43 research outputs found
Additional file 1: of Attentional and affective consequences of technology supported mindfulness training: a randomised, active control, efficacy trial
Complete Study Data. Complete study data from the baseline and follow-up assessments and the daily experience sampling data. (CSV 32 kb
Enhanced Solid-State NMR Correlation Spectroscopy of Quadrupolar Nuclei Using Dynamic Nuclear Polarization
By means of a true sensitivity enhancement for a solid-state
NMR
spectroscopy (SSNMR) experiment performed under dynamic nuclear polarization
(DNP) conditions, corresponding to 4ā5 orders of magnitude
of time savings compared with a conventional SSNMR experiment, it
is shown that it is possible to record interface-selective <sup>27</sup>Alā<sup>27</sup>Al two-dimensional dipolar correlation spectra
on mesoporous alumina, an advanced material with potential industrial
applications. The low efficiency of cross-polarization and dipolar
recoupling for quadrupolar nuclei is completely negated using this
technique. The important presence of pentacoordinated Al has not only
been observed, but its role in bridging interfacial tetra- and hexacoordinated
Al has been determined. Such structural information, collected at
low temperature (ā¼103 K) and 9.4 T with the use of DNP, would
have been impossible to obtain under standard conditions, even using
a higher magnetic field. However, here it is demonstrated that this
information can be obtained in only 4 h. This work clearly opens a
new avenue for the application of SSNMR to quadrupolar nuclei and
notably the atomic-scale structure determination of catalysis materials
such as mesoporous alumina
Disorder and Sorption Preferences in a Highly Stable Fluoride-Containing Rare-Earth <i>fcu</i>-Type MetalāOrganic Framework
Rare-earth (RE) metalāorganic
frameworks (MOFs) synthesized
in the presence of fluorine-donating modulators or linkers are an
important new subset of functional MOFs. However, the exact nature
of the REaXb core of the molecular building block (MBB) of the MOF, where X is
a Ī¼2Ā orĀ 3-bridging group, remains unclear.
Investigation of one of the archetypal members of this family with
the stable fcu framework topology, Y-fum-fcu-MOF (1), using a combination of experimental
techniques, including high-field (20 T) solid-state nuclear magnetic
resonance spectroscopy, has determined two sources of framework disorder
involving the Ī¼3-X face-capping group of the MBB
and the fumarate (fum) linker. The core of the MBB of 1 is shown to contain a mixture of Ī¼3-Fā and (OH)ā groups with preferential occupation
at the crystallographically different face-capping sites that result
in different internally lined framework tetrahedral cages. The fum
linker is also found to display a disordered arrangement involving
bridgingā or chelatingābridging bis-bidentate modes
over the fum linker positions without influencing the MBB orientation.
This linker disorder will, upon activation, result in the creation
of Y3+ ions with potentially one or two additional uncoordinated
sites possessing differing degrees of Lewis acidity. Crystallographically
determined hostāguest relationships for simple sorbates demonstrate
the favored sorption sites for N2, CO2, and
CS2 molecules that reflect the chemical nature of both
the framework and the sorbate species with the structural partitioning
of the Ī¼3-groups apparent in determining the favored
sorption site of CS2. The two types of disorder found within 1 demonstrate the complexity of fluoride-containing RE-MOFs
and highlight the possibility to tune this and other frameworks to
contain different proportions and segregations of Ī¼3-face-capping groups and degrees of linker disorder for specifically
tailored applications
2011 IEEE International Conference on RFID Photovoltaic Enhanced UHF RFID Tag Antennas for Dual Purpose Energy Harvesting
AbstractāThe most significant barrier to improving passive RFID tag performance for both fixed function ID tags and enhanced RFID tags is the limitation on the amount of power that can be harvested for operation. This paper presents a novel approach for incorporating solar harvesting capability into existing passive RFID tags without increasing the parts count or changing the tag assembly process. Our approach employs the tagās antenna as a dual function element in which the antenna simultaneously harvests RF energy, communicates with the RFID reader, and harvests solar energy for auxiliary power. This is accomplished by using low cost, printable photovoltaics deposited on flexible substrate to form part of the antennaās radiating structure. Several prototype UHF RFID antennas are demonstrated using commercially available thin film, amorphous solar cells. To quantify the improvement in tag performance, Intelās WISP was used as an initial test vehicle. The effective read range of the tag was increased by six times and exceeded the readerās sensitivity limitations. Additionally, the new antenna allowed for sensing and computing operations to take place independent of the RFID reader under typical office lighting conditions
Disorder and Sorption Preferences in a Highly Stable Fluoride-Containing Rare-Earth <i>fcu</i>-Type MetalāOrganic Framework
Rare-earth (RE) metalāorganic
frameworks (MOFs) synthesized
in the presence of fluorine-donating modulators or linkers are an
important new subset of functional MOFs. However, the exact nature
of the REaXb core of the molecular building block (MBB) of the MOF, where X is
a Ī¼2Ā orĀ 3-bridging group, remains unclear.
Investigation of one of the archetypal members of this family with
the stable fcu framework topology, Y-fum-fcu-MOF (1), using a combination of experimental
techniques, including high-field (20 T) solid-state nuclear magnetic
resonance spectroscopy, has determined two sources of framework disorder
involving the Ī¼3-X face-capping group of the MBB
and the fumarate (fum) linker. The core of the MBB of 1 is shown to contain a mixture of Ī¼3-Fā and (OH)ā groups with preferential occupation
at the crystallographically different face-capping sites that result
in different internally lined framework tetrahedral cages. The fum
linker is also found to display a disordered arrangement involving
bridgingā or chelatingābridging bis-bidentate modes
over the fum linker positions without influencing the MBB orientation.
