Government Expenditure, Foreign Direct Investment and Economic Growth in Nigeria

Government expenditure and Foreign Direct Investment (FDI) are vital macroeconomic variables of any economy as they are strong propellant of economic growth. The need to control and monitoring government spending and the FDI so as to achieve a steady economic growth necessitated this study. The study seeks to determine the impact of government expenditure and FDI on the Nigeria economic growth. A multiple regression analysis was used to test the relationship between government expenditure (capital and recurrent expenditure) and FDI as the explanatory variables on GDP (proxy for economic growth) as the dependent variable. Our result revealed that the explanatory variables: CEXP, REXP and FDI had significant relationship with economic growth. However CEXP did not conform to expectation. Some recommendations such as a thorough and accountable management of capital and recurrent expenditures in Nigeria, adequate planning, an effective macroeconomic framework and conducive economic environment to encourage foreign direct investment is require

Pan-cancer analysis of whole genomes

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation; analyses timings and patterns of tumour evolution; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity; and evaluates a range of more-specialized features of cancer genomes