Analyzing the Interaction of Vortex and Gas–Liquid Interface Dynamics in Fuel Spray Nozzles by Means of Lagrangian-Coherent Structures (2D)

Predictions of the primary breakup of fuel in realistic fuel spray nozzles for aero-engine combustors by means of the SPH method are presented. Based on simulations in 2D, novel insights into the fundamental effects of primary breakup are established by analyzing the dynamics of Lagrangian-coherent structures (LCSs). An in-house visualization and data exploration platform is used in order to retrieve fields of the finite-time Lyapunov exponent (FTLE) derived from the SPH predictions aiming at the identification of time resolved LCSs. The main focus of this paper is demonstrating the suitability of FTLE fields to capture and visualize the interaction between the gas and the fuel flow leading to liquid disintegration. Aiming for a convenient illustration at a high spatial resolution, the analysis is presented based on 2D datasets. However, the method and the conclusions can analoguosly be transferred to 3D. The FTLE fields of modified nozzle geometries are compared in order to highlight the influence of the nozzle geometry on primary breakup, which is a novel and unique approach for this industrial application. Modifications of the geometry are proposed which are capable of suppressing the formation of certain LCSs, leading to less fluctuation of the fuel flow emerging from the spray nozzle

Hyper-IgG4 disease: report and characterisation of a new disease

BACKGROUND: We highlight a chronic inflammatory disease we call 'hyper-IgG4 disease', which has many synonyms depending on the organ involved, the country of origin and the year of the report. It is characterized histologically by a lymphoplasmacytic inflammation with IgG4-positive cells and exuberant fibrosis, which leaves dense fibrosis on resolution. A typical example is idiopathic retroperitoneal fibrosis, but the initial report in 2001 was of sclerosing pancreatitis. METHODS: We report an index case with fever and severe systemic disease. We have also reviewed the histology of 11 further patients with idiopathic retroperitoneal fibrosis for evidence of IgG4-expressing plasma cells, and examined a wide range of other inflammatory conditions and fibrotic diseases as organ-specific controls. We have reviewed the published literature for disease associations with idiopathic, systemic fibrosing conditions and the synonyms: pseudotumour, myofibroblastic tumour, plasma cell granuloma, systemic fibrosis, xanthofibrogranulomatosis, and multifocal fibrosclerosis. RESULTS: Histology from all 12 patients showed, to varying degrees, fibrosis, intense inflammatory cell infiltration with lymphocytes, plasma cells, scattered neutrophils, and sometimes eosinophilic aggregates, with venulitis and obliterative arteritis. The majority of lymphocytes were T cells that expressed CD8 and CD4, with scattered B-cell-rich small lymphoid follicles. In all cases, there was a significant increase in IgG4-positive plasma cells compared with controls. In two cases, biopsies before and after steroid treatment were available, and only scattered plasma cells were seen after treatment, none of them expressing IgG4. Review of the literature shows that although pathology commonly appears confined to one organ, patients can have systemic symptoms and fever. In the active period, there is an acute phase response with a high serum concentration of IgG, and during this phase, there is a rapid clinical response to glucocorticoid steroid treatment. CONCLUSION: We believe that hyper-IgG4 disease is an important condition to recognise, as the diagnosis can be readily verified and the outcome with treatment is very good

Nuclear localisation of Aurora-A: its regulation and significance for Aurora-A functions in cancer.

The Aurora-A kinase regulates cell division, by controlling centrosome biology and spindle assembly. Cancer cells often display elevated levels of the kinase, due to amplification of the gene locus, increased transcription or post-translational modifications. Several inhibitors of Aurora-A activity have been developed as anti-cancer agents and are under evaluation in clinical trials. Although the well-known mitotic roles of Aurora-A point at chromosomal instability, a hallmark of cancer, as a major link between Aurora-A overexpression and disease, recent evidence highlights the existence of non-mitotic functions of potential relevance. Here we focus on a nuclear-localised fraction of Aurora-A with oncogenic roles. Interestingly, this pool would identify not only non-mitotic, but also kinase-independent functions of the kinase. We review existing data in the literature and databases, examining potential links between Aurora-A stabilisation and localisation, and discuss them in the perspective of a more effective targeting of Aurora-A in cancer therapy

Analyzing the Interaction of Vortex and Gas–Liquid Interface Dynamics in Fuel Spray Nozzles by Means of Lagrangian-Coherent Structures (2D)

Predictions of the primary breakup of fuel in realistic fuel spray nozzles for aero-engine combustors by means of the SPH method are presented. Based on simulations in 2D, novel insights into the fundamental effects of primary breakup are established by analyzing the dynamics of Lagrangian-coherent structures (LCSs). An in-house visualization and data exploration platform is used in order to retrieve fields of the finite-time Lyapunov exponent (FTLE) derived from the SPH predictions aiming at the identification of time resolved LCSs. The main focus of this paper is demonstrating the suitability of FTLE fields to capture and visualize the interaction between the gas and the fuel flow leading to liquid disintegration. Aiming for a convenient illustration at a high spatial resolution, the analysis is presented based on 2D datasets. However, the method and the conclusions can analoguosly be transferred to 3D. The FTLE fields of modified nozzle geometries are compared in order to highlight the influence of the nozzle geometry on primary breakup, which is a novel and unique approach for this industrial application. Modifications of the geometry are proposed which are capable of suppressing the formation of certain LCSs, leading to less fluctuation of the fuel flow emerging from the spray nozzle