Assessment of the predictive value of the NTISS scale for neonatal outcomes

The aim of the work is to determine the predictive value of the NTISS scale at the stage of pre-transport preparation in relation to the treatment outcomes of newbornsЦелью работы является определение предиктивной ценности шкалы NTISS на предтранспортном этапе в отношении исходов госпитального этапа лечения новорожденны

The effect of multimodal anesthesia on the cardiovascular system of patients who underwent uterine amputation

The article considers a study conducted to assess the effect of multimodal anesthesia on the cardiovascular system, which included 26 patients who underwent planned surgery in the amount of uterine amputation. The intensity of the pain syndrome was evaluated on a visually analog scale and the data of daily ECG monitoring, during epidural and long-term local anesthesia. It is shown that the performed anesthesia allows to achieve adequate postoperative analgesia in patients with gynecological profile and does not have negative effects on the cardiovascular system.В статье рассмотрено исследование, проведенное с целью оценки влияния мультимодальной анестезии на сердечно-сосудистую систему, включившее 26 пациенток, прооперированных в плановом порядке в объёме ампутация матки. Оценивалась интенсивность болевого синдрома по визуально аналоговой шкале и данные суточного мониторирования ЭКГ, при эпидуральной и длительной локальной анестезии. Представлено, что проводимая анестезия позволяют достичь адекватного послеоперационного обезболивания у пациенток гинекологического профиля и не оказывает негативных эффектов на сердечно сосудистую систему

Comparative analysis of pain levels, preoperative anxiety, depression and laboratory parameters during uterine surgery

Purpose of the study was to determine the factors influencing the development of uncontrolled pain syndrome in patients who underwent uterine surgery.Цель исследования – установить факторы, влияющие на развитие неконтролируемого болевого синдрома у пациенток, перенесших операции на матке

РЕЗУЛЬТАТЫ СОЧЕТАННОЙ ЛУЧЕВОЙ ТЕРАПИИ РАКА ПИЩЕВОДА С ПРИМЕНЕНИЕМ БРАХИТЕРАПИИ ВЫСОКОЙ МОЩНОСТИ

Between 2008 and 2015, 82 patients with inoperable esophageal cancer were treated with radiation therapy. The patients were divided into 3 groups. Group I consisted of 30 patients, who received external beam radiation therapy (EBRT) in combination with brachytherapy. Group II and group III patients (30 and 22 patients, respectively) received EBRT alone. Patients of group II received EBRT at a total dose of 60–70 Gy and patients of group III received EBRT at a total dose of 40–50 Gy. Treatment outcomes were better in patients treated with combination of EBRT and brachytherapy than in patients treated with EBRT alone. There was no significant difference between groups 2 and 3 with regard to their survival rates. Two-year overall survival rates in group I, II and III were 36 %, 12 % and 12 % and the median overall survival time was 15.7; 9.7 and 6.6 months, respectively.Проведено сравнительное исследование с включением 82 пациентов, страдающих раком пищевода, получивших самостоятельный курс лучевой терапии. В первую группу вошли 30 пациентов, получивших сочетанную лучевую терапию с брахитерапией, во 2-ю группу – 30 пациентов, получивших дистанционную лучевую терапию (ДЛТ) до суммарной дозы 60–70 Гр, у 22 пациентов 3-й группы суммарная доза ДЛТ была ограничена 40–50 Гр. Результаты лечения оказались лучше в группе сочетанной лучевой терапии, в то время как значение суммарной дозы ДЛТ не повлияло на показатели выживаемости. Двухлетняя общая выживаемость в сравниваемых группах составила 36, 12 и 12 %, медиана общей выживаемости – 15,7; 9,7 и 6,6 мес соответственно.

Mitochondrial respiratory states and rate

As the knowledge base and importance of mitochondrial physiology to human health expands, the necessity for harmonizing the terminologyconcerning mitochondrial respiratory states and rates has become increasingly apparent. Thechemiosmotic theoryestablishes the mechanism of energy transformationandcoupling in oxidative phosphorylation. Theunifying concept of the protonmotive force providestheframeworkfordeveloping a consistent theoretical foundation ofmitochondrial physiology and bioenergetics.We followguidelines of the International Union of Pure and Applied Chemistry(IUPAC)onterminology inphysical chemistry, extended by considerationsofopen systems and thermodynamicsof irreversible processes.Theconcept-driven constructive terminology incorporates the meaning of each quantity and alignsconcepts and symbols withthe nomenclature of classicalbioenergetics. We endeavour to provide a balanced view ofmitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes.Uniform standards for evaluation of respiratory states and rates will ultimatelycontribute to reproducibility between laboratories and thussupport the development of databases of mitochondrial respiratory function in species, tissues, and cells.Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery