, 5 figure

Attenuation of choroidal tickness in patients with Alzheimer disease: evidence from an Italian prospective study

INTRODUCTION: To compare the 12-month choroidal thickness (CT) change between Alzheimer disease (AD) patients and normal subjects. METHODS: In this prospective, observational study, 39 patients with a diagnosis of mild to moderate AD and 39 age-matched control subjects were included. All the subjects underwent neuropsychological (Mini Mental State Examination, Alzheimer disease Assessment Scale-Cognitive Subscale, and the Clinical Dementia Rating Scale) and ophthalmological evaluation, including spectral domain optical coherence tomography, at baseline and after 12 months. CT was measured manually using the caliper tool of the optical coherence tomography device. RESULTS: After 12 months, AD patients had a greater reduction of CT than controls (P≤0.05, adjusted for baseline CT, age, sex, axial length, and smoking). DISCUSSION: CT in patients with AD showed a rate of thinning greater than what could be expected during the natural course of aging

The effects of customer-centricity in hospitality

Hospitality is a field in which guests’ specific needs and wants should always be given serious consideration by hoteliers. Putting the guest at the centre of all business efforts contributes to generating customer value and enhancing a firm's competitiveness. Being customer-centric is paramount for hospitality establishments to create and sustain superior customer value. However, there is scant evidence in hospitality marketing literature of a clear understanding of the customer-centricity concept or of the possible effects of its implementation. Using a mixed-methods multiple case study approach, this research studies two different properties that, to some extent, are already engaged in customer-centricity practices through the use of advanced Customer Relationship Manager software. Results clearly show an increase in customer ratings, leading to possible profit implications; a cultural shift within the organizations studied connected with the customer-centricity phenomenon has also been reported

Fluid dynamics, sediment transport and mixing about the confluence of Negro and Solimões rivers, Manaus, Brazil

As part of a project to investigate the hydrodynamic, sediment transport and mixing processes about the large confluences of the Amazon River, a field study was conducted about the confluence of the Negro and Solimões Rivers. This confluence ranks among the largest confluences on Earth the outcomes of this study may also provide some general insights into large confluence dynamics. A detailed series of ADCP, water quality and seismic profile measurements were collected to investigate key hydrodynamic and morphodynamic features about this confluence. Presented here are the key hydrodynamic features observed about this large confluence and how these relate to findings in previous studies conducted in flumes and small confluences. Finally some insights into how the differences in water characteristics and the hydrodynamics of these two rivers may influence the rate of mixing downstream are presented