56,774 research outputs found

    The LIFE Model v1.1

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    Extract: This document draws together feedback, discussion and review of the LIFE Model from a number of sources: 1. The LIFE and LIFE2 Project Teams, and the staff of their institutions 2. Feedback from review by independent economics expert 3. The LIFE Project Conference 4. Early adopters of the Life Model (particularly the Royal Danish Library, State Archives and the State and University Library, Denmark) The result is a revision of the LIFE Model which was first published in 2006 by the LIFE Project . In line with the objectives of the LIFE2 Project, this revision aims to: 1. fix outstanding anomalies or omissions in the Model 2. scope and define the Model and its components more precisely 3. facilitate useful and repeatable mapping and costing of digital lifecycles

    Lifecycle information for E-literature: an introduction to the second phase of the LIFE project

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    Introduction: The first phase of LIFE (Lifecycle Information For E-Literature) made a major contribution to understanding the long-term costs of digital preservation; an essential step in helping institutions plan for the future. The LIFE work models the digital lifecycle and calculates the costs of preserving digital information for future years. Organisations can apply this process in order to understand costs and plan effectively for the preservation of their digital collections The second phase of the LIFE Project, LIFE2, has refined the LIFE Model adding three new exemplar Case Studies to further build upon LIFE1. LIFE2 is an 18-month JISC-funded project between UCL (University College London) and The British Library (BL), supported by the LIBER Access and Preservation Divisions. LIFE1 was completed in April 2006. LIFE2 started in March 2007, and was completed in August 2008. This summary aims to give an overview of the LIFE Project, summarising some of the key outputs. There are four main areas discussed: 1 From LIFE1 to LIFE2 outlines some of the key findings from the first phase of the project as well as summarising the motivation behind this second phase. 2 The LIFE Model describes the current version of the model (version 2) which has been thoroughly updated from the first phase. 3 LIFE2 Case Studies describes the three new Case Studies for LIFE2. It does not include the results from the Case Studies (these are available in the overall LIFE2 Report), but offers some background on each of the studies as well as discussion of why they were chosen. 4 Findings and Conclusions outlines all of the findings and outputs from the entire project

    The LIFE2 final project report

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    Executive summary: The first phase of LIFE (Lifecycle Information For E-Literature) made a major contribution to understanding the long-term costs of digital preservation; an essential step in helping institutions plan for the future. The LIFE work models the digital lifecycle and calculates the costs of preserving digital information for future years. Organisations can apply this process in order to understand costs and plan effectively for the preservation of their digital collections The second phase of the LIFE Project, LIFE2, has refined the LIFE Model adding three new exemplar Case Studies to further build upon LIFE1. LIFE2 is an 18-month JISC-funded project between UCL (University College London) and The British Library (BL), supported by the LIBER Access and Preservation Divisions. LIFE2 began in March 2007, and completed in August 2008. The LIFE approach has been validated by a full independent economic review and has successfully produced an updated lifecycle costing model (LIFE Model v2) and digital preservation costing model (GPM v1.1). The LIFE Model has been tested with three further Case Studies including institutional repositories (SHERPA-LEAP), digital preservation services (SHERPA DP) and a comparison of analogue and digital collections (British Library Newspapers). These Case Studies were useful for scenario building and have fed back into both the LIFE Model and the LIFE Methodology. The experiences of implementing the Case Studies indicated that enhancements made to the LIFE Methodology, Model and associated tools have simplified the costing process. Mapping a specific lifecycle to the LIFE Model isn’t always a straightforward process. The revised and more detailed Model has reduced ambiguity. The costing templates, which were refined throughout the process of developing the Case Studies, ensure clear articulation of both working and cost figures, and facilitate comparative analysis between different lifecycles. The LIFE work has been successfully disseminated throughout the digital preservation and HE communities. Early adopters of the work include the Royal Danish Library, State Archives and the State and University Library, Denmark as well as the LIFE2 Project partners. Furthermore, interest in the LIFE work has not been limited to these sectors, with interest in LIFE expressed by local government, records offices, and private industry. LIFE has also provided input into the LC-JISC Blue Ribbon Task Force on the Economic Sustainability of Digital Preservation. Moving forward our ability to cost the digital preservation lifecycle will require further investment in costing tools and models. Developments in estimative models will be needed to support planning activities, both at a collection management level and at a later preservation planning level once a collection has been acquired. In order to support these developments a greater volume of raw cost data will be required to inform and test new cost models. This volume of data cannot be supported via the Case Study approach, and the LIFE team would suggest that a software tool would provide the volume of costing data necessary to provide a truly accurate predictive model

    Predicting the outer membrane proteome of Pasteurella multocida based on consensus prediction enhanced by results integration and manual confirmation

