Blooming Moth Dress

Original draped dress design using original digitally-printed fabric design

Circular RNAs: New layer of complexity evading breast cancer heterogeneity

© 2022 The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY), https://creativecommons.org/licenses/by/4.0/Advances in high-throughput sequencing techniques and bioinformatic analysis have refuted the "junk" RNA hypothesis that was claimed against non-coding RNAs (ncRNAs). Circular RNAs (circRNAs); a class of single-stranded covalently closed loop RNA molecules have recently emerged as stable epigenetic regulators. Although the exact regulatory role of circRNAs is still to be clarified, it has been proven that circRNAs could exert their functions by interacting with other ncRNAs or proteins in their own physiologically authentic environment, regulating multiple cellular signaling pathways and other classes of ncRNAs. CircRNAs have also been reported to exhibit a tissue-specific expression and have been associated with the malignant transformation process of several hematological and solid malignancies. Along this line of reasoning, this review aims to highlight the importance of circRNAs in Breast Cancer (BC), which is ranked as the most prevalent malignancy among females. Notwithstanding the substantial efforts to develop a suitable anticancer therapeutic regimen against the heterogenous BC, inter- and intra-tumoral heterogeneity have resulted in an arduous challenge for drug development research, which in turn necessitates the investigation of other markers to be therapeutically targeted. Herein, the potential of circRNAs as possible diagnostic and prognostic biomarkers have been highlighted together with their possible application as novel therapeutic targets.Peer reviewe

Djelotvornost ivermektina kao injekcijske otopine protiv želučano-crijevnih oblića magaraca (Equus asinus).

The efficacy of Ivermectin was evaluated under field conditions at Nyala town, South Darfur State, Sudan. The study involved 16 donkeys. Ivermectin was administered by intramuscular injection at dose of 0.2 mg/kg in the lateral mid- line of the neck. Treatment efficacy was based on the mean faecal egg count reduction 14 days post treatment. A faecal egg count reduction of 100% was found after treatment with Ivermectin. In addition efficacy percentages of Ivermectin against immature and adult nematodes were as follows: Trichostrongylus axei 100%, Parascaris equorum 100%, Oxyuris equi 100%, Triodontophorus sp. 100%, Strongylus sp. 100%, and small strongyles 100%. Two of the control donkeys were infected with Strongylus vulgaris larvae. Ivermectin showed moderate efficacy (69.23%) against larvae found in the mesenteric artery aneurisms. No adverse reactions were observed during the experimental period.Procjenjivana je djelotvornost ivermektina u terenskim uvjetima u gradu Nyala, Južni Darfur, Sudan. Istraživanje je provedeno na 16 magaraca. Ivermektin je bio primijenjen intramuskularnim injekcijama u dozi od 0,2 mg/kg u lateralnu stranu vrata. Ocjena učinkovitosti lijeka provedena je na temelju smanjenja ukupnog broja jaja u fecesu 14 dana poslije liječenja. Ukupni broj jaja u fecesu smanjio se za 100% poslije primjene ivermektina. Nadalje, postotci djelotvornosti ivermektina protiv nezrelih i adultnih stadija oblića bili su: Trichostrongylus axei 100%, Parascaris equorum 100%, Oxyuris equi 100%, Triodontophorus sp. 100%, Strongylus sp. 100% i mali strongilidi 100%. Dva kontrolna magarca bila su invadirana ličinkama Strongylus vulgaris. Ivermektin je bio umjereno djelotvoran (69,23%) protiv ličinki nađenih u aneurizmama mezenterijalnih arterija. Tijekom pokusa nisu zamijećene štetne posljedice liječenja

Blooming Moth Dress

Original draped dress design using original digitally-printed fabric design.</p

Global economic burden of unmet surgical need for appendicitis

Background There is a substantial gap in provision of adequate surgical care in many low- and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US $92 492 million using approach 1 and$73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was $95 004 million using approach 1 and$75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially

Global economic burden of unmet surgical need for appendicitis

Background There is a substantial gap in provision of adequate surgical care in many low- and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US $92 492 million using approach 1 and$73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was $95 004 million using approach 1 and$75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially