508 research outputs found
Reentrant behavior of superconducting alloys
A dirty BCS superconductor with magnetic impurities is studied. Asymptotic
solution of the thermodynamics of such superconductor with spin and
magnetic impurities, is found. To this end, the system's free energy is bounded from above and below by mean-field type bounds, which are
shown to coalesce almost exactly in the thermodynamic limit, provided the
impurity concentration is sufficiently small. The resulting mean-field
equations for the gap and a parameter , characterizing the
impurity subsystem, are solved and the solution minimizing is found for
various values of magnetic coupling constant and impurity concentration
. The phase diagrams of the system are depicted with five distinct phases:
the normal phase, unperturbed superconducting phase, perturbed superconducting
phase with nonzero gap in the excitation spectrum, perturbed gapless
superconducting phase and impurity phase with completely suppressed
superconductivity. Furthermore, evidence of reentrant superconductivity and
Jaccarino-Peter compensation is found. The credibility of the theory is
verified by testing the dependence of the superconducting transition
temperature on . Very good quantitative agreement with
experimental data is obtained for several alloys: (LaCe)Al,
(LaGd)Al and (LaY)Ce. The theory
presented improves earlier developments in this field.Comment: 15 pages, 8 figures, full length articl
Nonparametric Information Geometry
The differential-geometric structure of the set of positive densities on a
given measure space has raised the interest of many mathematicians after the
discovery by C.R. Rao of the geometric meaning of the Fisher information. Most
of the research is focused on parametric statistical models. In series of
papers by author and coworkers a particular version of the nonparametric case
has been discussed. It consists of a minimalistic structure modeled according
the theory of exponential families: given a reference density other densities
are represented by the centered log likelihood which is an element of an Orlicz
space. This mappings give a system of charts of a Banach manifold. It has been
observed that, while the construction is natural, the practical applicability
is limited by the technical difficulty to deal with such a class of Banach
spaces. It has been suggested recently to replace the exponential function with
other functions with similar behavior but polynomial growth at infinity in
order to obtain more tractable Banach spaces, e.g. Hilbert spaces. We give
first a review of our theory with special emphasis on the specific issues of
the infinite dimensional setting. In a second part we discuss two specific
topics, differential equations and the metric connection. The position of this
line of research with respect to other approaches is briefly discussed.Comment: Submitted for publication in the Proceedings od GSI2013 Aug 28-30
2013 Pari
The Generalized Second Law of Thermodynamics in Cosmology
A classical and quantum mechanical generalized second law of thermodynamics
in cosmology implies constraints on the effective equation of state of the
universe in the form of energy conditions, obeyed by many known cosmological
solutions, and is compatible with entropy bounds which forbid certain
cosmological singularities. In string cosmology the second law provides new
information about the existence of non-singular solutions, and the nature of
the graceful exit transition from dilaton-driven inflation.Comment: 12 pages, no figure
Conformal Predictive Distributions with Kernels
This paper reviews the checkered history of predictive distributions in
statistics and discusses two developments, one from recent literature and the
other new. The first development is bringing predictive distributions into
machine learning, whose early development was so deeply influenced by two
remarkable groups at the Institute of Automation and Remote Control. The second
development is combining predictive distributions with kernel methods, which
were originated by one of those groups, including Emmanuel Braverman.Comment: 20 pages, 3 figures, prepared for the Proceedings of the Braverman
Readings (Boston, 28-30 April 2017
Predictability of evolutionary trajectories in fitness landscapes
Experimental studies on enzyme evolution show that only a small fraction of
all possible mutation trajectories are accessible to evolution. However, these
experiments deal with individual enzymes and explore a tiny part of the fitness
landscape. We report an exhaustive analysis of fitness landscapes constructed
with an off-lattice model of protein folding where fitness is equated with
robustness to misfolding. This model mimics the essential features of the
interactions between amino acids, is consistent with the key paradigms of
protein folding and reproduces the universal distribution of evolutionary rates
among orthologous proteins. We introduce mean path divergence as a quantitative
measure of the degree to which the starting and ending points determine the
path of evolution in fitness landscapes. Global measures of landscape roughness
are good predictors of path divergence in all studied landscapes: the mean path
divergence is greater in smooth landscapes than in rough ones. The
model-derived and experimental landscapes are significantly smoother than
random landscapes and resemble additive landscapes perturbed with moderate
amounts of noise; thus, these landscapes are substantially robust to mutation.
The model landscapes show a deficit of suboptimal peaks even compared with
noisy additive landscapes with similar overall roughness. We suggest that
smoothness and the substantial deficit of peaks in the fitness landscapes of
protein evolution are fundamental consequences of the physics of protein
folding.Comment: 14 pages, 7 figure
Differences in genotype and virulence among four multidrug-resistant <i>Streptococcus pneumoniae</i> isolates belonging to the PMEN1 clone
We report on the comparative genomics and characterization of the virulence phenotypes of four <i>S. pneumoniae</i> strains that belong to the multidrug resistant clone PMEN1 (Spain<sup>23F</sup> ST81). Strains SV35-T23 and SV36-T3 were recovered in 1996 from the nasopharynx of patients at an AIDS hospice in New York. Strain SV36-T3 expressed capsule type 3 which is unusual for this clone and represents the product of an in vivo capsular switch event. A third PMEN1 isolate - PN4595-T23 - was recovered in 1996 from the nasopharynx of a child attending day care in Portugal, and a fourth strain - ATCC700669 - was originally isolated from a patient with pneumococcal disease in Spain in 1984. We compared the genomes among four PMEN1 strains and 47 previously sequenced pneumococcal isolates for gene possession differences and allelic variations within core genes. In contrast to the 47 strains - representing a variety of clonal types - the four PMEN1 strains grouped closely together, demonstrating high genomic conservation within this lineage relative to the rest of the species. In the four PMEN1 strains allelic and gene possession differences were clustered into 18 genomic regions including the capsule, the blp bacteriocins, erythromycin resistance, the MM1-2008 prophage and multiple cell wall anchored proteins. In spite of their genomic similarity, the high resolution chinchilla model was able to detect variations in virulence properties of the PMEN1 strains highlighting how small genic or allelic variation can lead to significant changes in pathogenicity and making this set of strains ideal for the identification of novel virulence determinant
Semiparametric theory and empirical processes in causal inference
In this paper we review important aspects of semiparametric theory and
empirical processes that arise in causal inference problems. We begin with a
brief introduction to the general problem of causal inference, and go on to
discuss estimation and inference for causal effects under semiparametric
models, which allow parts of the data-generating process to be unrestricted if
they are not of particular interest (i.e., nuisance functions). These models
are very useful in causal problems because the outcome process is often complex
and difficult to model, and there may only be information available about the
treatment process (at best). Semiparametric theory gives a framework for
benchmarking efficiency and constructing estimators in such settings. In the
second part of the paper we discuss empirical process theory, which provides
powerful tools for understanding the asymptotic behavior of semiparametric
estimators that depend on flexible nonparametric estimators of nuisance
functions. These tools are crucial for incorporating machine learning and other
modern methods into causal inference analyses. We conclude by examining related
extensions and future directions for work in semiparametric causal inference
Nuclear localization and cytosolic overexpression of LASP-1 correlates with tumor size and nodal-positivity of human breast carcinoma
<p>Abstract</p> <p>Background</p> <p>LIM and SH3 protein 1 (LASP-1), initially identified from human breast cancer, is a specific focal adhesion protein involved in cell proliferation and migration, which was reported to be overexpressed in 8–12 % of human breast cancers and thought to be exclusively located in cytoplasm.</p> <p>Methods</p> <p>In the present work we analyzed the cellular and histological expression pattern of LASP-1 and its involvement in biological behavior of human breast cancer through correlation with standard clinicopathological parameters and expression of c-erbB2 (HER-2/neu), estrogen- (ER) and progesterone-receptors (PR). For this purpose immunohistochemical staining intensity and percentage of stained cells were semi-quantitatively rated to define a LASP-1 immunoreactive score (LASP-1-IRS). LASP-1-IRS was determined in 83 cases of invasive ductal breast carcinomas, 25 ductal carcinomas in situ (DCIS) and 18 fibroadenomas. Cellular LASP-1 distribution and expression pattern was visualized by immunofluorescence and confocal microscopy and assessed through separate Western blots of nuclear and cytosol preparations of BT-20, MCF-7, MDA-MB231, and ZR-75/1 breast cancer cells.