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    Background Outer membrane proteins (OMPs) of Pasteurella multocida have various functions related to virulence and pathogenesis and represent important targets for vaccine development. Various bioinformatic algorithms can predict outer membrane localization and discriminate OMPs by structure or function. The designation of a confident prediction framework by integrating different predictors followed by consensus prediction, results integration and manual confirmation will improve the prediction of the outer membrane proteome. Results In the present study, we used 10 different predictors classified into three groups (subcellular localization, transmembrane β-barrel protein and lipoprotein predictors) to identify putative OMPs from two available P. multocida genomes: those of avian strain Pm70 and porcine non-toxigenic strain 3480. Predicted proteins in each group were filtered by optimized criteria for consensus prediction: at least two positive predictions for the subcellular localization predictors, three for the transmembrane β-barrel protein predictors and one for the lipoprotein predictors. The consensus predicted proteins were integrated from each group into a single list of proteins. We further incorporated a manual confirmation step including a public database search against PubMed and sequence analyses, e.g. sequence and structural homology, conserved motifs/domains, functional prediction, and protein-protein interactions to enhance the confidence of prediction. As a result, we were able to confidently predict 98 putative OMPs from the avian strain genome and 107 OMPs from the porcine strain genome with 83% overlap between the two genomes. Conclusions The bioinformatic framework developed in this study has increased the number of putative OMPs identified in P. multocida and allowed these OMPs to be identified with a higher degree of confidence. Our approach can be applied to investigate the outer membrane proteomes of other Gram-negative bacteria

    New Cosmological Structures on Medium Angular Scales Detected with the Tenerife Experiments

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    We present observations at 10 and 15 GHz taken with the Tenerife experiments in a band of the sky at Dec.=+35 degrees. These experiments are sensitive to multipoles in the range l=10-30. The sensitivity per beam is 56 and 20 microK for the 10 and the 15 GHz data, respectively. After subtraction of the prediction of known radio-sources, the analysis of the data at 15 GHz at high Galactic latitude shows the presence of a signal with amplitude Delta Trms ~ 32 microK. In the case of a Harrison-Zeldovich spectrum for the primordial fluctuations, a likelihood analysis shows that this signal corresponds to a quadrupole amplitude Q_rms-ps=20.1+7.1-5.4 microK, in agreement with our previous results at Dec.+=40 degrees and with the results of the COBE DMR. There is clear evidence for the presence of individual features in the RA range 190 degrees to 250 degrees with a peak to peak amplitude of ~110 microK. A preliminary comparison between our results and COBE DMR predictions for the Tenerife experiments clearly indicates the presence of individual features common to both. The constancy in amplitude over such a large range in frequency (10-90 GHz) is strongly indicative of an intrinsic cosmological origin for these structures.Comment: ApJ Letters accepted, 13 pages Latex (uses AASTEX) and 4 encapsulated postscript figures

    The Energy-Momentum Tensor in Fulling-Rindler Vacuum

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    The energy density in Fulling-Rindler vacuum, which is known to be negative "everywhere" is shown to be positive and singular on the horizons in such a fashion as to guarantee the positivity of the total energy. The mechanism of compensation is displayed in detail.Comment: 9 pages, ULB-TH-15/9

    The Tenerife Cosmic Microwave Background Maps: Observations and First Analysis

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    The results of the Tenerife Cosmic Microwave Background (CMB) experiments are presented. These observations cover 5000 and 6500 square degrees on the sky at 10 and 15 GHz respectively centred around Dec.~ +35 degrees. The experiments are sensitive to multipoles l=10-30 which corresponds to the Sachs-Wolfe plateau of the CMB power spectra. The sensitivity of the results are ~31 and \~12 microK at 10 and 15 GHz respectively in a beam-size region (5 degrees FWHM). The data at 15 GHz show clear detection of structure at high Galactic latitude; the results at 10 GHz are compatible with these, but at lower significance. A likelihood analysis of the 10 and 15 GHz data at high Galactic latitude, assuming a flat CMB band power spectra gives a signal Delta T_l=30+10-8 microK (68 % C.L.). Including the possible contaminating effect due to the diffuse Galactic component, the CMB signal is Delta T_l=30+15-11 microK. These values are highly stable against the Galactic cut chosen. Assuming a Harrison-Zeldovich spectrum for the primordial fluctuations, the above values imply an expected quadrupole Q_RMS-PS=20+10-7 microK which confirms previous results from these experiments, and which are compatible with the COBE DMR.Comment: 17 pages, 7 figures. Submitted to Ap

    Spin-Excitation Mechanisms in Skyrme-Force Time-Dependent Hartree-Fock

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    We investigate the role of odd-odd (with respect to time inversion) couplings in the Skyrme force on collisions of light nuclei, employing a fully three-dimensional numerical treatment without any symmetry restrictions and with modern Skyrme functionals. We demonstrate the necessity of these couplings to suppress spurious spin excitations owing to the spin-orbit force in free translational motion of a nucleus but show that in a collision situation there is a strong spin excitation even in spin-saturated systems which persists in the departing fragments. The energy loss is considerably increased by the odd-odd terms
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