Note On Endomorphism Algebras Of Separable Monoidal Functors

We recall the Tannaka construction for certain types of split monoidal functor into Vect_{k}, and remove the compactness restriction on the domain

Carbonate Formation in Non-Aqueous Environments by Solid-Gas Carbonation of Silicates

We have produced synthetic analogues of cosmic silicates using the Sol Gel method, producing amorphous silicates of composition Mg(x)Ca(1-x)SiO3. Using synchrotron X-ray powder diffraction on Beamline I11 at the Diamond Light Source, together with a newly-commissioned gas cell, real-time powder diffraction scans have been taken of a range of silicates exposed to CO2 under non-ambient conditions. The SXPD is complemented by other techniques including Raman and Infrared Spectroscopy and SEM imaging.Comment: 5 pages, 3 figures. Contribution to the Proceedings of the First European Conference on Laboratory Astrophysics (ECLA

Immunohistochemistry in Irradiated Skin Tissue

Currently there is no effective treatment for radiation dermatitis that results from clinical or accidental radiation exposures. Radiation exposure can cause severe burns and sloughing of the skin and damage muscle and bone layers underneath the skin. Radiation exposure in cells results in several types of cell death, such as necrosis, apoptosis, or autophagy, or accelerated senescence. Preliminary experiments demonstrated that accelerated senescence is a primary response to radiation in normal skin cells in culture and skin tissue in vivo in mice. We wanted to use immunohistochemistry to identify the skin cells that undergo senescence in tissues obtained from 4 mice over a time course from 1-30 days following exposure to 17.9 Gy (0.6 Gy/min) irradiation. The different stains that are going to be used are hematoxylin and eosin stain which shows the morphology of the whole tissue, K15 which marks adult skin epidermal stem cells, p21/waf1 which is a marker for senescence, DCT which marks melanocyte stem cells, and c-kit which marks melanocytes and basal epithelial cells. The results from these experiments will help us to determine which cells to protect in order to treat severe radiation exposure

San Marco D/L solar array system design and performance

The design and performance of the solar array system for the San Marco D/L spacecraft is described in detail. The solar array system design is shown to be suitable for spacecraft which have elastically sensitized outer surfaces to measure aerodynamic forces. However, the performance of this solar array system is shown to be at least 30 percent less efficient than conventional spacecraft solar array designs. An on-board experiment to compare the in-flight performances of Si and GaAs solar cell panels is also described. Preflight performance data show that at beginning-of-life, air mass zero solar illumination, 28 C and peak power output the Si panels are at last 20 percent less efficient than the GaAs panels

Pulse-like and crack-like ruptures in experiments mimicking crustal earthquakes

Theoretical studies have shown that the issue of rupture modes has important implications for fault constitutive laws, stress conditions on faults, energy partition and heat generation during earthquakes, scaling laws, and spatiotemporal complexity of fault slip. Early theoretical models treated earthquakes as crack-like ruptures, but seismic inversions indicate that earthquake ruptures may propagate in a self-healing pulse-like mode. A number of explanations for the existence of slip pulses have been proposed and continue to be vigorously debated. This study presents experimental observations of spontaneous pulse-like ruptures in a homogeneous linear-elastic setting that mimics crustal earthquakes; reveals how different rupture modes are selected based on the level of fault prestress; demonstrates that both rupture modes can transition to supershear speeds; and advocates, based on comparison with theoretical studies, the importance of velocity-weakening friction for earthquake dynamics

Summary of Voyager Design and Flight Loads

Estimates of flight loads for Voyager 1 and Voyager 2 are summarized and compared to the Voyager design loads obtained from the shock spectra/impedance method and to the loads obtained using space vehicle transient loads analysis. These estimates were obtained by using the measured flight accelerations at the launch vehicle/spacecraft interface as forcing functions for the Voyager mathematical model. Based on these data, an assessment of the shock spectra/impedance loads method used for Voyager is presented. The following conclusions were reached: (1) the shock spectra approach provided reasonable conservative design loads for Voyager, (2) care has to be executed to insure that all critical events are accounted for in constructing shock spectra envelopes, (3) the selection of critical events is not always obvious, especially for those flight events wherein the spacecraft dynamic characteristics are important, and (4) the success of the method is strongly dependent on the analysts' experience and judgement

Flucytosine and cryptococcosis: time to urgently address the worldwide accessibility of a 50-year-old antifungal.

Current, widely accepted guidelines for the management of HIV-associated cryptococcal meningoencephalitis (CM) recommend amphotericin B combined with flucytosine (5-FC) for ≥2 weeks as the initial induction treatment of choice. However, access to flucytosine in Africa and Asia, where disease burden is greatest, is inadequate at present. While research into identifying effective and well-tolerated antifungal combinations that do not contain flucytosine continues, an ever-increasing body of evidence from in vitro, in vivo and clinical studies points to the benefits of flucytosine in the treatment of CM in both intravenous combinations with amphotericin B and oral combinations with high-dose fluconazole. This article provides an up-to-date review of this evidence, and the current issues and challenges regarding increasing access to this key component of combination antifungal therapy for cryptococcosis

Electrospray synthesis of PLGA TIPS microspheres

We successfully demonstrate the synthesis of polymer microspheres using a single electrospray source, and show their physical characterisation. Electrospray has proven to be a versatile method to manufacture particles, giving tight control over size with quasi-monodisperse size distributions. It is a liquid atomisation technique that generates a monodisperse population of highly charged liquid droplets over a broad size range (nanometres to tens of microns). The droplets contain liquid precursors for the in-flight synthesis of particles, and control over the trajectory of these droplets can be precisely manipulated with the use of electric fields to drive them to a grounded substrate. This study reports a method to synthesize poly(lactic-co-glycolic) acid (PLGA) microspheres using the electrospray and thermally induced phase separation (TIPS) techniques, followed by subsequent freeze-drying, for particle production. These microspheres are of interest as vehicles for controlled drug release systems