</p> <p>Results</p> <p>Statistical analysis revealed that the resulting LASP-1-IRS was significantly higher in invasive carcinomas compared to fibroadenomas (p = 0.0176). Strong cytoplasmatic expression of LASP-1 was detected in 55.4 % of the invasive carcinomas, which correlated significantly with nuclear LASP-1-positivity (p = 0.0014), increased tumor size (p = 0.0159) and rate of nodal-positivity (p = 0.0066). However, levels of LASP-1 expression did not correlate with average age at time point of diagnosis, histological tumor grading, c-erbB2-, ER- or PR-expression.</p> <p>Increased nuclear localization and cytosolic expression of LASP-1 was found in breast cancer with higher tumor stage as well as in rapidly proliferating epidermal basal cells. Confocal microscopy and separate Western blots of cytosolic and nuclear preparations confirmed nuclear localization of LASP-1.</p> <p>Conclusion</p> <p>The current data provide evidence that LASP-1 is not exclusively a cytosolic protein, but is also detectable within the nucleus. Increased expression of LASP-1 in vivo is present in breast carcinomas with higher tumor stage and therefore may be related with worse prognosis concerning patients' overall survival.</p
Alpha2 Macroglobulin-Like Is Essential for Liver Development in Zebrafish
Background: Alpha 2 Macroglobulin family members have been studied extensively with respect to their roles in physiology and human disease including innate immunity and Alzheimer’s disease, but little is known about a possible role in liver development loss-of-function in model systems. Principal Findings: We report the isolation of the zebrafish a2 macroglobulin-like (A2ML) gene and its specific expression in the liver during differentiation. Morpholino-based knock-down of A2ML did not block the initial formation of the liver primordium, but inhibited liver growth and differentiation. Significance: This report on A2ML function in zebrafish development provides the first evidence for a specific role of an A2M family gene in liver formation during early embryogenesis in a vertebrate
Mite species inhabiting commercial bumblebee (Bombus terrestris) nests in Polish greenhouses
Nests of social insects are usually inhabited by various mite species that feed on pollen, other micro-arthropods or are parasitic. Well-known negative effects of worldwide economic importance are caused by mites parasitizing honeybee colonies. Lately, attention has focused on the endoparasitic mite Locustacarus buchneri that has been found in commercial bumblebees. However, little is known of other mites associated with commercial bumblebee nests. Transportation of commercial bumblebee colonies with unwanted residents may introduce foreign mite species to new localities. In this study, we assessed the prevalence and species composition of mites associated with commercial bumblebee nests and determined if the mites are foreign species for Poland and for Europe. The study was conducted on 37 commercial bumblebee nests from two companies (Dutch and Israeli), originating from two greenhouses in southern Poland, and on 20 commercial bumblebee colonies obtained directly from suppliers. The species composition and abundance of mites inhabiting commercial bumblebee nests were determined. Seven mite species from three families were found in nests after greenhouse exploitation. The predominant mite species was Tyrophagus putrescentiae (Acaridae) that was a 100-fold more numerous than representatives of the family Laelapidae (Hypoaspis marginepilosa, H. hyatti, H. bombicolens). Representatives of Parasitidae (Parasitellus fucorum, P. crinitus, P. ignotus) were least numerous. All identified mite species are common throughout Europe, foreign species were not found. Mites were not detected in nests obtained directly from suppliers. We conclude that probably bumblebee nests are invaded by local mite species during greenhouse exploitation
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