This linker disorder will, upon activation, result in the creation
of Y3+ ions with potentially one or two additional uncoordinated
sites possessing differing degrees of Lewis acidity. Crystallographically
determined hostāguest relationships for simple sorbates demonstrate
the favored sorption sites for N2, CO2, and
CS2 molecules that reflect the chemical nature of both
the framework and the sorbate species with the structural partitioning
of the Ī¼3-groups apparent in determining the favored
sorption site of CS2. The two types of disorder found within 1 demonstrate the complexity of fluoride-containing RE-MOFs
and highlight the possibility to tune this and other frameworks to
contain different proportions and segregations of Ī¼3-face-capping groups and degrees of linker disorder for specifically
tailored applications
Untangling the Condensation Network of Organosiloxanes on Nanoparticles using 2D <sup>29</sup>Siā<sup>29</sup>Si Solid-State NMR Enhanced by Dynamic Nuclear Polarization
Silica (SiO<sub>2</sub>) nanoparticles
(NPs) were functionalized
by silanization to produce a surface covered with organosiloxanes.
Information about the surface coverage and the nature, if any, of
organosiloxane polymerization, whether parallel or perpendicular to
the surface, is highly desired. To this extent, two-dimensional homonuclear <sup>29</sup>Si solid-state NMR could be employed. However, owing to the
sensitivity limitations associated with the low natural abundance
(4.7%) of <sup>29</sup>Si and the difficulty and expense of isotopic
labeling here, this technique would usually be deemed impracticable.
Nevertheless, we show that recent developments in the field of dynamic
nuclear polarization under magic angle spinning (MAS-DNP) could be
used to dramatically increase the sensitivity of the NMR experiments,
resulting in a timesaving factor of ā¼625 compared to conventional
solid-state NMR. This allowed the acquisition of previously infeasible
data. Using both through-space and through-bond 2D <sup>29</sup>Siā<sup>29</sup>Si correlation experiments, it is shown that the required
reaction conditions favor lateral polymerization and domain growth.
Moreover, the natural abundance correlation experiments permitted
the estimation of <sup>2</sup><i>J</i><sup>SiāOāSi</sup>-couplings (13.8 Ā± 1.4 Hz for surface silica) and interatomic
distances (3.04 Ā± 0.08 Ć
for surface silica) since complications
associated with many-spin systems and also sensitivity were avoided.
The work detailed herein not only demonstrates the possibility of
using MAS-DNP to greatly facilitate the acquisition of 2D <sup>29</sup>Siā<sup>29</sup>Si correlation spectra but also shows that
this technique can be used in a routine fashion to characterize surface
grafting networks and gain structural constraints, which can be related
to a systemās chemical and physical properties
Dynamic Nuclear Polarization NMR of LowāĪ³ Nuclei: Structural Insights into Hydrated Yttrium-Doped BaZrO<sub>3</sub>
We demonstrate that solid-state NMR
spectra of challenging nuclei
with a low gyromagnetic ratio such as yttrium-89 can be acquired quickly
with indirect dynamic nuclear polarization (DNP) methods. Proton to <sup>89</sup>Y cross polarization (CP) magic angle spinning (MAS) spectra
of Y<sup>3+</sup> in a frozen aqueous solution were acquired in minutes
using the AMUPol biradical as a polarizing agent. Subsequently, the
detection of the <sup>89</sup>Y and <sup>1</sup>H NMR signals from
technologically important hydrated yttrium-doped zirconate ceramics,
in combination with DFT calculations, allows the local yttrium and
proton environments present in these protonic conductors to be detected
and assigned to different hydrogen-bonded environments
Additional file 1: of Durable regression of Medulloblastoma after regional and intravenous delivery of anti-HER2 chimeric antigen receptor T cells
Figure S1. Characterization of HER2 CAR T cell phenotype. Human T cells were either mock transduced or transduced with HER2 CAR as previously described in Methods. Cells were taken from culture on Day 7 and stained for CD4, CD8, and either a panel of markers of T cell activation (A) or a panel of markers of T cell exhaustion (B). CAR+ T cells were identified by Protein-L staining as previously shown in Fig. 1. Histograms for each population of T cells are shown above, as well as the relevant FMO controls. (PPTX 389 kb
Additional file 3: of Durable regression of Medulloblastoma after regional and intravenous delivery of anti-HER2 chimeric antigen receptor T cells
Figure S3. Linear regression data used for calculating statistics from Figs. 2, 3, 4, and 5. Data is presented as spider plots, with each line representing data from an individual mouse, and linear regression lines and equations overlaid. Fig.ĆĀ 2b. Fig.ĆĀ 3b. Fig.ĆĀ 4b. Fig.ĆĀ 5b. (PPTX 274 kb
Additional file 1: Figure S1. of Identifying biomarkers of dementia prevalent among amnestic mild cognitively impaired ethnic female patients
Plasma biomarkers that did not significantly change among ethnicities and disease status. Graphs represent six out of 12 biomarkers that were not significantly changed among ethnic groups with aMCI disease status compared with age-matched controls (NC). Statistical analyses were performed in a two by three factorial design with post-hoc analyses using IBM SPSS Statistics 22. An outlier test via IBM SPSS Statistics 22 was performed on each data set and outliers were removed. (TIFF 1521 kb